Early Intervention in Ulcerative Colitis: Ready for Prime Time?
Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn’s disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately...
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| Veröffentlicht in: | Journal of clinical medicine 2020-08, Vol.9 (8), p.2646 |
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| creator | Solitano, Virginia D’Amico, Ferdinando Zacharopoulou, Eirini Peyrin-Biroulet, Laurent Danese, Silvio |
| description | Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn’s disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately controlled by current management, leading to poor long-term prognosis. Data from both randomized controlled trials and real-world studies support early intervention in CD in order to prevent disease progression and irreversible bowel damage. Similarly, an early disease intervention during the so-called “window of opportunity” could lead to better outcomes in UC. Here, we summarize the literature evidence on early intervention in patients with UC, highlighting strengths and limitations of this approach. |
| doi_str_mv | 10.3390/jcm9082646 |
| format | Article |
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The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately controlled by current management, leading to poor long-term prognosis. Data from both randomized controlled trials and real-world studies support early intervention in CD in order to prevent disease progression and irreversible bowel damage. Similarly, an early disease intervention during the so-called “window of opportunity” could lead to better outcomes in UC. Here, we summarize the literature evidence on early intervention in patients with UC, highlighting strengths and limitations of this approach.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9082646</identifier><identifier>PMID: 32823997</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Biological products ; Clinical medicine ; Clinical trials ; Crohn's disease ; Early intervention ; Fecal incontinence ; Inflammation ; Inflammatory bowel disease ; Patients ; Remission (Medicine) ; Review ; Steroids ; Surgery ; Systematic review ; Tumor necrosis factor-TNF</subject><ispartof>Journal of clinical medicine, 2020-08, Vol.9 (8), p.2646</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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D’Amico, Ferdinando ; Zacharopoulou, Eirini ; Peyrin-Biroulet, Laurent ; Danese, Silvio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-557cbfcc52fe72b43acd43e795e55a5dd3d8fc0f94b783668048305fdf75e41b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biological products</topic><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Crohn's disease</topic><topic>Early intervention</topic><topic>Fecal incontinence</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Patients</topic><topic>Remission (Medicine)</topic><topic>Review</topic><topic>Steroids</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solitano, Virginia</creatorcontrib><creatorcontrib>D’Amico, Ferdinando</creatorcontrib><creatorcontrib>Zacharopoulou, Eirini</creatorcontrib><creatorcontrib>Peyrin-Biroulet, Laurent</creatorcontrib><creatorcontrib>Danese, Silvio</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solitano, Virginia</au><au>D’Amico, Ferdinando</au><au>Zacharopoulou, Eirini</au><au>Peyrin-Biroulet, Laurent</au><au>Danese, Silvio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Intervention in Ulcerative Colitis: Ready for Prime Time?</atitle><jtitle>Journal of clinical medicine</jtitle><date>2020-08-14</date><risdate>2020</risdate><volume>9</volume><issue>8</issue><spage>2646</spage><pages>2646-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Growing evidence shows that ulcerative colitis (UC) is a progressive disease similar to Crohn’s disease (CD). The UC-related burden is often underestimated by physicians and a standard step-up therapeutic approach is preferred. However, in many patients with UC the disease activity is not adequately controlled by current management, leading to poor long-term prognosis. Data from both randomized controlled trials and real-world studies support early intervention in CD in order to prevent disease progression and irreversible bowel damage. Similarly, an early disease intervention during the so-called “window of opportunity” could lead to better outcomes in UC. Here, we summarize the literature evidence on early intervention in patients with UC, highlighting strengths and limitations of this approach.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32823997</pmid><doi>10.3390/jcm9082646</doi><orcidid>https://orcid.org/0000-0002-2935-6778</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biological products Clinical medicine Clinical trials Crohn's disease Early intervention Fecal incontinence Inflammation Inflammatory bowel disease Patients Remission (Medicine) Review Steroids Surgery Systematic review Tumor necrosis factor-TNF |
| title | Early Intervention in Ulcerative Colitis: Ready for Prime Time? |
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