Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality
Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmi...
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| Veröffentlicht in: | Journal of clinical medicine 2020-08, Vol.9 (8), p.2478 |
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| creator | Boucret, Lisa Bouet, Pierre-Emmanuel Riou, Jérémie Legendre, Guillaume Delbos, Léa Hachem, Hady El Descamps, Philippe Reynier, Pascal May-Panloup, Pascale |
| description | Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality. |
| doi_str_mv | 10.3390/jcm9082478 |
| format | Article |
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This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9082478</identifier><identifier>PMID: 32752267</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Classification ; Clinical medicine ; Embryos ; Endometriosis ; In vitro fertilization ; Infertility ; Life Sciences ; Morphology ; Ovaries ; Pain ; Patients ; Pregnancy ; Quality of life ; Reproductive health ; Reproductive technologies ; Sperm ; Surgery ; Ultrasonic imaging ; Vagina ; Womens health</subject><ispartof>Journal of clinical medicine, 2020-08, Vol.9 (8), p.2478</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e29940b72872c20a9380eaeb746c5ecb6e01b35c8833dad2eb0559a0e9ab4eda3</citedby><cites>FETCH-LOGICAL-c417t-e29940b72872c20a9380eaeb746c5ecb6e01b35c8833dad2eb0559a0e9ab4eda3</cites><orcidid>0000-0002-7056-9257 ; 0000-0003-0802-4608 ; 0000-0001-7609-7265 ; 0000-0002-9788-8581</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464781/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464781/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53768,53770</link.rule.ids><backlink>$$Uhttps://univ-angers.hal.science/hal-02953557$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boucret, Lisa</creatorcontrib><creatorcontrib>Bouet, Pierre-Emmanuel</creatorcontrib><creatorcontrib>Riou, Jérémie</creatorcontrib><creatorcontrib>Legendre, Guillaume</creatorcontrib><creatorcontrib>Delbos, Léa</creatorcontrib><creatorcontrib>Hachem, Hady El</creatorcontrib><creatorcontrib>Descamps, Philippe</creatorcontrib><creatorcontrib>Reynier, Pascal</creatorcontrib><creatorcontrib>May-Panloup, Pascale</creatorcontrib><title>Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality</title><title>Journal of clinical medicine</title><description>Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.</description><subject>Classification</subject><subject>Clinical medicine</subject><subject>Embryos</subject><subject>Endometriosis</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Life Sciences</subject><subject>Morphology</subject><subject>Ovaries</subject><subject>Pain</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Quality of life</subject><subject>Reproductive health</subject><subject>Reproductive technologies</subject><subject>Sperm</subject><subject>Surgery</subject><subject>Ultrasonic imaging</subject><subject>Vagina</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkdtu1DAQhiMEolXpDU9giRtAWnB8iO0bpLJsD1JUBCrcWrYz23iVxK0Pi_btm2UrDvXFeOT5_n-smap6XeMPlCr8ceNGhSVhQj6rjgkWYoGppM__yY-q05Q2eD5SMlKLl9URJYIT0ojjqqymLoyQow_JJ9SGXxATyj2gZRnLYLLfAmr34bOPuUffTYaE_ISufp4ju0NfwEUwyU-3v0XXZbQQUVij1WjjLiRkS0bXIaObHnxE34oZfN69ql6szZDg9PE-qX6cr26Wl4v268XV8qxdOFaLvACiFMNWECmII9goKjEYsII1joOzDeDaUu6kpLQzHQGLOVcGgzKWQWfoSfXp4HtX7AidgylHM-i76EcTdzoYr_-vTL7Xt2Gr5w7zROvZ4N3BoH8iuzxr9f4NE8Up52K7Z98-NovhvkDKevTJwTCYCUJJmjCKGyYxVzP65gm6CSVO8yg0aViNeUNqPlPvD5SLIaUI6z8_qLHeL1__XT59AMj2oDY</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Boucret, Lisa</creator><creator>Bouet, Pierre-Emmanuel</creator><creator>Riou, Jérémie</creator><creator>Legendre, Guillaume</creator><creator>Delbos, Léa</creator><creator>Hachem, Hady El</creator><creator>Descamps, Philippe</creator><creator>Reynier, Pascal</creator><creator>May-Panloup, Pascale</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7056-9257</orcidid><orcidid>https://orcid.org/0000-0003-0802-4608</orcidid><orcidid>https://orcid.org/0000-0001-7609-7265</orcidid><orcidid>https://orcid.org/0000-0002-9788-8581</orcidid></search><sort><creationdate>20200801</creationdate><title>Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality</title><author>Boucret, Lisa ; Bouet, Pierre-Emmanuel ; Riou, Jérémie ; Legendre, Guillaume ; Delbos, Léa ; Hachem, Hady El ; Descamps, Philippe ; Reynier, Pascal ; May-Panloup, Pascale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e29940b72872c20a9380eaeb746c5ecb6e01b35c8833dad2eb0559a0e9ab4eda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Classification</topic><topic>Clinical medicine</topic><topic>Embryos</topic><topic>Endometriosis</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Life Sciences</topic><topic>Morphology</topic><topic>Ovaries</topic><topic>Pain</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Quality of life</topic><topic>Reproductive health</topic><topic>Reproductive technologies</topic><topic>Sperm</topic><topic>Surgery</topic><topic>Ultrasonic imaging</topic><topic>Vagina</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boucret, Lisa</creatorcontrib><creatorcontrib>Bouet, Pierre-Emmanuel</creatorcontrib><creatorcontrib>Riou, Jérémie</creatorcontrib><creatorcontrib>Legendre, Guillaume</creatorcontrib><creatorcontrib>Delbos, Léa</creatorcontrib><creatorcontrib>Hachem, Hady El</creatorcontrib><creatorcontrib>Descamps, Philippe</creatorcontrib><creatorcontrib>Reynier, Pascal</creatorcontrib><creatorcontrib>May-Panloup, Pascale</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boucret, Lisa</au><au>Bouet, Pierre-Emmanuel</au><au>Riou, Jérémie</au><au>Legendre, Guillaume</au><au>Delbos, Léa</au><au>Hachem, Hady El</au><au>Descamps, Philippe</au><au>Reynier, Pascal</au><au>May-Panloup, Pascale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality</atitle><jtitle>Journal of clinical medicine</jtitle><date>2020-08-01</date><risdate>2020</risdate><volume>9</volume><issue>8</issue><spage>2478</spage><pages>2478-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32752267</pmid><doi>10.3390/jcm9082478</doi><orcidid>https://orcid.org/0000-0002-7056-9257</orcidid><orcidid>https://orcid.org/0000-0003-0802-4608</orcidid><orcidid>https://orcid.org/0000-0001-7609-7265</orcidid><orcidid>https://orcid.org/0000-0002-9788-8581</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Classification Clinical medicine Embryos Endometriosis In vitro fertilization Infertility Life Sciences Morphology Ovaries Pain Patients Pregnancy Quality of life Reproductive health Reproductive technologies Sperm Surgery Ultrasonic imaging Vagina Womens health |
| title | Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality |
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