Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles

Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients. They have differing prognoses and are currently distinguished using histological criteria, such as invasion of deeper tissue structures, necrosis and lymphovascular or perineural invas...

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Veröffentlicht in:	Modern pathology 2018-03, Vol.31 (3), p.418-428
Hauptverfasser:	Griewank, Klaus G, Wiesner, Thomas, Murali, Rajmohan, Pischler, Carina, Müller, Hansgeorg, Koelsche, Christian, Möller, Inga, Franklin, Cindy, Cosgarea, Ioana, Sucker, Antje, Schadendorf, Dirk, Schaller, Jörg, Horn, Susanne, Brenn, Thomas, Mentzel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 45/77 692/308/2056 692/308/575 Aged Aged, 80 and over Cadherins - genetics Comparative Genomic Hybridization Copy number Cyclin-Dependent Kinase Inhibitor p16 - genetics Deoxyribonucleic acid DNA DNA Copy Number Variations DNA sequencing Female Geriatrics Humans Hybridization Laboratory Medicine Male Medicine Medicine & Public Health Middle Aged Mutation original-article p53 Protein Pathology Prognosis Promoter Regions, Genetic Receptor, Notch1 - genetics Receptor, Notch2 - genetics Sarcoma Sarcoma - genetics Skin Skin Neoplasms - genetics Telomerase - genetics Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumors
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