Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence
Background The “watch-and-wait” approach is a common treatment option amongst patients with locally advanced rectal cancer (LARC). However, the diagnostic sensitivity of clinical modalities, such as colonoscopy and magnetic resonance imaging to determine pathological response, is not high. We analys...
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| Veröffentlicht in: | British journal of cancer 2020-09, Vol.123 (5), p.803-810 |
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| creator | Murahashi, Satoshi Akiyoshi, Takashi Sano, Takeshi Fukunaga, Yosuke Noda, Tetsuo Ueno, Masashi Zembutsu, Hitoshi |
| description | Background
The “watch-and-wait” approach is a common treatment option amongst patients with locally advanced rectal cancer (LARC). However, the diagnostic sensitivity of clinical modalities, such as colonoscopy and magnetic resonance imaging to determine pathological response, is not high. We analysed the clinical utility of circulating tumour DNA (ctDNA) of patients with LARC to predict response to preoperative therapy and postoperative recurrence.
Methods
A serial ctDNA analysis of 222 plasma samples from 85 patients with LARC was performed using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with over 240 hotspots.
Results
ctDNA was detected in 57.6% and 22.3% of samples at baseline and after preoperative treatment, respectively, which was significantly different (
P
= 0.0003). Change in ctDNA was an independent predictor of complete response to preoperative therapy (
P
= 0.0276). In addition, postoperative ctDNA and carcinoembryonic antigen (CEA) were independent prognostic markers for risk of recurrence after surgery (ctDNA,
P
= 0.0127 and CEA,
P
= 0.0105), with a combined analysis having cumulative effects on recurrence-free survival (
P
= 1.0 × 10
–16
).
Conclusions
Serial ctDNA analysis may offer clinically useful predictive and prognostic markers for response to preoperative therapy and postoperative recurrence in patients with LARC. |
| doi_str_mv | 10.1038/s41416-020-0941-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7462982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2475029474</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-f0fb7018d5fa3db30c63562c703cf73d16b873bb12eb96085110275f58a9fc2e3</originalsourceid><addsrcrecordid>eNp9kk2PFCEQhonRuOvqD_BiSLx4aeWzAQ8mm_Uz2ehBPROahhk2TNMCPWZ-lP9ROrPuqomeoKreegoqLwCPMXqOEZUvCsMM9x0iqEOK4Y7dAaeYU9JhScRdcIoQEq1C0Al4UMpVCxWS4j44oYT3nFN1Cn58djmYCG3IdommhmkD67JLS4avP55DM5l4KKFAnzKMyZoYD9CMezNZN8LsbF171yjDmp2pLfs91C2cs0uzyw24d7Bu220-vFyzY7A1pAkmD2dTtymmTWjYxipzmoprI0c4p1Jv29uYJWfXhjwE97yJxT26Ps_A17dvvly87y4_vftwcX7ZWaZk7Tzyg0BYjtwbOg4U2Z7ynliBqPWCjrgfpKDDgIkbVI8kxxgRwT2XRnlLHD0Dr47ceRl2brRuqtlEPeewM_mgkwn6z8oUtnqT9lqwnihJGuDZNSCnb4srVe9CsS5GM7m0FE0Y5pIy1dMmffqX9Kptv-19VQmOiGKC_V9FFcaES9xU-KiyOZWSnb95MkZ6tYw-WkY3y-jVMnolP_n9rzcdvzzSBOQoKK00bVy-Hf1v6k-WItC7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2439112581</pqid></control><display><type>article</type><title>Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Murahashi, Satoshi ; Akiyoshi, Takashi ; Sano, Takeshi ; Fukunaga, Yosuke ; Noda, Tetsuo ; Ueno, Masashi ; Zembutsu, Hitoshi</creator><creatorcontrib>Murahashi, Satoshi ; Akiyoshi, Takashi ; Sano, Takeshi ; Fukunaga, Yosuke ; Noda, Tetsuo ; Ueno, Masashi ; Zembutsu, Hitoshi</creatorcontrib><description>Background
The “watch-and-wait” approach is a common treatment option amongst patients with locally advanced rectal cancer (LARC). However, the diagnostic sensitivity of clinical modalities, such as colonoscopy and magnetic resonance imaging to determine pathological response, is not high. We analysed the clinical utility of circulating tumour DNA (ctDNA) of patients with LARC to predict response to preoperative therapy and postoperative recurrence.
Methods
A serial ctDNA analysis of 222 plasma samples from 85 patients with LARC was performed using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with over 240 hotspots.
Results
ctDNA was detected in 57.6% and 22.3% of samples at baseline and after preoperative treatment, respectively, which was significantly different (
P
= 0.0003). Change in ctDNA was an independent predictor of complete response to preoperative therapy (
P
= 0.0276). In addition, postoperative ctDNA and carcinoembryonic antigen (CEA) were independent prognostic markers for risk of recurrence after surgery (ctDNA,
P
= 0.0127 and CEA,
P
= 0.0105), with a combined analysis having cumulative effects on recurrence-free survival (
P
= 1.0 × 10
–16
).
Conclusions
Serial ctDNA analysis may offer clinically useful predictive and prognostic markers for response to preoperative therapy and postoperative recurrence in patients with LARC.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-020-0941-4</identifier><identifier>PMID: 32565539</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1504/1885/1777 ; 631/67/1857 ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoembryonic antigen ; Circulating Tumor DNA - blood ; Circulating Tumor DNA - genetics ; Colon ; Colorectal cancer ; Deoxyribonucleic acid ; DNA ; DNA sequencing ; Drug Resistance ; Epidemiology ; Female ; Humans ; Magnetic resonance imaging ; Male ; Middle Aged ; Molecular Medicine ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local - blood ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Oncology ; Patients ; Prognosis ; Rectal Neoplasms - blood ; Rectal Neoplasms - genetics ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Rectum ; Surgery ; Tumors</subject><ispartof>British journal of cancer, 2020-09, Vol.123 (5), p.803-810</ispartof><rights>The Author(s), under exclusive licence to Cancer Research UK 2020</rights><rights>The Author(s), under exclusive licence to Cancer Research UK 2020.</rights><rights>The Author(s), under exclusive licence to Cancer Research UK 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-f0fb7018d5fa3db30c63562c703cf73d16b873bb12eb96085110275f58a9fc2e3</citedby><cites>FETCH-LOGICAL-c498t-f0fb7018d5fa3db30c63562c703cf73d16b873bb12eb96085110275f58a9fc2e3</cites><orcidid>0000-0002-6397-0907 ; 0000-0002-1674-1968 ; 0000-0002-2321-1412 ; 0000-0001-9397-4071</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462982/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462982/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32565539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murahashi, Satoshi</creatorcontrib><creatorcontrib>Akiyoshi, Takashi</creatorcontrib><creatorcontrib>Sano, Takeshi</creatorcontrib><creatorcontrib>Fukunaga, Yosuke</creatorcontrib><creatorcontrib>Noda, Tetsuo</creatorcontrib><creatorcontrib>Ueno, Masashi</creatorcontrib><creatorcontrib>Zembutsu, Hitoshi</creatorcontrib><title>Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background
The “watch-and-wait” approach is a common treatment option amongst patients with locally advanced rectal cancer (LARC). However, the diagnostic sensitivity of clinical modalities, such as colonoscopy and magnetic resonance imaging to determine pathological response, is not high. We analysed the clinical utility of circulating tumour DNA (ctDNA) of patients with LARC to predict response to preoperative therapy and postoperative recurrence.
Methods
A serial ctDNA analysis of 222 plasma samples from 85 patients with LARC was performed using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with over 240 hotspots.
Results
ctDNA was detected in 57.6% and 22.3% of samples at baseline and after preoperative treatment, respectively, which was significantly different (
P
= 0.0003). Change in ctDNA was an independent predictor of complete response to preoperative therapy (
P
= 0.0276). In addition, postoperative ctDNA and carcinoembryonic antigen (CEA) were independent prognostic markers for risk of recurrence after surgery (ctDNA,
P
= 0.0127 and CEA,
P
= 0.0105), with a combined analysis having cumulative effects on recurrence-free survival (
P
= 1.0 × 10
–16
).
Conclusions
Serial ctDNA analysis may offer clinically useful predictive and prognostic markers for response to preoperative therapy and postoperative recurrence in patients with LARC.</description><subject>631/67/1504/1885/1777</subject><subject>631/67/1857</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoembryonic antigen</subject><subject>Circulating Tumor DNA - blood</subject><subject>Circulating Tumor DNA - genetics</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Rectal Neoplasms - blood</subject><subject>Rectal Neoplasms - genetics</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Rectum</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk2PFCEQhonRuOvqD_BiSLx4aeWzAQ8mm_Uz2ehBPROahhk2TNMCPWZ-lP9ROrPuqomeoKreegoqLwCPMXqOEZUvCsMM9x0iqEOK4Y7dAaeYU9JhScRdcIoQEq1C0Al4UMpVCxWS4j44oYT3nFN1Cn58djmYCG3IdommhmkD67JLS4avP55DM5l4KKFAnzKMyZoYD9CMezNZN8LsbF171yjDmp2pLfs91C2cs0uzyw24d7Bu220-vFyzY7A1pAkmD2dTtymmTWjYxipzmoprI0c4p1Jv29uYJWfXhjwE97yJxT26Ps_A17dvvly87y4_vftwcX7ZWaZk7Tzyg0BYjtwbOg4U2Z7ynliBqPWCjrgfpKDDgIkbVI8kxxgRwT2XRnlLHD0Dr47ceRl2brRuqtlEPeewM_mgkwn6z8oUtnqT9lqwnihJGuDZNSCnb4srVe9CsS5GM7m0FE0Y5pIy1dMmffqX9Kptv-19VQmOiGKC_V9FFcaES9xU-KiyOZWSnb95MkZ6tYw-WkY3y-jVMnolP_n9rzcdvzzSBOQoKK00bVy-Hf1v6k-WItC7</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Murahashi, Satoshi</creator><creator>Akiyoshi, Takashi</creator><creator>Sano, Takeshi</creator><creator>Fukunaga, Yosuke</creator><creator>Noda, Tetsuo</creator><creator>Ueno, Masashi</creator><creator>Zembutsu, Hitoshi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6397-0907</orcidid><orcidid>https://orcid.org/0000-0002-1674-1968</orcidid><orcidid>https://orcid.org/0000-0002-2321-1412</orcidid><orcidid>https://orcid.org/0000-0001-9397-4071</orcidid></search><sort><creationdate>20200901</creationdate><title>Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence</title><author>Murahashi, Satoshi ; Akiyoshi, Takashi ; Sano, Takeshi ; Fukunaga, Yosuke ; Noda, Tetsuo ; Ueno, Masashi ; Zembutsu, Hitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-f0fb7018d5fa3db30c63562c703cf73d16b873bb12eb96085110275f58a9fc2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/67/1504/1885/1777</topic><topic>631/67/1857</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoembryonic antigen</topic><topic>Circulating Tumor DNA - blood</topic><topic>Circulating Tumor DNA - genetics</topic><topic>Colon</topic><topic>Colorectal cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA sequencing</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Recurrence, Local - blood</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Rectal Neoplasms - blood</topic><topic>Rectal Neoplasms - genetics</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Rectum</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murahashi, Satoshi</creatorcontrib><creatorcontrib>Akiyoshi, Takashi</creatorcontrib><creatorcontrib>Sano, Takeshi</creatorcontrib><creatorcontrib>Fukunaga, Yosuke</creatorcontrib><creatorcontrib>Noda, Tetsuo</creatorcontrib><creatorcontrib>Ueno, Masashi</creatorcontrib><creatorcontrib>Zembutsu, Hitoshi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murahashi, Satoshi</au><au>Akiyoshi, Takashi</au><au>Sano, Takeshi</au><au>Fukunaga, Yosuke</au><au>Noda, Tetsuo</au><au>Ueno, Masashi</au><au>Zembutsu, Hitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>123</volume><issue>5</issue><spage>803</spage><epage>810</epage><pages>803-810</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Background
The “watch-and-wait” approach is a common treatment option amongst patients with locally advanced rectal cancer (LARC). However, the diagnostic sensitivity of clinical modalities, such as colonoscopy and magnetic resonance imaging to determine pathological response, is not high. We analysed the clinical utility of circulating tumour DNA (ctDNA) of patients with LARC to predict response to preoperative therapy and postoperative recurrence.
Methods
A serial ctDNA analysis of 222 plasma samples from 85 patients with LARC was performed using amplicon-based deep sequencing on a cell-free DNA panel covering 14 genes with over 240 hotspots.
Results
ctDNA was detected in 57.6% and 22.3% of samples at baseline and after preoperative treatment, respectively, which was significantly different (
P
= 0.0003). Change in ctDNA was an independent predictor of complete response to preoperative therapy (
P
= 0.0276). In addition, postoperative ctDNA and carcinoembryonic antigen (CEA) were independent prognostic markers for risk of recurrence after surgery (ctDNA,
P
= 0.0127 and CEA,
P
= 0.0105), with a combined analysis having cumulative effects on recurrence-free survival (
P
= 1.0 × 10
–16
).
Conclusions
Serial ctDNA analysis may offer clinically useful predictive and prognostic markers for response to preoperative therapy and postoperative recurrence in patients with LARC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32565539</pmid><doi>10.1038/s41416-020-0941-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6397-0907</orcidid><orcidid>https://orcid.org/0000-0002-1674-1968</orcidid><orcidid>https://orcid.org/0000-0002-2321-1412</orcidid><orcidid>https://orcid.org/0000-0001-9397-4071</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2020-09, Vol.123 (5), p.803-810 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 631/67/1504/1885/1777 631/67/1857 Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Research Carcinoembryonic antigen Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Colon Colorectal cancer Deoxyribonucleic acid DNA DNA sequencing Drug Resistance Epidemiology Female Humans Magnetic resonance imaging Male Middle Aged Molecular Medicine Neoadjuvant Therapy Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Staging Oncology Patients Prognosis Rectal Neoplasms - blood Rectal Neoplasms - genetics Rectal Neoplasms - pathology Rectal Neoplasms - therapy Rectum Surgery Tumors |
| title | Serial circulating tumour DNA analysis for locally advanced rectal cancer treated with preoperative therapy: prediction of pathological response and postoperative recurrence |
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