Greener synthesis of Rod Shaped Zinc Oxide Nanoparticles using Lilium ledebourii tuber and evaluation of their Leishmanicidal activity
Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. Nanoparticles have been used as an antimicrobial agents to inhibit microbial growth. In view of the strong antimicrobial activity of nanoparticles, t...
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| Veröffentlicht in: | Iranian journal of biotechnology 2020-01, Vol.18 (1), p.e2196-e2196 |
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| creator | Khatami, Mehrdad Khatami, Sanaz Mosazade, Farideh Raisi, Mahammadali Haghighat, Mojtaba Sabaghan, Mohamad Yaghoubi, Sajad Sarani, Mina Bamorovat, Mehdi Malekian, Leila Naroi, Afsoon S Varma, Rajender |
| description | Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. Nanoparticles have been used as an antimicrobial agents to inhibit microbial growth.
In view of the strong antimicrobial activity of nanoparticles, the biogenic synthesis and leishmanicidal activity of rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract.
The ensuing nanoparticles are characterized by UV-visible spectroscopy, X-ray diffraction and transmission electron microscopy and their leishmanicidal activity evaluated against the Leishmania major (L. major) by MTT assay.
The R-ZnO nanoparticles displayed excellent leishmanicidal activity against the L. major as they significantly inhibited the amastigotes. The IC
values of R-ZnO nanoparticles being ~ 0.001 mg.mL
. R-ZnO nanoparticles can inhibit L. major growth in a dose-dependent manner under in vitro conditions.
A simple, low-cost feasible and eco-friendly procedure was developed for biosynthesis of R-ZnO nanoparticles using natural bioresource that can inhibit human parasite cells growth in a dose-dependent manner under in vitro conditions. |
| doi_str_mv | 10.30498/IJB.2020.119481.2196 |
| format | Article |
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In view of the strong antimicrobial activity of nanoparticles, the biogenic synthesis and leishmanicidal activity of rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract.
The ensuing nanoparticles are characterized by UV-visible spectroscopy, X-ray diffraction and transmission electron microscopy and their leishmanicidal activity evaluated against the Leishmania major (L. major) by MTT assay.
The R-ZnO nanoparticles displayed excellent leishmanicidal activity against the L. major as they significantly inhibited the amastigotes. The IC
values of R-ZnO nanoparticles being ~ 0.001 mg.mL
. R-ZnO nanoparticles can inhibit L. major growth in a dose-dependent manner under in vitro conditions.
A simple, low-cost feasible and eco-friendly procedure was developed for biosynthesis of R-ZnO nanoparticles using natural bioresource that can inhibit human parasite cells growth in a dose-dependent manner under in vitro conditions.</description><identifier>ISSN: 1728-3043</identifier><identifier>EISSN: 2322-2921</identifier><identifier>DOI: 10.30498/IJB.2020.119481.2196</identifier><identifier>PMID: 32884950</identifier><language>eng</language><publisher>Iran: National Institute of Genetic Engineering and Biotechnology</publisher><ispartof>Iranian journal of biotechnology, 2020-01, Vol.18 (1), p.e2196-e2196</ispartof><rights>Copyright: © 2019 The Author(s); Published by Iranian Journal of Biotechnology.</rights><rights>Copyright: © 2019 The Author(s); Published by Iranian Journal of Biotechnology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461714/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461714/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32884950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khatami, Mehrdad</creatorcontrib><creatorcontrib>Khatami, Sanaz</creatorcontrib><creatorcontrib>Mosazade, Farideh</creatorcontrib><creatorcontrib>Raisi, Mahammadali</creatorcontrib><creatorcontrib>Haghighat, Mojtaba</creatorcontrib><creatorcontrib>Sabaghan, Mohamad</creatorcontrib><creatorcontrib>Yaghoubi, Sajad</creatorcontrib><creatorcontrib>Sarani, Mina</creatorcontrib><creatorcontrib>Bamorovat, Mehdi</creatorcontrib><creatorcontrib>Malekian, Leila</creatorcontrib><creatorcontrib>Naroi, Afsoon</creatorcontrib><creatorcontrib>S Varma, Rajender</creatorcontrib><title>Greener synthesis of Rod Shaped Zinc Oxide Nanoparticles using Lilium ledebourii tuber and evaluation of their Leishmanicidal activity</title><title>Iranian journal of biotechnology</title><addtitle>Iran J Biotechnol</addtitle><description>Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. Nanoparticles have been used as an antimicrobial agents to inhibit microbial growth.
In view of the strong antimicrobial activity of nanoparticles, the biogenic synthesis and leishmanicidal activity of rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract.
The ensuing nanoparticles are characterized by UV-visible spectroscopy, X-ray diffraction and transmission electron microscopy and their leishmanicidal activity evaluated against the Leishmania major (L. major) by MTT assay.
The R-ZnO nanoparticles displayed excellent leishmanicidal activity against the L. major as they significantly inhibited the amastigotes. The IC
values of R-ZnO nanoparticles being ~ 0.001 mg.mL
. R-ZnO nanoparticles can inhibit L. major growth in a dose-dependent manner under in vitro conditions.
A simple, low-cost feasible and eco-friendly procedure was developed for biosynthesis of R-ZnO nanoparticles using natural bioresource that can inhibit human parasite cells growth in a dose-dependent manner under in vitro conditions.</description><issn>1728-3043</issn><issn>2322-2921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpV0E1O3EAQBeAWCoIJ4QigvoCd_rPdvUEiKCGgEUgJ2bCx-qeMK7LbltseZS6Qc2MUiJJVLd5736IIOeMsl0wZ_fHm9lMumGA550ZpngtuygOyEVKITBjB35ENr4TO1rY8Ju9T-slYURomj8ixFForU7AN-X09AUSYaNrHuYWEiQ4N_TYE-r21IwT6iNHT-18YgN7ZOIx2mtF3kOiSMD7RLXa49LSDAG5YJkQ6L27lbAwUdrZb7IxDfDFXHSe6BUxtbyN6DLaj1s-4w3n_gRw2tktw-npPyI8vnx-uvmbb--ubq8ttNnLOVRa8b4Rzrip0ZVWQJhgbQAsnqlIx75qgpTRVo1hRgVceCh0A1pQLAc5qeUIu_rjj4noIHuI82a4eJ-zttK8Hi_X_ScS2fhp2daVKXnG1Auf_An-Xbx-Vz9JqfsQ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Khatami, Mehrdad</creator><creator>Khatami, Sanaz</creator><creator>Mosazade, Farideh</creator><creator>Raisi, Mahammadali</creator><creator>Haghighat, Mojtaba</creator><creator>Sabaghan, Mohamad</creator><creator>Yaghoubi, Sajad</creator><creator>Sarani, Mina</creator><creator>Bamorovat, Mehdi</creator><creator>Malekian, Leila</creator><creator>Naroi, Afsoon</creator><creator>S Varma, Rajender</creator><general>National Institute of Genetic Engineering and Biotechnology</general><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>202001</creationdate><title>Greener synthesis of Rod Shaped Zinc Oxide Nanoparticles using Lilium ledebourii tuber and evaluation of their Leishmanicidal activity</title><author>Khatami, Mehrdad ; Khatami, Sanaz ; Mosazade, Farideh ; Raisi, Mahammadali ; Haghighat, Mojtaba ; Sabaghan, Mohamad ; Yaghoubi, Sajad ; Sarani, Mina ; Bamorovat, Mehdi ; Malekian, Leila ; Naroi, Afsoon ; S Varma, Rajender</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1114-dccf2bbb7587a4d39d9ade82b27640cbfd83397f4057ec4ce58deeb27122eba83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Khatami, Mehrdad</creatorcontrib><creatorcontrib>Khatami, Sanaz</creatorcontrib><creatorcontrib>Mosazade, Farideh</creatorcontrib><creatorcontrib>Raisi, Mahammadali</creatorcontrib><creatorcontrib>Haghighat, Mojtaba</creatorcontrib><creatorcontrib>Sabaghan, Mohamad</creatorcontrib><creatorcontrib>Yaghoubi, Sajad</creatorcontrib><creatorcontrib>Sarani, Mina</creatorcontrib><creatorcontrib>Bamorovat, Mehdi</creatorcontrib><creatorcontrib>Malekian, Leila</creatorcontrib><creatorcontrib>Naroi, Afsoon</creatorcontrib><creatorcontrib>S Varma, Rajender</creatorcontrib><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Iranian journal of biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khatami, Mehrdad</au><au>Khatami, Sanaz</au><au>Mosazade, Farideh</au><au>Raisi, Mahammadali</au><au>Haghighat, Mojtaba</au><au>Sabaghan, Mohamad</au><au>Yaghoubi, Sajad</au><au>Sarani, Mina</au><au>Bamorovat, Mehdi</au><au>Malekian, Leila</au><au>Naroi, Afsoon</au><au>S Varma, Rajender</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Greener synthesis of Rod Shaped Zinc Oxide Nanoparticles using Lilium ledebourii tuber and evaluation of their Leishmanicidal activity</atitle><jtitle>Iranian journal of biotechnology</jtitle><addtitle>Iran J Biotechnol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>18</volume><issue>1</issue><spage>e2196</spage><epage>e2196</epage><pages>e2196-e2196</pages><issn>1728-3043</issn><eissn>2322-2921</eissn><abstract>Nanoparticles (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. Nanoparticles have been used as an antimicrobial agents to inhibit microbial growth.
In view of the strong antimicrobial activity of nanoparticles, the biogenic synthesis and leishmanicidal activity of rod-shaped zinc oxide (R-ZnO) nanoparticles was explored using Lilium ledebourii tuber extract.
The ensuing nanoparticles are characterized by UV-visible spectroscopy, X-ray diffraction and transmission electron microscopy and their leishmanicidal activity evaluated against the Leishmania major (L. major) by MTT assay.
The R-ZnO nanoparticles displayed excellent leishmanicidal activity against the L. major as they significantly inhibited the amastigotes. The IC
values of R-ZnO nanoparticles being ~ 0.001 mg.mL
. R-ZnO nanoparticles can inhibit L. major growth in a dose-dependent manner under in vitro conditions.
A simple, low-cost feasible and eco-friendly procedure was developed for biosynthesis of R-ZnO nanoparticles using natural bioresource that can inhibit human parasite cells growth in a dose-dependent manner under in vitro conditions.</abstract><cop>Iran</cop><pub>National Institute of Genetic Engineering and Biotechnology</pub><pmid>32884950</pmid><doi>10.30498/IJB.2020.119481.2196</doi><oa>free_for_read</oa></addata></record> |
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| title | Greener synthesis of Rod Shaped Zinc Oxide Nanoparticles using Lilium ledebourii tuber and evaluation of their Leishmanicidal activity |
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