Regen med therapeutic opportunities for fighting COVID‐19
This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID‐19. This article addresses why SARS‐CoV‐2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeu...
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| Veröffentlicht in: | Stem cells translational medicine 2021-01, Vol.10 (1), p.5-13 |
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| container_title | Stem cells translational medicine |
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| creator | Atala, Anthony Henn, Alicia Lundberg, Martha Ahsan, Taby Greenberg, Jordan Krukin, Jeff Lynum, Steven Lutz, Cat Cetrulo, Kyle Albanna, Mohammad Pereira, Taciana Eaker, Shannon Hunsberger, Joshua |
| description | This perspective from a Regenerative Medicine Manufacturing Society working group highlights regenerative medicine therapeutic opportunities for fighting COVID‐19. This article addresses why SARS‐CoV‐2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID‐19. We describe animal models that depict the mechanism of action for COVID‐19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at‐risk patients. This article critically evaluates some of the promising regenerative medicine‐based therapies for treating COVID‐19 and presents some of the collective technologies and resources that the scientific community currently has available to confront this pandemic. |
| doi_str_mv | 10.1002/sctm.20-0245 |
| format | Article |
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STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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This article addresses why SARS‐CoV‐2 is so different from other viruses and how regenerative medicine is poised to deliver new therapeutic opportunities to battle COVID‐19. We describe animal models that depict the mechanism of action for COVID‐19 and that may help identify new treatments. Additionally, organoid platforms that can recapitulate some of the physiological properties of human organ systems, such as the lungs and the heart, are discussed as potential platforms that may prove useful in rapidly screening new drugs and identifying at‐risk patients. 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| subjects | Animal models Animals Clinical trials Coronaviruses COVID-19 COVID-19 - therapy Cytokine storm Disease transmission Drug screening Gene expression Humans Infections Lungs Medical laboratories Medical research Medicine mesenchymal stromal/stem cells Organoids Pandemics Pathogenesis Pneumonia Regenerative medicine Regenerative Medicine - methods Regenerative Medicine - trends Respiratory distress syndrome SARS-CoV-2 Sepsis Severe acute respiratory syndrome coronavirus 2 Stem cells Viruses |
| title | Regen med therapeutic opportunities for fighting COVID‐19 |
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