Risk of transmission of severe acute respiratory syndrome coronavirus 2 by transfusion: A literature review
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus responsible for coronavirus disease 2019 (COVID‐19). The emergence of this virus in Wuhan, China, at the end of 2019 and its worldwide spread to reach the pandemic stage has raised concerns about the possible r...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2020-12, Vol.60 (12), p.3046-3054 |
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| creator | Leblanc, Jean‐François Germain, Marc Delage, Gilles OʼBrien, Sheila Drews, Steven J. Lewin, Antoine |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus responsible for coronavirus disease 2019 (COVID‐19). The emergence of this virus in Wuhan, China, at the end of 2019 and its worldwide spread to reach the pandemic stage has raised concerns about the possible risk that it might be transmissible by transfusion. This theoretical risk is further supported by reports of the detection of viral RNA in the blood of some infected individuals. To further address this risk, a thorough PubMed literature search was performed to systematically identify studies reporting data on the detection of SARS‐CoV‐2 RNA in blood or its components. Complementary searches were done to identify articles reporting data on the in vitro infectivity of blood components. At least 23 articles presenting data on the detection of SARS‐CoV‐2 RNA in blood, plasma, or serum were identified. Of these, three studies reported on blood donors with COVID‐19 infection identified after donation, and no cases of transfusion transmission were identified. A few studies mentioned results of in vitro infectivity assays of blood components in permissive cell lines, none of which were able to detect infectious virus in blood or its components. Complementary searches have identified reports demonstrating that the correlation between the presence of viral RNA in a biologic sample and infectivity requires a minimal RNA load, which is rarely, if ever, observed in blood components. Overall, the available evidence suggests that the risk of transmission of SARS‐CoV‐2 by transfusion remains theoretical. |
| doi_str_mv | 10.1111/trf.16056 |
| format | Article |
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The emergence of this virus in Wuhan, China, at the end of 2019 and its worldwide spread to reach the pandemic stage has raised concerns about the possible risk that it might be transmissible by transfusion. This theoretical risk is further supported by reports of the detection of viral RNA in the blood of some infected individuals. To further address this risk, a thorough PubMed literature search was performed to systematically identify studies reporting data on the detection of SARS‐CoV‐2 RNA in blood or its components. Complementary searches were done to identify articles reporting data on the in vitro infectivity of blood components. At least 23 articles presenting data on the detection of SARS‐CoV‐2 RNA in blood, plasma, or serum were identified. Of these, three studies reported on blood donors with COVID‐19 infection identified after donation, and no cases of transfusion transmission were identified. A few studies mentioned results of in vitro infectivity assays of blood components in permissive cell lines, none of which were able to detect infectious virus in blood or its components. Complementary searches have identified reports demonstrating that the correlation between the presence of viral RNA in a biologic sample and infectivity requires a minimal RNA load, which is rarely, if ever, observed in blood components. Overall, the available evidence suggests that the risk of transmission of SARS‐CoV‐2 by transfusion remains theoretical.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.16056</identifier><identifier>PMID: 32798237</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Blood ; Blood & organ donations ; Blood Donors ; Blood Transfusion ; CD4-Positive T-Lymphocytes - virology ; Cell Line ; Cell lines ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - epidemiology ; COVID-19 - transmission ; Disease transmission ; Endothelial Cells - virology ; Humans ; Infectivity ; Literature reviews ; Pandemics ; Respiratory diseases ; Review ; Ribonucleic acid ; Risk ; RNA ; RNA, Viral - blood ; RNAemia ; SARS-CoV-2 - isolation & purification ; SARS-CoV-2 - physiology ; SARS‐CoV‐2 ; Searching ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Transfusion ; Transfusion Reaction - epidemiology ; Vero cell lines ; Viral diseases ; Viral Load ; Viremia - blood ; Viremia - epidemiology ; Viremia - transmission ; Virus Cultivation ; Viruses</subject><ispartof>Transfusion (Philadelphia, Pa.), 2020-12, Vol.60 (12), p.3046-3054</ispartof><rights>2020 AABB</rights><rights>2020 AABB.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-87fc4aaccd65895ebc8671dea019397a8945d7f7426e634116b3a1ed712678f93</citedby><cites>FETCH-LOGICAL-c4436-87fc4aaccd65895ebc8671dea019397a8945d7f7426e634116b3a1ed712678f93</cites><orcidid>0000-0003-2519-1109 ; 0000-0003-1748-4198</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.16056$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.16056$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32798237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leblanc, Jean‐François</creatorcontrib><creatorcontrib>Germain, Marc</creatorcontrib><creatorcontrib>Delage, Gilles</creatorcontrib><creatorcontrib>OʼBrien, Sheila</creatorcontrib><creatorcontrib>Drews, Steven J.</creatorcontrib><creatorcontrib>Lewin, Antoine</creatorcontrib><title>Risk of transmission of severe acute respiratory syndrome coronavirus 2 by transfusion: A literature review</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus responsible for coronavirus disease 2019 (COVID‐19). The emergence of this virus in Wuhan, China, at the end of 2019 and its worldwide spread to reach the pandemic stage has raised concerns about the possible risk that it might be transmissible by transfusion. This theoretical risk is further supported by reports of the detection of viral RNA in the blood of some infected individuals. To further address this risk, a thorough PubMed literature search was performed to systematically identify studies reporting data on the detection of SARS‐CoV‐2 RNA in blood or its components. Complementary searches were done to identify articles reporting data on the in vitro infectivity of blood components. At least 23 articles presenting data on the detection of SARS‐CoV‐2 RNA in blood, plasma, or serum were identified. Of these, three studies reported on blood donors with COVID‐19 infection identified after donation, and no cases of transfusion transmission were identified. A few studies mentioned results of in vitro infectivity assays of blood components in permissive cell lines, none of which were able to detect infectious virus in blood or its components. Complementary searches have identified reports demonstrating that the correlation between the presence of viral RNA in a biologic sample and infectivity requires a minimal RNA load, which is rarely, if ever, observed in blood components. Overall, the available evidence suggests that the risk of transmission of SARS‐CoV‐2 by transfusion remains theoretical.</description><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood Donors</subject><subject>Blood Transfusion</subject><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - transmission</subject><subject>Disease transmission</subject><subject>Endothelial Cells - virology</subject><subject>Humans</subject><subject>Infectivity</subject><subject>Literature reviews</subject><subject>Pandemics</subject><subject>Respiratory diseases</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>Risk</subject><subject>RNA</subject><subject>RNA, Viral - blood</subject><subject>RNAemia</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>SARS-CoV-2 - physiology</subject><subject>SARS‐CoV‐2</subject><subject>Searching</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Transfusion</subject><subject>Transfusion Reaction - epidemiology</subject><subject>Vero cell lines</subject><subject>Viral diseases</subject><subject>Viral Load</subject><subject>Viremia - blood</subject><subject>Viremia - epidemiology</subject><subject>Viremia - transmission</subject><subject>Virus Cultivation</subject><subject>Viruses</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFrFDEUx4NY7Fo9-AUk4EUP0-YlmWTiQSilVaEglHoO2cwbTTs7WZOZLfPtm3VqUaG5hJDf-72X_Al5A-wYyjoZU3cMitXqGVlBLXTFjamfkxVjEioAwQ_Jy5xvGGPcMHhBDgXXpuFCr8jtVci3NHZ0TG7Im5BziMP-nHGHCanz04g0Yd6G5MaYZprnoU1xg9THFAe3C2nKlNP1vCi6aW_4SE9pH0YsNVPa1-8C3r0iB53rM75-2I_I94vz67Mv1eW3z1_PTi8rL6VQVaM7L53zvlV1Y2pc-0ZpaNExMMJo1xhZt7rTkitUQgKotXCArQaudNMZcUQ-Ld7ttN5g63Eok_V2m8LGpdlGF-y_N0P4aX_EndVSATd1Ebx_EKT4a8I82vIxHvveDRinbLkUUurSDAr67j_0Jk5pKM8rlNKqBl2LQn1YKJ9izgm7x2GA2X2EtkRof0dY2Ld_T_9I_smsACcLcBd6nJ822euri0V5D2ntp8s</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Leblanc, Jean‐François</creator><creator>Germain, Marc</creator><creator>Delage, Gilles</creator><creator>OʼBrien, Sheila</creator><creator>Drews, Steven J.</creator><creator>Lewin, Antoine</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2519-1109</orcidid><orcidid>https://orcid.org/0000-0003-1748-4198</orcidid></search><sort><creationdate>202012</creationdate><title>Risk of transmission of severe acute respiratory syndrome coronavirus 2 by transfusion: A literature review</title><author>Leblanc, Jean‐François ; Germain, Marc ; Delage, Gilles ; OʼBrien, Sheila ; Drews, Steven J. ; Lewin, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-87fc4aaccd65895ebc8671dea019397a8945d7f7426e634116b3a1ed712678f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood Donors</topic><topic>Blood Transfusion</topic><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Cell Line</topic><topic>Cell lines</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - transmission</topic><topic>Disease transmission</topic><topic>Endothelial Cells - virology</topic><topic>Humans</topic><topic>Infectivity</topic><topic>Literature reviews</topic><topic>Pandemics</topic><topic>Respiratory diseases</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>Risk</topic><topic>RNA</topic><topic>RNA, Viral - blood</topic><topic>RNAemia</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>SARS-CoV-2 - physiology</topic><topic>SARS‐CoV‐2</topic><topic>Searching</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Transfusion</topic><topic>Transfusion Reaction - epidemiology</topic><topic>Vero cell lines</topic><topic>Viral diseases</topic><topic>Viral Load</topic><topic>Viremia - blood</topic><topic>Viremia - epidemiology</topic><topic>Viremia - transmission</topic><topic>Virus Cultivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leblanc, Jean‐François</creatorcontrib><creatorcontrib>Germain, Marc</creatorcontrib><creatorcontrib>Delage, Gilles</creatorcontrib><creatorcontrib>OʼBrien, Sheila</creatorcontrib><creatorcontrib>Drews, Steven J.</creatorcontrib><creatorcontrib>Lewin, Antoine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leblanc, Jean‐François</au><au>Germain, Marc</au><au>Delage, Gilles</au><au>OʼBrien, Sheila</au><au>Drews, Steven J.</au><au>Lewin, Antoine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of transmission of severe acute respiratory syndrome coronavirus 2 by transfusion: A literature review</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2020-12</date><risdate>2020</risdate><volume>60</volume><issue>12</issue><spage>3046</spage><epage>3054</epage><pages>3046-3054</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a novel human coronavirus responsible for coronavirus disease 2019 (COVID‐19). The emergence of this virus in Wuhan, China, at the end of 2019 and its worldwide spread to reach the pandemic stage has raised concerns about the possible risk that it might be transmissible by transfusion. This theoretical risk is further supported by reports of the detection of viral RNA in the blood of some infected individuals. To further address this risk, a thorough PubMed literature search was performed to systematically identify studies reporting data on the detection of SARS‐CoV‐2 RNA in blood or its components. Complementary searches were done to identify articles reporting data on the in vitro infectivity of blood components. At least 23 articles presenting data on the detection of SARS‐CoV‐2 RNA in blood, plasma, or serum were identified. Of these, three studies reported on blood donors with COVID‐19 infection identified after donation, and no cases of transfusion transmission were identified. A few studies mentioned results of in vitro infectivity assays of blood components in permissive cell lines, none of which were able to detect infectious virus in blood or its components. Complementary searches have identified reports demonstrating that the correlation between the presence of viral RNA in a biologic sample and infectivity requires a minimal RNA load, which is rarely, if ever, observed in blood components. Overall, the available evidence suggests that the risk of transmission of SARS‐CoV‐2 by transfusion remains theoretical.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32798237</pmid><doi>10.1111/trf.16056</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2519-1109</orcidid><orcidid>https://orcid.org/0000-0003-1748-4198</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Blood Blood & organ donations Blood Donors Blood Transfusion CD4-Positive T-Lymphocytes - virology Cell Line Cell lines Coronaviridae Coronaviruses COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - transmission Disease transmission Endothelial Cells - virology Humans Infectivity Literature reviews Pandemics Respiratory diseases Review Ribonucleic acid Risk RNA RNA, Viral - blood RNAemia SARS-CoV-2 - isolation & purification SARS-CoV-2 - physiology SARS‐CoV‐2 Searching Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Transfusion Transfusion Reaction - epidemiology Vero cell lines Viral diseases Viral Load Viremia - blood Viremia - epidemiology Viremia - transmission Virus Cultivation Viruses |
| title | Risk of transmission of severe acute respiratory syndrome coronavirus 2 by transfusion: A literature review |
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