PTEN Is Required for The Anti-Epileptic Effects of AMPA Receptor Antagonists in Chronic Epileptic Rats

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is one of the ligand-gated ion channels for glutamate, which is an important player in the generation and spread of seizures. The efficacy of AMPAR functionality is regulated by the trafficking, synaptic targeting, and phosphoryla...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (16), p.5643
Hauptverfasser:	Kim, Ji-Eun, Park, Hana, Lee, Ji-Eun, Kim, Tae-Hyun, Kang, Tae-Cheon
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT1 protein Animals Benzodiazepines - pharmacology Benzodiazepines - therapeutic use Bisperoxovanadium Chromosome 10 Chromosomes Chronic Disease Convulsions & seizures Down-Regulation - drug effects Epilepsy Epilepsy - drug therapy Epilepsy - metabolism Hippocampus Hippocampus - metabolism Homology Ion channels Ion channels (ligand-gated) Kinases Male Models, Biological NF-kappa B - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - metabolism PTEN protein Pyridones - pharmacology Pyridones - therapeutic use Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Recording sessions Rodents Seizures Tensin Up-Regulation - drug effects α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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