Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020
The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention...
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| Veröffentlicht in: | International journal of environmental research and public health 2020-08, Vol.17 (16), p.5998 |
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| creator | Campisi, Giuseppina Mauceri, Rodolfo Bertoldo, Francesco Bettini, Giordana Biasotto, Matteo Colella, Giuseppe Consolo, Ugo Di Fede, Olga Favia, Gianfranco Fusco, Vittorio Gabriele, Mario Lo Casto, Antonio Lo Muzio, Lorenzo Marcianò, Antonia Mascitti, Marco Meleti, Marco Mignogna, Michele D Oteri, Giacomo Panzarella, Vera Romeo, Umberto Santarelli, Andrea Vescovi, Paolo Marchetti, Claudio Bedogni, Alberto |
| description | The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference-held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)-after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended. |
| doi_str_mv | 10.3390/ijerph17165998 |
| format | Article |
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The present paper reports the update of the conclusions from the Consensus Conference-held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)-after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph17165998</identifier><identifier>PMID: 32824826</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antiangiogenics ; Biomedical materials ; Biopsy ; Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw - epidemiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control ; Bisphosphonates ; Bone Density Conservation Agents ; Cancer therapies ; Conference Report ; Decision making ; Dentistry ; Dentists ; Diagnosis ; Diphosphonates ; Disease prevention ; Fistula ; Humans ; Hypotheses ; Immunotherapy ; Italy ; Maxillofacial ; Medicine ; Monoclonal antibodies ; Oral hygiene ; Osteonecrosis ; Osteoporosis ; Pathology ; Prevention ; Quality of Life ; Risk ; Risk factors ; Risk management ; Surgeons ; Targeted cancer therapy</subject><ispartof>International journal of environmental research and public health, 2020-08, Vol.17 (16), p.5998</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campisi, Giuseppina</au><au>Mauceri, Rodolfo</au><au>Bertoldo, Francesco</au><au>Bettini, Giordana</au><au>Biasotto, Matteo</au><au>Colella, Giuseppe</au><au>Consolo, Ugo</au><au>Di Fede, Olga</au><au>Favia, Gianfranco</au><au>Fusco, Vittorio</au><au>Gabriele, Mario</au><au>Lo Casto, Antonio</au><au>Lo Muzio, Lorenzo</au><au>Marcianò, Antonia</au><au>Mascitti, Marco</au><au>Meleti, Marco</au><au>Mignogna, Michele D</au><au>Oteri, Giacomo</au><au>Panzarella, Vera</au><au>Romeo, Umberto</au><au>Santarelli, Andrea</au><au>Vescovi, Paolo</au><au>Marchetti, Claudio</au><au>Bedogni, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2020-08-18</date><risdate>2020</risdate><volume>17</volume><issue>16</issue><spage>5998</spage><pages>5998-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference-held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)-after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32824826</pmid><doi>10.3390/ijerph17165998</doi><orcidid>https://orcid.org/0000-0002-4008-6502</orcidid><orcidid>https://orcid.org/0000-0001-5557-3285</orcidid><orcidid>https://orcid.org/0000-0003-2439-2187</orcidid><orcidid>https://orcid.org/0000-0003-4218-3354</orcidid><orcidid>https://orcid.org/0000-0001-6339-6020</orcidid><orcidid>https://orcid.org/0000-0003-4742-4508</orcidid><orcidid>https://orcid.org/0000-0002-5175-7340</orcidid><orcidid>https://orcid.org/0000-0002-4178-4257</orcidid><orcidid>https://orcid.org/0000-0002-9443-0495</orcidid><orcidid>https://orcid.org/0000-0002-4314-3277</orcidid><orcidid>https://orcid.org/0000-0003-4633-4893</orcidid><orcidid>https://orcid.org/0000-0002-5562-7420</orcidid><orcidid>https://orcid.org/0000-0002-0941-1645</orcidid><orcidid>https://orcid.org/0000-0002-7304-3752</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2020-08, Vol.17 (16), p.5998 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7460511 |
| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antiangiogenics Biomedical materials Biopsy Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis Bisphosphonate-Associated Osteonecrosis of the Jaw - epidemiology Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control Bisphosphonates Bone Density Conservation Agents Cancer therapies Conference Report Decision making Dentistry Dentists Diagnosis Diphosphonates Disease prevention Fistula Humans Hypotheses Immunotherapy Italy Maxillofacial Medicine Monoclonal antibodies Oral hygiene Osteonecrosis Osteoporosis Pathology Prevention Quality of Life Risk Risk factors Risk management Surgeons Targeted cancer therapy |
| title | Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T21%3A21%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Medication-Related%20Osteonecrosis%20of%20Jaws%20(MRONJ)%20Prevention%20and%20Diagnosis:%20Italian%20Consensus%20Update%202020&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Campisi,%20Giuseppina&rft.date=2020-08-18&rft.volume=17&rft.issue=16&rft.spage=5998&rft.pages=5998-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph17165998&rft_dat=%3Cproquest_pubme%3E2436268621%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2436268621&rft_id=info:pmid/32824826&rfr_iscdi=true |