Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis

Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter intestinal epithelium permeability during colitis remains elusive. Here, we demonstrate...

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Veröffentlicht in:	Biomedicines 2020-08, Vol.8 (8), p.275, Article 275
Hauptverfasser:	Lin, Elliot Yi-Hsin, Lai, Hsuan-Ju, Cheng, Yuan-Kai, Leong, Kai-Quan, Cheng, Li-Chieh, Chou, Yi-Chun, Peng, Yu-Chun, Hsu, Yi-Hsuan, Chiang, Hao-Sen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens junctions Animal models Apoptosis Biochemistry & Molecular Biology Colitis Colon Deoxyribonuclease Dextran Dextran sulfate Digestive system DNase I Drinking water DSS/TNBS-induced colitis Epithelial cells Epithelium Filaments Gastrointestinal tract Inflammation Inflammatory bowel disease Inflammatory bowel diseases intestinal barrier integrity Intestine Intravenous administration Laboratory animals Life Sciences & Biomedicine Medicine, Research & Experimental Microbiota Mucosa neutrophil extracellular traps (NETs) Neutrophils Pathogenesis Permeability Pharmacology & Pharmacy Proteins Research & Experimental Medicine Rodents Science & Technology Sulfonic acid Tight junctions
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