Targeting poor proteasomal function with radioiodine eliminates CT26 colon cancer stem cells resistant to bortezomib therapy

We tested the hypothesis that tumor response to conventional bortezomib (BTZ) treatment is enhanced by targeted radiotherapy of resistant cancer stem cells (CSCs) that have characteristically poor proteasome function. This was accomplished by augmenting 131 I uptake through expression of a sodium-io...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.14308, Article 14308
Hauptverfasser:	Lee, Jin Hee, Jung, Kyung-Ho, Park, Jin Won, Moon, Seung Hwan, Cho, Young Seok, Lee, Kyung-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 692/4028 Animals Bortezomib Cell Line, Tumor Colorectal cancer Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Drug Synergism Emission measurements Humanities and Social Sciences Inhibitor drugs Iodides Iodine radioisotopes Iodine Radioisotopes - administration & dosage Iodine Radioisotopes - metabolism Methylene blue Mice Mice, Inbred BALB C multidisciplinary Nanoparticles Neoplasm Transplantation Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Ornithine Decarboxylase Photodegradation Photosensitization Pollutants Proteasome Inhibitors Proteasomes Recombination Science Science (multidisciplinary) Stem cells Sunlight Symporters Targeted cancer therapy Tumors Wastewater
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