Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase

Many RNA viruses create specialized membranes for genome replication by manipulating host lipid metabolism and trafficking, but in most cases, we do not know the molecular mechanisms responsible or how specific lipids may impact the associated membrane and viral process. For example, hepatitis C vir...

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Veröffentlicht in:	The Journal of biological chemistry 2020-08, Vol.295 (35), p.12426-12436
Hauptverfasser:	Tallorin, Lorillee, Villareal, Valerie A., Hsia, Chih-Yun, Rodgers, Mary A., Burri, Dominique J., Pfeil, Marc-Philipp, Llopis, Paula Montero, Lindenbach, Brett D., Yang, Priscilla L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor cholesterol metabolism desmosterol Hepacivirus - enzymology Hepacivirus - genetics hepatitis C virus (HCV) host–pathogen interaction Humans lipid environment Lipid Metabolism membrane lipid Membrane Lipids - genetics Membrane Lipids - metabolism membrane remodeling Microbiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oxidoreductases Acting on CH-CH Group Donors - genetics Oxidoreductases Acting on CH-CH Group Donors - metabolism post-translational modification (PTM) Proteolysis RNA replication RNA, Viral - biosynthesis RNA, Viral - genetics Serine Proteases - genetics Serine Proteases - metabolism Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism viral protease viral replication
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