Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model

Hepatitis B, a viral infection that affects the liver, is thought to affect over 257 million people worldwide, and long-term infection can lead to life-threatening issues such as cirrhosis or liver cancer. Chronic hepatitis B develops by the interaction between hepatitis B virus (HBV) and host immun...

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Veröffentlicht in:	The Journal of biological chemistry 2020-08, Vol.295 (35), p.12449-12460
Hauptverfasser:	Kakizaki, Masatoshi, Yamamoto, Yuichiro, Otsuka, Motoyuki, Kitamura, Kouichi, Ito, Masatoshi, Kawai, Hideki Derek, Muramatsu, Masamichi, Kagawa, Tatehiro, Kotani, Ai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - metabolism B7-H1 Antigen - genetics B7-H1 Antigen - metabolism dendritic cell dendritic cells Disease Models, Animal extracellular vesicles Extracellular Vesicles - genetics Extracellular Vesicles - pathology Extracellular Vesicles - virology HBV Hep B Hep G2 Cells hepatitis B virus (HBV Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatitis B, Chronic - genetics Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - pathology Humans hydrodynamic HBV transfection mouse model Hydrodynamics immunosuppression Lectins, C-Type - genetics Lectins, C-Type - metabolism Mice Microbiology PD-L1 Transfection viral immunology
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