A single molecular descriptor to predict solution behavior of therapeutic antibodies

Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of developable mAb drug candidates with optimal manufacturability, stability, and delivery attributes remains elusive. Poor solution behavior, which manifests as high solution viscosity or opalescence, profoundly a...

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Veröffentlicht in:	Science advances 2020-08, Vol.6 (32), p.eabb0372
Hauptverfasser:	Kingsbury, Jonathan S, Saini, Amandeep, Auclair, Sarah Marie, Fu, Li, Lantz, Michaela M, Halloran, Kevin T, Calero-Rubio, Cesar, Schwenger, Walter, Airiau, Christian Y, Zhang, Jifeng, Gokarn, Yatin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - therapeutic use Biophysics Coronavirus Diffusion Health and Medicine Humans Hydrophobic and Hydrophilic Interactions SciAdv r-articles Viscosity
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