12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1

Patients with diabetes develop endothelial dysfunction shortly after diabetes onset that progresses to vascular disease underlying the majority of diabetes-associated comorbidities. Increased lipid peroxidation, mitochondrial calcium overload, and mitochondrial dysfunction are characteristics of dys...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2020-09, Vol.130 (9), p.4999-5010
Hauptverfasser:	Otto, Mandy, Bucher, Clarissa, Liu, Wantao, Müller, Melanie, Schmidt, Tobias, Kardell, Marina, Driessen, Marvin Noel, Rossaint, Jan, Gross, Eric R, Wagner, Nana-Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonate 12-lipoxygenase Biomedical research Calcium (mitochondrial) Calcium influx Calcium Signaling Capsaicin receptors Cardiovascular disease Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - pathology Diabetic Angiopathies - genetics Diabetic Angiopathies - metabolism Diabetic Angiopathies - pathology Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Female Glucose Homeostasis Hydroxyeicosatetraenoic Acids - metabolism Hyperglycemia Lipid peroxidation Lipids Male Mice Mice, Knockout Mitochondria Molecular weight Nitric oxide Peptides Plasma Proteins Respiration Rodents Transient receptor potential proteins TRPV Cation Channels - genetics TRPV Cation Channels - metabolism Vascular diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!