Catalytic Cycloisomerization onto a Carbonyl Oxygen

We have found that terminal N-vinylindoles bearing cycloalkanone substituents are excellent hydrogen atom acceptors, generating α-aminyl radicals with a variety of catalysts (Co­(II)/H2 or Co­(III)Cl precatalysts with silane reductants). These radicals can be converted to internal vinylindoles but e...

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Veröffentlicht in:	Organic letters 2020-08, Vol.22 (15), p.6171-6176
Hauptverfasser:	Shi, Shicheng, Kuo, Jonathan L, Chen, Tao, Norton, Jack R
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Cyclization Hydrogen - chemistry Isomerism Molecular Structure Oxygen - chemistry Silanes - chemistry
Online-Zugang:	Volltext
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