Investigation of Lipid Profile and Clinical Manifestations in SCA Children
Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. W...
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creator | Fonseca, Cleverson Alves Carvalho, Suellen Pinheiro de Oliveira, Rodrigo Mota Nascimento, Valma Maria Lopes Rocha, Larissa Carneiro Gonçalves, Marilda Souza Figueiredo, Camylla Vilas Boas Aleluia, Milena Magalhães Oliveira, Antonio Mateus de Jesus Neres, Joelma Santana dos Santos Fernandes, Camila Felix de Lima Santiago, Rayra Pereira Yahouédéhou, Sètondji Cocou Modeste Alexandre da Guarda, Caroline Conceição Fiuza, Luciana Magalhães |
description | Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA. |
doi_str_mv | 10.1155/2020/8842362 |
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Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2020/8842362</identifier><identifier>PMID: 32884585</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Anemia ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - metabolism ; Antilipemic agents ; Atherosclerosis ; Bacterial pneumonia ; Blood ; Care and treatment ; Cholesterol ; Cholesterol - analysis ; Cholesterol, HDL - analysis ; Cholesterol, LDL - analysis ; Complications ; Cross-Sectional Studies ; Density ; Female ; Guardians ; Hematology ; Hemoglobin ; Hemolysis ; High density lipoprotein ; Humans ; Hypertension ; Investigations ; Laboratories ; Leg ulcers ; Lipids ; Lipoproteins ; Low density lipoprotein ; Low density lipoproteins ; Male ; Metabolites ; Pain ; Parameters ; Patients ; Pediatrics ; Phenotypes ; Pneumonia ; Pulmonary hypertension ; Severity of Illness Index ; Sickle cell anemia ; Sickle cell disease ; Software ; Triglycerides ; Ulcers ; Variables ; Vascular diseases</subject><ispartof>Disease markers, 2020, Vol.2020 (2020), p.1-10</ispartof><rights>Copyright © 2020 Caroline Conceição da Guarda et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Caroline Conceição da Guarda et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Caroline Conceição da Guarda et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-7f57815ab421ed1634b60bdfb7f1954f884061648b7622c61d2a0811f69a71b73</citedby><cites>FETCH-LOGICAL-c499t-7f57815ab421ed1634b60bdfb7f1954f884061648b7622c61d2a0811f69a71b73</cites><orcidid>0000-0003-3000-1437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455829/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455829/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32884585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Himmerich, Hubertus</contributor><contributor>Hubertus Himmerich</contributor><creatorcontrib>Fonseca, Cleverson Alves</creatorcontrib><creatorcontrib>Carvalho, Suellen Pinheiro</creatorcontrib><creatorcontrib>de Oliveira, Rodrigo Mota</creatorcontrib><creatorcontrib>Nascimento, Valma Maria Lopes</creatorcontrib><creatorcontrib>Rocha, Larissa Carneiro</creatorcontrib><creatorcontrib>Gonçalves, Marilda Souza</creatorcontrib><creatorcontrib>Figueiredo, Camylla Vilas Boas</creatorcontrib><creatorcontrib>Aleluia, Milena Magalhães</creatorcontrib><creatorcontrib>Oliveira, Antonio Mateus de Jesus</creatorcontrib><creatorcontrib>Neres, Joelma Santana dos Santos</creatorcontrib><creatorcontrib>Fernandes, Camila Felix de Lima</creatorcontrib><creatorcontrib>Santiago, Rayra Pereira</creatorcontrib><creatorcontrib>Yahouédéhou, Sètondji Cocou Modeste Alexandre</creatorcontrib><creatorcontrib>da Guarda, Caroline Conceição</creatorcontrib><creatorcontrib>Fiuza, Luciana Magalhães</creatorcontrib><title>Investigation of Lipid Profile and Clinical Manifestations in SCA Children</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.</description><subject>Adolescent</subject><subject>Anemia</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - metabolism</subject><subject>Antilipemic agents</subject><subject>Atherosclerosis</subject><subject>Bacterial pneumonia</subject><subject>Blood</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Cholesterol - analysis</subject><subject>Cholesterol, HDL - analysis</subject><subject>Cholesterol, LDL - analysis</subject><subject>Complications</subject><subject>Cross-Sectional Studies</subject><subject>Density</subject><subject>Female</subject><subject>Guardians</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Hemolysis</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Investigations</subject><subject>Laboratories</subject><subject>Leg ulcers</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Metabolites</subject><subject>Pain</subject><subject>Parameters</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Phenotypes</subject><subject>Pneumonia</subject><subject>Pulmonary hypertension</subject><subject>Severity of Illness Index</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><subject>Software</subject><subject>Triglycerides</subject><subject>Ulcers</subject><subject>Variables</subject><subject>Vascular diseases</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqN0UtvEzEUBWALUdFQ2LFGltggwVC_HxukaAS0VRBIwNryzNiJK8cOdlLEv8chaQusWHnhz8f36gDwDKM3GHN-ThBB50oxQgV5AGZYSd4pQdFDMENEqg4Rhk7B41qvEcJEM_0InFLSHnDFZ-DqMt24ug1Luw05wezhImzCBD-X7EN00KYJ9jGkMNoIP9oUfNO_bYUhwS_9HParEKfi0hNw4m2s7unxPAPf3r_72l90i08fLvv5ohuZ1ttOei4V5nZgBLsJC8oGgYbJD9JjzZlvkyGBBVODFISMAk_EIoWxF9pKPEh6Bt4ecje7Ye2m0aVtsdFsSljb8tNkG8zfNymszDLfGMk4V0S3gJfHgJK_79o-Zh3q6GK0yeVdNYQxxASjUjT64h96nXcltfWaooq3YSW-V0sbnQnJ5_bvuA81c0E1kVRz3tTrgxpLrrU4fzcyRmZfpdlXaY5VNv78zzXv8G13Dbw6gFVIk_0R_jPONeO8vdeYM4w0_QWdXq00</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Fonseca, Cleverson Alves</creator><creator>Carvalho, Suellen Pinheiro</creator><creator>de Oliveira, Rodrigo Mota</creator><creator>Nascimento, Valma Maria Lopes</creator><creator>Rocha, Larissa Carneiro</creator><creator>Gonçalves, Marilda Souza</creator><creator>Figueiredo, Camylla Vilas Boas</creator><creator>Aleluia, Milena Magalhães</creator><creator>Oliveira, Antonio Mateus de Jesus</creator><creator>Neres, Joelma Santana dos Santos</creator><creator>Fernandes, Camila Felix de Lima</creator><creator>Santiago, Rayra Pereira</creator><creator>Yahouédéhou, Sètondji Cocou Modeste Alexandre</creator><creator>da Guarda, Caroline Conceição</creator><creator>Fiuza, Luciana Magalhães</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3000-1437</orcidid></search><sort><creationdate>2020</creationdate><title>Investigation of Lipid Profile and Clinical Manifestations in SCA Children</title><author>Fonseca, Cleverson Alves ; Carvalho, Suellen Pinheiro ; de Oliveira, Rodrigo Mota ; Nascimento, Valma Maria Lopes ; Rocha, Larissa Carneiro ; Gonçalves, Marilda Souza ; Figueiredo, Camylla Vilas Boas ; Aleluia, Milena Magalhães ; Oliveira, Antonio Mateus de Jesus ; Neres, Joelma Santana dos Santos ; Fernandes, Camila Felix de Lima ; Santiago, Rayra Pereira ; Yahouédéhou, Sètondji Cocou Modeste Alexandre ; da Guarda, Caroline Conceição ; Fiuza, Luciana Magalhães</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-7f57815ab421ed1634b60bdfb7f1954f884061648b7622c61d2a0811f69a71b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Anemia</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - metabolism</topic><topic>Antilipemic agents</topic><topic>Atherosclerosis</topic><topic>Bacterial pneumonia</topic><topic>Blood</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Cholesterol - analysis</topic><topic>Cholesterol, HDL - analysis</topic><topic>Cholesterol, LDL - analysis</topic><topic>Complications</topic><topic>Cross-Sectional Studies</topic><topic>Density</topic><topic>Female</topic><topic>Guardians</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Hemolysis</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Investigations</topic><topic>Laboratories</topic><topic>Leg ulcers</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Metabolites</topic><topic>Pain</topic><topic>Parameters</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Phenotypes</topic><topic>Pneumonia</topic><topic>Pulmonary hypertension</topic><topic>Severity of Illness Index</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><topic>Software</topic><topic>Triglycerides</topic><topic>Ulcers</topic><topic>Variables</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fonseca, Cleverson Alves</creatorcontrib><creatorcontrib>Carvalho, Suellen Pinheiro</creatorcontrib><creatorcontrib>de Oliveira, Rodrigo Mota</creatorcontrib><creatorcontrib>Nascimento, Valma Maria Lopes</creatorcontrib><creatorcontrib>Rocha, Larissa Carneiro</creatorcontrib><creatorcontrib>Gonçalves, Marilda Souza</creatorcontrib><creatorcontrib>Figueiredo, Camylla Vilas Boas</creatorcontrib><creatorcontrib>Aleluia, Milena Magalhães</creatorcontrib><creatorcontrib>Oliveira, Antonio Mateus de Jesus</creatorcontrib><creatorcontrib>Neres, Joelma Santana dos Santos</creatorcontrib><creatorcontrib>Fernandes, Camila Felix de Lima</creatorcontrib><creatorcontrib>Santiago, Rayra Pereira</creatorcontrib><creatorcontrib>Yahouédéhou, Sètondji Cocou Modeste Alexandre</creatorcontrib><creatorcontrib>da Guarda, Caroline Conceição</creatorcontrib><creatorcontrib>Fiuza, Luciana Magalhães</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fonseca, Cleverson Alves</au><au>Carvalho, Suellen Pinheiro</au><au>de Oliveira, Rodrigo Mota</au><au>Nascimento, Valma Maria Lopes</au><au>Rocha, Larissa Carneiro</au><au>Gonçalves, Marilda Souza</au><au>Figueiredo, Camylla Vilas Boas</au><au>Aleluia, Milena Magalhães</au><au>Oliveira, Antonio Mateus de Jesus</au><au>Neres, Joelma Santana dos Santos</au><au>Fernandes, Camila Felix de Lima</au><au>Santiago, Rayra Pereira</au><au>Yahouédéhou, Sètondji Cocou Modeste Alexandre</au><au>da Guarda, Caroline Conceição</au><au>Fiuza, Luciana Magalhães</au><au>Himmerich, Hubertus</au><au>Hubertus Himmerich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of Lipid Profile and Clinical Manifestations in SCA Children</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32884585</pmid><doi>10.1155/2020/8842362</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3000-1437</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Anemia Anemia, Sickle Cell - complications Anemia, Sickle Cell - metabolism Antilipemic agents Atherosclerosis Bacterial pneumonia Blood Care and treatment Cholesterol Cholesterol - analysis Cholesterol, HDL - analysis Cholesterol, LDL - analysis Complications Cross-Sectional Studies Density Female Guardians Hematology Hemoglobin Hemolysis High density lipoprotein Humans Hypertension Investigations Laboratories Leg ulcers Lipids Lipoproteins Low density lipoprotein Low density lipoproteins Male Metabolites Pain Parameters Patients Pediatrics Phenotypes Pneumonia Pulmonary hypertension Severity of Illness Index Sickle cell anemia Sickle cell disease Software Triglycerides Ulcers Variables Vascular diseases |
title | Investigation of Lipid Profile and Clinical Manifestations in SCA Children |
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