Investigation of Lipid Profile and Clinical Manifestations in SCA Children

Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. W...

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Veröffentlicht in:Disease markers 2020, Vol.2020 (2020), p.1-10
Hauptverfasser: Fonseca, Cleverson Alves, Carvalho, Suellen Pinheiro, de Oliveira, Rodrigo Mota, Nascimento, Valma Maria Lopes, Rocha, Larissa Carneiro, Gonçalves, Marilda Souza, Figueiredo, Camylla Vilas Boas, Aleluia, Milena Magalhães, Oliveira, Antonio Mateus de Jesus, Neres, Joelma Santana dos Santos, Fernandes, Camila Felix de Lima, Santiago, Rayra Pereira, Yahouédéhou, Sètondji Cocou Modeste Alexandre, da Guarda, Caroline Conceição, Fiuza, Luciana Magalhães
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container_end_page 10
container_issue 2020
container_start_page 1
container_title Disease markers
container_volume 2020
creator Fonseca, Cleverson Alves
Carvalho, Suellen Pinheiro
de Oliveira, Rodrigo Mota
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Gonçalves, Marilda Souza
Figueiredo, Camylla Vilas Boas
Aleluia, Milena Magalhães
Oliveira, Antonio Mateus de Jesus
Neres, Joelma Santana dos Santos
Fernandes, Camila Felix de Lima
Santiago, Rayra Pereira
Yahouédéhou, Sètondji Cocou Modeste Alexandre
da Guarda, Caroline Conceição
Fiuza, Luciana Magalhães
description Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.
doi_str_mv 10.1155/2020/8842362
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Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2020/8842362</identifier><identifier>PMID: 32884585</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Anemia ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - metabolism ; Antilipemic agents ; Atherosclerosis ; Bacterial pneumonia ; Blood ; Care and treatment ; Cholesterol ; Cholesterol - analysis ; Cholesterol, HDL - analysis ; Cholesterol, LDL - analysis ; Complications ; Cross-Sectional Studies ; Density ; Female ; Guardians ; Hematology ; Hemoglobin ; Hemolysis ; High density lipoprotein ; Humans ; Hypertension ; Investigations ; Laboratories ; Leg ulcers ; Lipids ; Lipoproteins ; Low density lipoprotein ; Low density lipoproteins ; Male ; Metabolites ; Pain ; Parameters ; Patients ; Pediatrics ; Phenotypes ; Pneumonia ; Pulmonary hypertension ; Severity of Illness Index ; Sickle cell anemia ; Sickle cell disease ; Software ; Triglycerides ; Ulcers ; Variables ; Vascular diseases</subject><ispartof>Disease markers, 2020, Vol.2020 (2020), p.1-10</ispartof><rights>Copyright © 2020 Caroline Conceição da Guarda et al.</rights><rights>COPYRIGHT 2020 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2020 Caroline Conceição da Guarda et al. 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Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. 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complications</topic><topic>Anemia, Sickle Cell - metabolism</topic><topic>Antilipemic agents</topic><topic>Atherosclerosis</topic><topic>Bacterial pneumonia</topic><topic>Blood</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Cholesterol - analysis</topic><topic>Cholesterol, HDL - analysis</topic><topic>Cholesterol, LDL - analysis</topic><topic>Complications</topic><topic>Cross-Sectional Studies</topic><topic>Density</topic><topic>Female</topic><topic>Guardians</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Hemolysis</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Investigations</topic><topic>Laboratories</topic><topic>Leg ulcers</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Metabolites</topic><topic>Pain</topic><topic>Parameters</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Phenotypes</topic><topic>Pneumonia</topic><topic>Pulmonary hypertension</topic><topic>Severity of Illness Index</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><topic>Software</topic><topic>Triglycerides</topic><topic>Ulcers</topic><topic>Variables</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fonseca, Cleverson Alves</creatorcontrib><creatorcontrib>Carvalho, Suellen Pinheiro</creatorcontrib><creatorcontrib>de Oliveira, Rodrigo Mota</creatorcontrib><creatorcontrib>Nascimento, Valma Maria Lopes</creatorcontrib><creatorcontrib>Rocha, Larissa Carneiro</creatorcontrib><creatorcontrib>Gonçalves, Marilda Souza</creatorcontrib><creatorcontrib>Figueiredo, Camylla Vilas Boas</creatorcontrib><creatorcontrib>Aleluia, Milena Magalhães</creatorcontrib><creatorcontrib>Oliveira, Antonio Mateus de Jesus</creatorcontrib><creatorcontrib>Neres, Joelma Santana dos Santos</creatorcontrib><creatorcontrib>Fernandes, Camila Felix de Lima</creatorcontrib><creatorcontrib>Santiago, Rayra Pereira</creatorcontrib><creatorcontrib>Yahouédéhou, Sètondji Cocou Modeste Alexandre</creatorcontrib><creatorcontrib>da Guarda, Caroline Conceição</creatorcontrib><creatorcontrib>Fiuza, Luciana Magalhães</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension. We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients. Methods. Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy. Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated. Results. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels. Decreased LDL-C levels were also associated with leg ulcers and anemia. Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis. Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings. Conclusions. In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32884585</pmid><doi>10.1155/2020/8842362</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3000-1437</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Anemia
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - metabolism
Antilipemic agents
Atherosclerosis
Bacterial pneumonia
Blood
Care and treatment
Cholesterol
Cholesterol - analysis
Cholesterol, HDL - analysis
Cholesterol, LDL - analysis
Complications
Cross-Sectional Studies
Density
Female
Guardians
Hematology
Hemoglobin
Hemolysis
High density lipoprotein
Humans
Hypertension
Investigations
Laboratories
Leg ulcers
Lipids
Lipoproteins
Low density lipoprotein
Low density lipoproteins
Male
Metabolites
Pain
Parameters
Patients
Pediatrics
Phenotypes
Pneumonia
Pulmonary hypertension
Severity of Illness Index
Sickle cell anemia
Sickle cell disease
Software
Triglycerides
Ulcers
Variables
Vascular diseases
title Investigation of Lipid Profile and Clinical Manifestations in SCA Children
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