Selenium detoxification is required for cancer-cell survival

The micronutrient selenium is incorporated via the selenocysteine biosynthesis pathway into the rare amino acid selenocysteine, which is required in selenoproteins such as glutathione peroxidases and thioredoxin reductases 1 , 2 . Here, we show that selenophosphate synthetase 2 (SEPHS2), an enzyme i...

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Veröffentlicht in:	Nature metabolism 2020-07, Vol.2 (7), p.603-611
Hauptverfasser:	Carlisle, Anne E., Lee, Namgyu, Matthew-Onabanjo, Asia N., Spears, Meghan E., Park, Sung Jin, Youkana, Daniel, Doshi, Mihir B., Peppers, Austin, Li, Rui, Joseph, Alexander B., Smith, Miles, Simin, Karl, Zhu, Lihua Julie, Greer, Paul L., Shaw, Leslie M., Kim, Dohoon
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 13/31 13/51 14 14/19 14/63 42/41 45 45/44 45/70 631/67/1059 631/67/2327 64/60 82 82/29 82/80 Amino Acid Transport System y+ - metabolism Animals Biomedical and Life Sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Survival Female Ferroptosis Humans Inactivation, Metabolic Letter Life Sciences Mice Mice, Nude Neoplasms - metabolism Neoplasms - pathology Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Phosphotransferases - metabolism Selenium - metabolism Selenium Compounds - metabolism Selenocysteine - metabolism Xenograft Model Antitumor Assays
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