Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques
Abstract Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial...
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| Veröffentlicht in: | The Journal of infectious diseases 2020-11, Vol.222 (10), p.1596-1600 |
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| container_title | The Journal of infectious diseases |
| container_volume | 222 |
| creator | Koo, Bon-Sang Oh, Hanseul Kim, Green Hwang, Eun-Ha Jung, Hoyin Lee, Youngjeon Kang, Philyong Park, Jae-Hak Ryu, Choong-Min Hong, Jung Joo |
| description | Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies. |
| doi_str_mv | 10.1093/infdis/jiaa486 |
| format | Article |
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Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa486</identifier><identifier>PMID: 32745172</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Animals ; Betacoronavirus - genetics ; Coronaviridae ; Coronavirus Infections - complications ; Coronavirus Infections - pathology ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Disease Models, Animal ; Disease transmission ; Female ; Immune system ; Lung Diseases, Interstitial - complications ; Lung Diseases, Interstitial - pathology ; Lymphocytes ; Lymphopenia ; Lymphopenia - complications ; Lymphopenia - pathology ; Macaca fascicularis ; Macaca mulatta ; Major and Brief Reports ; Male ; Monkey Diseases - pathology ; Monkey Diseases - virology ; Pandemics ; Pneumonia ; Pneumonia, Viral - complications ; Pneumonia, Viral - pathology ; Pneumonia, Viral - virology ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2</subject><ispartof>The Journal of infectious diseases, 2020-11, Vol.222 (10), p.1596-1600</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-cbcd78cd615ee352a7d9fe43d91aeb9a6d871ffa64125b26c70bfcfccf9c2bf93</citedby><cites>FETCH-LOGICAL-c452t-cbcd78cd615ee352a7d9fe43d91aeb9a6d871ffa64125b26c70bfcfccf9c2bf93</cites><orcidid>0000-0002-9795-6513</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32745172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koo, Bon-Sang</creatorcontrib><creatorcontrib>Oh, Hanseul</creatorcontrib><creatorcontrib>Kim, Green</creatorcontrib><creatorcontrib>Hwang, Eun-Ha</creatorcontrib><creatorcontrib>Jung, Hoyin</creatorcontrib><creatorcontrib>Lee, Youngjeon</creatorcontrib><creatorcontrib>Kang, Philyong</creatorcontrib><creatorcontrib>Park, Jae-Hak</creatorcontrib><creatorcontrib>Ryu, Choong-Min</creatorcontrib><creatorcontrib>Hong, Jung Joo</creatorcontrib><title>Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.</description><subject>Animals</subject><subject>Betacoronavirus - genetics</subject><subject>Coronaviridae</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - pathology</subject><subject>Coronavirus Infections - virology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Disease Models, Animal</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Immune system</subject><subject>Lung Diseases, Interstitial - complications</subject><subject>Lung Diseases, Interstitial - pathology</subject><subject>Lymphocytes</subject><subject>Lymphopenia</subject><subject>Lymphopenia - complications</subject><subject>Lymphopenia - pathology</subject><subject>Macaca fascicularis</subject><subject>Macaca mulatta</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Monkey Diseases - pathology</subject><subject>Monkey Diseases - virology</subject><subject>Pandemics</subject><subject>Pneumonia</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - pathology</subject><subject>Pneumonia, Viral - virology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokNhyxJFYgOLtP6LHW-QqlGBkaYC0QJLy_EP41Fip3aC1B3vwBv2SerRDBVlw-ouzneP7rkHgJcIniAoyKkPzvh8uvVK0ZY9AgvUEF4zhshjsIAQ4xq1QhyBZzlvIYSUMP4UHBHMaYM4XgB7lVTI3oapWt8M4yaONnhVqWCqVZhsypOfvOqrz8HOQ9xJ3_20qc6DidPG9r6oufKhujz7clkv47ca3_76vQrO6sma6kJpdT3b_Bw8carP9sVhHoOv78-vlh_r9acPq-XZuta0wVOtO214qw1DjbWkwYob4SwlRiBlO6GYaTlyTjGKcNNhpjnsnHZaO6Fx5wQ5Bu_2vuPcDdboEiupXo7JDyrdyKi8fKgEv5E_4k9Z3kGZIMXgzcEgxd3hkxx81rbvVbBxzhJTAgmnWPCCvv4H3cY5hRKvUJy1HFLcFupkT-kUc07W3R-DoNw1KPcNykODZeHV3xHu8T-VFeDtHojz-D-zO5zxq3E</recordid><startdate>20201115</startdate><enddate>20201115</enddate><creator>Koo, Bon-Sang</creator><creator>Oh, Hanseul</creator><creator>Kim, Green</creator><creator>Hwang, Eun-Ha</creator><creator>Jung, Hoyin</creator><creator>Lee, Youngjeon</creator><creator>Kang, Philyong</creator><creator>Park, Jae-Hak</creator><creator>Ryu, Choong-Min</creator><creator>Hong, Jung Joo</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9795-6513</orcidid></search><sort><creationdate>20201115</creationdate><title>Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques</title><author>Koo, Bon-Sang ; Oh, Hanseul ; Kim, Green ; Hwang, Eun-Ha ; Jung, Hoyin ; Lee, Youngjeon ; Kang, Philyong ; Park, Jae-Hak ; Ryu, Choong-Min ; Hong, Jung Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-cbcd78cd615ee352a7d9fe43d91aeb9a6d871ffa64125b26c70bfcfccf9c2bf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Betacoronavirus - genetics</topic><topic>Coronaviridae</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - pathology</topic><topic>Coronavirus Infections - virology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Disease Models, Animal</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Immune system</topic><topic>Lung Diseases, Interstitial - complications</topic><topic>Lung Diseases, Interstitial - pathology</topic><topic>Lymphocytes</topic><topic>Lymphopenia</topic><topic>Lymphopenia - complications</topic><topic>Lymphopenia - pathology</topic><topic>Macaca fascicularis</topic><topic>Macaca mulatta</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Monkey Diseases - pathology</topic><topic>Monkey Diseases - virology</topic><topic>Pandemics</topic><topic>Pneumonia</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - pathology</topic><topic>Pneumonia, Viral - virology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koo, Bon-Sang</creatorcontrib><creatorcontrib>Oh, Hanseul</creatorcontrib><creatorcontrib>Kim, Green</creatorcontrib><creatorcontrib>Hwang, Eun-Ha</creatorcontrib><creatorcontrib>Jung, Hoyin</creatorcontrib><creatorcontrib>Lee, Youngjeon</creatorcontrib><creatorcontrib>Kang, Philyong</creatorcontrib><creatorcontrib>Park, Jae-Hak</creatorcontrib><creatorcontrib>Ryu, Choong-Min</creatorcontrib><creatorcontrib>Hong, Jung Joo</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koo, Bon-Sang</au><au>Oh, Hanseul</au><au>Kim, Green</au><au>Hwang, Eun-Ha</au><au>Jung, Hoyin</au><au>Lee, Youngjeon</au><au>Kang, Philyong</au><au>Park, Jae-Hak</au><au>Ryu, Choong-Min</au><au>Hong, Jung Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2020-11-15</date><risdate>2020</risdate><volume>222</volume><issue>10</issue><spage>1596</spage><epage>1600</epage><pages>1596-1600</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32745172</pmid><doi>10.1093/infdis/jiaa486</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9795-6513</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Betacoronavirus - genetics Coronaviridae Coronavirus Infections - complications Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Disease Models, Animal Disease transmission Female Immune system Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - pathology Lymphocytes Lymphopenia Lymphopenia - complications Lymphopenia - pathology Macaca fascicularis Macaca mulatta Major and Brief Reports Male Monkey Diseases - pathology Monkey Diseases - virology Pandemics Pneumonia Pneumonia, Viral - complications Pneumonia, Viral - pathology Pneumonia, Viral - virology Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 |
| title | Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2–Infected Macaques |
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