Machine learning in drug development: Characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and uncertainty quantification

Prolonged QT intervals are a major risk factor for ventricular arrhythmias and a leading cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation and increase the proarrhythmic potential. Yet, how precisely the action of drugs on the cellular level translates into Q...

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Veröffentlicht in:Computer methods in applied mechanics and engineering 2019-05, Vol.348, p.313-333
Hauptverfasser: Sahli Costabal, Francisco, Matsuno, Kristen, Yao, Jiang, Perdikaris, Paris, Kuhl, Ellen
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Sprache:eng
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