A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response

Cancer is instigated by mutator phenotypes, including deficient mismatch repair and p53-associated chromosomal instability. More recently, a distinct class of cancers was identified with unusually high mutational loads due to heterozygous amino acid substitutions (most commonly P286R) in the proofre...

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Veröffentlicht in:	JCI insight 2020-07, Vol.5 (14)
Hauptverfasser:	Li, Hao-Dong, Lu, Changzheng, Zhang, He, Hu, Qing, Zhang, Junqiu, Cuevas, Ileana C, Sahoo, Subhransu S, Aguilar, Mitzi, Maurais, Elizabeth G, Zhang, Shanrong, Wang, Xiaojing, Akbay, Esra A, Li, Guo-Min, Li, Bo, Koduru, Prasad, Ly, Peter, Fu, Yang-Xin, Castrillon, Diego H
Format:	Artikel
Sprache:	eng
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