Baicalin alleviates collagen‑induced arthritis and suppresses TLR2/MYD88/NF‑κB p65 signaling in rats and HFLS‑RAs

Baicalin is a flavonoid isolated from the root of Scutellaria baicalensis with anti‑inflammatory, antioxidant and antiapoptotic pharmacological properties. however, the therapeutic effect of baicalin on rheumatoid arthritis (RA) is not completely understood. The present study aimed to explore the th...

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Veröffentlicht in:	Molecular medicine reports 2020-10, Vol.22 (4), p.2833-2841
Hauptverfasser:	Bai, Lin, Bai, Ya, Yang, Yuxin, Zhang, Wei, Huang, Ling, Ma, Rui, Wang, Li, Duan, Haizheng, Wan, Qiaofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Antioxidants Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - drug therapy Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Baicalin Cell Line Chemokines Collagen Collagen - adverse effects Cytokines Cytokines - blood Disease Models, Animal Fibroblasts Flavonoids Flavonoids - administration & dosage Gene expression Humans Hyperplasia Immunization Inflammation Joint diseases Kinases Male Manufacturers MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-κB protein Pathogenesis Pharmaceuticals Phytotherapy - methods Plant Extracts - administration & dosage Rats Rats, Sprague-Dawley Reverse transcription Rheumatoid arthritis Rodents Scutellaria baicalensis - chemistry Serum levels Signal transduction Signal Transduction - drug effects Synoviocytes Synoviocytes - drug effects Synoviocytes - metabolism TLR2 protein Toll-Like Receptor 2 - metabolism Toll-like receptors Transcription Factor RelA - metabolism Tumor necrosis factor-TNF Western blotting
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