Open and Closed Structures of a Barium-Blocked Potassium Channel

Barium (Ba2+) is a classic permeant blocker of potassium (K+) channels. The “external lock-in effect” in barium block experiments, whereby the binding of external K+ impedes the forward translocation of the blocker, provides a powerful avenue to investigate the selectivity of the binding sites along...

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Veröffentlicht in:	J. Mol. Biol 2020-08, Vol.432 (17), p.4783-4798
Hauptverfasser:	Rohaim, Ahmed, Gong, LiDong, Li, Jing, Rui, Huan, Blachowicz, Lydia, Roux, Benoît
Format:	Artikel
Sprache:	eng
Schlagworte:	Barium - chemistry Barium - pharmacology binding Binding Sites crystallography Crystallography, X-Ray free energy Models, Molecular molecular dynamics Molecular Dynamics Simulation polarization Potassium Channels - chemistry Potassium Channels - metabolism Protein Binding Protein Conformation
Online-Zugang:	Volltext
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