Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model
[Display omitted] •A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets.•In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow loop testing, and the valve showed trivial stenosis and trivial regurgi...
Gespeichert in:
| Veröffentlicht in: | JACC. Basic to translational science 2020-08, Vol.5 (8), p.815-828 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 828 |
|---|---|
| container_issue | 8 |
| container_start_page | 815 |
| container_title | JACC. Basic to translational science |
| container_volume | 5 |
| creator | Zakko, Jason Blum, Kevin M. Drews, Joseph D. Wu, Yen-Lin Hatoum, Hoda Russell, Madeleine Gooden, Shelley Heitkemper, Megan Conroy, Olivia Kelly, John Carey, Stacey Sacks, Michael Texter, Karen Ragsdale, Ellie Strainic, James Bocks, Martin Wang, Yadong Dasi, Lakshmi Prasad Armstrong, Aimee K. Breuer, Christopher |
| description | [Display omitted]
•A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets.•In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow loop testing, and the valve showed trivial stenosis and trivial regurgitation.•A large animal model was used for percutaneous delivery of the valve to the fetal pulmonary annulus.•Following implantation, the valve had no stenosis or regurgitation by echocardiography, and the fetal sheep matured and was delivered at term with the tissue-engineered valve.
This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart. |
| doi_str_mv | 10.1016/j.jacbts.2020.06.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7452327</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2452302X20302679</els_id><sourcerecordid>2439628210</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-b4b7ee79472d151878be3eed5eeb7c4ac304f71822b745001378b6783f7767bc3</originalsourceid><addsrcrecordid>eNp9kctKLDEQhoMoKuobuMjybKbNrTs9G-Hg5SgouhjFXUjS1Zoh0xmTdINvfyIjXjauqqCqvqq_foSOKakooc3Jslpqa3KqGGGkIk1FyHwL7TNRsxkn7Gn7W76HjlJaElLmuGzbehftcdbKmkq6j_w5TODDegVDxqHHC5fSCPhieHYDQIQOX4GOGT9qP0HCfYj4HqIdsx4gjAkvoh6S1fkFMkR8Dt5NEN-wG7DGl5C1x3dTIeHb0IE_RDu99gmOPuIBeri8WJxdzW7u_l2f_b2ZWSFInhlhJICcC8k6WtNWtgY4QFcDGGmFtpyIXtKWMSNFXXQVWaaRLe-lbKSx_ACdbrjr0aygs0Vb1F6to1vp-KaCdupnZXAv6jlMquAYZ7IA_nwAYngdIWW1csmC9xvVigk-b1jLKCmtYtNqY0gpQv-5hhL17pVaqo1X6t0rRRpVvPo6EcofJgdRJetgsNC5CDarLrjfAf8BCBafIw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2439628210</pqid></control><display><type>article</type><title>Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zakko, Jason ; Blum, Kevin M. ; Drews, Joseph D. ; Wu, Yen-Lin ; Hatoum, Hoda ; Russell, Madeleine ; Gooden, Shelley ; Heitkemper, Megan ; Conroy, Olivia ; Kelly, John ; Carey, Stacey ; Sacks, Michael ; Texter, Karen ; Ragsdale, Ellie ; Strainic, James ; Bocks, Martin ; Wang, Yadong ; Dasi, Lakshmi Prasad ; Armstrong, Aimee K. ; Breuer, Christopher</creator><creatorcontrib>Zakko, Jason ; Blum, Kevin M. ; Drews, Joseph D. ; Wu, Yen-Lin ; Hatoum, Hoda ; Russell, Madeleine ; Gooden, Shelley ; Heitkemper, Megan ; Conroy, Olivia ; Kelly, John ; Carey, Stacey ; Sacks, Michael ; Texter, Karen ; Ragsdale, Ellie ; Strainic, James ; Bocks, Martin ; Wang, Yadong ; Dasi, Lakshmi Prasad ; Armstrong, Aimee K. ; Breuer, Christopher</creatorcontrib><description>[Display omitted]
•A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets.•In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow loop testing, and the valve showed trivial stenosis and trivial regurgitation.•A large animal model was used for percutaneous delivery of the valve to the fetal pulmonary annulus.•Following implantation, the valve had no stenosis or regurgitation by echocardiography, and the fetal sheep matured and was delivered at term with the tissue-engineered valve.
This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart.</description><identifier>ISSN: 2452-302X</identifier><identifier>EISSN: 2452-302X</identifier><identifier>DOI: 10.1016/j.jacbts.2020.06.009</identifier><identifier>PMID: 32875171</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>congenital heart disease ; PRECLINICAL RESEARCH ; tissue-engineered heart valve ; transcatheter heart valve ; translational medicine</subject><ispartof>JACC. Basic to translational science, 2020-08, Vol.5 (8), p.815-828</ispartof><rights>2020 The Authors</rights><rights>2020 The Authors 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-b4b7ee79472d151878be3eed5eeb7c4ac304f71822b745001378b6783f7767bc3</citedby><cites>FETCH-LOGICAL-c440t-b4b7ee79472d151878be3eed5eeb7c4ac304f71822b745001378b6783f7767bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452327/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452327/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Zakko, Jason</creatorcontrib><creatorcontrib>Blum, Kevin M.</creatorcontrib><creatorcontrib>Drews, Joseph D.</creatorcontrib><creatorcontrib>Wu, Yen-Lin</creatorcontrib><creatorcontrib>Hatoum, Hoda</creatorcontrib><creatorcontrib>Russell, Madeleine</creatorcontrib><creatorcontrib>Gooden, Shelley</creatorcontrib><creatorcontrib>Heitkemper, Megan</creatorcontrib><creatorcontrib>Conroy, Olivia</creatorcontrib><creatorcontrib>Kelly, John</creatorcontrib><creatorcontrib>Carey, Stacey</creatorcontrib><creatorcontrib>Sacks, Michael</creatorcontrib><creatorcontrib>Texter, Karen</creatorcontrib><creatorcontrib>Ragsdale, Ellie</creatorcontrib><creatorcontrib>Strainic, James</creatorcontrib><creatorcontrib>Bocks, Martin</creatorcontrib><creatorcontrib>Wang, Yadong</creatorcontrib><creatorcontrib>Dasi, Lakshmi Prasad</creatorcontrib><creatorcontrib>Armstrong, Aimee K.</creatorcontrib><creatorcontrib>Breuer, Christopher</creatorcontrib><title>Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model</title><title>JACC. Basic to translational science</title><description>[Display omitted]
•A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets.•In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow loop testing, and the valve showed trivial stenosis and trivial regurgitation.•A large animal model was used for percutaneous delivery of the valve to the fetal pulmonary annulus.•Following implantation, the valve had no stenosis or regurgitation by echocardiography, and the fetal sheep matured and was delivered at term with the tissue-engineered valve.
This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart.</description><subject>congenital heart disease</subject><subject>PRECLINICAL RESEARCH</subject><subject>tissue-engineered heart valve</subject><subject>transcatheter heart valve</subject><subject>translational medicine</subject><issn>2452-302X</issn><issn>2452-302X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kctKLDEQhoMoKuobuMjybKbNrTs9G-Hg5SgouhjFXUjS1Zoh0xmTdINvfyIjXjauqqCqvqq_foSOKakooc3Jslpqa3KqGGGkIk1FyHwL7TNRsxkn7Gn7W76HjlJaElLmuGzbehftcdbKmkq6j_w5TODDegVDxqHHC5fSCPhieHYDQIQOX4GOGT9qP0HCfYj4HqIdsx4gjAkvoh6S1fkFMkR8Dt5NEN-wG7DGl5C1x3dTIeHb0IE_RDu99gmOPuIBeri8WJxdzW7u_l2f_b2ZWSFInhlhJICcC8k6WtNWtgY4QFcDGGmFtpyIXtKWMSNFXXQVWaaRLe-lbKSx_ACdbrjr0aygs0Vb1F6to1vp-KaCdupnZXAv6jlMquAYZ7IA_nwAYngdIWW1csmC9xvVigk-b1jLKCmtYtNqY0gpQv-5hhL17pVaqo1X6t0rRRpVvPo6EcofJgdRJetgsNC5CDarLrjfAf8BCBafIw</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Zakko, Jason</creator><creator>Blum, Kevin M.</creator><creator>Drews, Joseph D.</creator><creator>Wu, Yen-Lin</creator><creator>Hatoum, Hoda</creator><creator>Russell, Madeleine</creator><creator>Gooden, Shelley</creator><creator>Heitkemper, Megan</creator><creator>Conroy, Olivia</creator><creator>Kelly, John</creator><creator>Carey, Stacey</creator><creator>Sacks, Michael</creator><creator>Texter, Karen</creator><creator>Ragsdale, Ellie</creator><creator>Strainic, James</creator><creator>Bocks, Martin</creator><creator>Wang, Yadong</creator><creator>Dasi, Lakshmi Prasad</creator><creator>Armstrong, Aimee K.</creator><creator>Breuer, Christopher</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200801</creationdate><title>Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model</title><author>Zakko, Jason ; Blum, Kevin M. ; Drews, Joseph D. ; Wu, Yen-Lin ; Hatoum, Hoda ; Russell, Madeleine ; Gooden, Shelley ; Heitkemper, Megan ; Conroy, Olivia ; Kelly, John ; Carey, Stacey ; Sacks, Michael ; Texter, Karen ; Ragsdale, Ellie ; Strainic, James ; Bocks, Martin ; Wang, Yadong ; Dasi, Lakshmi Prasad ; Armstrong, Aimee K. ; Breuer, Christopher</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-b4b7ee79472d151878be3eed5eeb7c4ac304f71822b745001378b6783f7767bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>congenital heart disease</topic><topic>PRECLINICAL RESEARCH</topic><topic>tissue-engineered heart valve</topic><topic>transcatheter heart valve</topic><topic>translational medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zakko, Jason</creatorcontrib><creatorcontrib>Blum, Kevin M.</creatorcontrib><creatorcontrib>Drews, Joseph D.</creatorcontrib><creatorcontrib>Wu, Yen-Lin</creatorcontrib><creatorcontrib>Hatoum, Hoda</creatorcontrib><creatorcontrib>Russell, Madeleine</creatorcontrib><creatorcontrib>Gooden, Shelley</creatorcontrib><creatorcontrib>Heitkemper, Megan</creatorcontrib><creatorcontrib>Conroy, Olivia</creatorcontrib><creatorcontrib>Kelly, John</creatorcontrib><creatorcontrib>Carey, Stacey</creatorcontrib><creatorcontrib>Sacks, Michael</creatorcontrib><creatorcontrib>Texter, Karen</creatorcontrib><creatorcontrib>Ragsdale, Ellie</creatorcontrib><creatorcontrib>Strainic, James</creatorcontrib><creatorcontrib>Bocks, Martin</creatorcontrib><creatorcontrib>Wang, Yadong</creatorcontrib><creatorcontrib>Dasi, Lakshmi Prasad</creatorcontrib><creatorcontrib>Armstrong, Aimee K.</creatorcontrib><creatorcontrib>Breuer, Christopher</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JACC. Basic to translational science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zakko, Jason</au><au>Blum, Kevin M.</au><au>Drews, Joseph D.</au><au>Wu, Yen-Lin</au><au>Hatoum, Hoda</au><au>Russell, Madeleine</au><au>Gooden, Shelley</au><au>Heitkemper, Megan</au><au>Conroy, Olivia</au><au>Kelly, John</au><au>Carey, Stacey</au><au>Sacks, Michael</au><au>Texter, Karen</au><au>Ragsdale, Ellie</au><au>Strainic, James</au><au>Bocks, Martin</au><au>Wang, Yadong</au><au>Dasi, Lakshmi Prasad</au><au>Armstrong, Aimee K.</au><au>Breuer, Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model</atitle><jtitle>JACC. Basic to translational science</jtitle><date>2020-08-01</date><risdate>2020</risdate><volume>5</volume><issue>8</issue><spage>815</spage><epage>828</epage><pages>815-828</pages><issn>2452-302X</issn><eissn>2452-302X</eissn><abstract>[Display omitted]
•A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets.•In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow loop testing, and the valve showed trivial stenosis and trivial regurgitation.•A large animal model was used for percutaneous delivery of the valve to the fetal pulmonary annulus.•Following implantation, the valve had no stenosis or regurgitation by echocardiography, and the fetal sheep matured and was delivered at term with the tissue-engineered valve.
This multidisciplinary work shows the feasibility of replacing the fetal pulmonary valve with a percutaneous, transcatheter, fully biodegradable tissue-engineered heart valve (TEHV), which was studied in vitro through accelerated degradation, mechanical, and hemodynamic testing and in vivo by implantation into a fetal lamb. The TEHV exhibited only trivial stenosis and regurgitation in vitro and no stenosis in vivo by echocardiogram. Following implantation, the fetus matured and was delivered at term. Replacing a stenotic fetal valve with a functional TEHV has the potential to interrupt the development of single-ventricle heart disease by restoring proper flow through the heart.</abstract><pub>Elsevier Inc</pub><pmid>32875171</pmid><doi>10.1016/j.jacbts.2020.06.009</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2452-302X |
| ispartof | JACC. Basic to translational science, 2020-08, Vol.5 (8), p.815-828 |
| issn | 2452-302X 2452-302X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7452327 |
| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | congenital heart disease PRECLINICAL RESEARCH tissue-engineered heart valve transcatheter heart valve translational medicine |
| title | Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T04%3A41%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20Tissue%20Engineered%20Heart%20Valves%20for%20Percutaneous%20Transcatheter%20Delivery%20in%20a%20Fetal%20Ovine%20Model&rft.jtitle=JACC.%20Basic%20to%20translational%20science&rft.au=Zakko,%20Jason&rft.date=2020-08-01&rft.volume=5&rft.issue=8&rft.spage=815&rft.epage=828&rft.pages=815-828&rft.issn=2452-302X&rft.eissn=2452-302X&rft_id=info:doi/10.1016/j.jacbts.2020.06.009&rft_dat=%3Cproquest_pubme%3E2439628210%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2439628210&rft_id=info:pmid/32875171&rft_els_id=S2452302X20302679&rfr_iscdi=true |