Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency
[Display omitted] •Patients with CAD and renal insufficiency (eGFR
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| Veröffentlicht in: | JACC. Basic to translational science 2020-08, Vol.5 (8), p.770-782 |
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| creator | Mehta, Anurag Tahhan, Ayman S. Liu, Chang Dhindsa, Devinder S. Nayak, Aditi Hooda, Ananya Moazzami, Kasra Islam, Shabatun J. Rogers, Steven C. Almuwaqqat, Zakaria Mokhtari, Ali Hesaroieh, Iraj Ko, Yi-An Waller, Edmund K. Quyyumi, Arshed A. |
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•Patients with CAD and renal insufficiency (eGFR |
| doi_str_mv | 10.1016/j.jacbts.2020.06.006 |
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•Patients with CAD and renal insufficiency (eGFR <60 ml/min/1.73 m2) are at an increased risk of adverse outcomes.•CPC counts, an index of endogenous vascular regenerative capacity, may help stratify risk in patients with CAD and renal insufficiency.•Renal insufficiency is associated with lower CPC counts in old, but not young, patients with established CAD.•The increased risk of adverse outcomes with CAD and renal insufficiency is limited to patients with low, but not high, CPC counts.
Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 ml/min/1.73 m2) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell (CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45med+ mononuclear cells expressing CD34+, CD133+, CXCR4+ (chemokine [C-X-C motif] receptor 4), and VEGF2R+ (vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and low (<median) hematopoietic CPCs (CD34+, CD34+/CD133+, and CD34+/CXCR4+) were at an increased risk of cardiovascular death or myocardial infarction events (hazard ratios: 1.75 to 1.80) during 3.5-year follow-up, while those with RI and high CPCs (>median) were at a similar risk as those without RI.</description><identifier>ISSN: 2452-302X</identifier><identifier>EISSN: 2452-302X</identifier><identifier>DOI: 10.1016/j.jacbts.2020.06.006</identifier><identifier>PMID: 32875168</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>CLINICAL RESEARCH ; coronary artery disease ; outcomes ; progenitor cells ; regenerative capacity ; renal insufficiency</subject><ispartof>JACC. Basic to translational science, 2020-08, Vol.5 (8), p.770-782</ispartof><rights>2020 The Authors</rights><rights>2020 The Authors.</rights><rights>2020 The Authors 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-c169b9c3693b4696a42a354089268a6754d17b1beaa47f947348e50c4929b46d3</citedby><cites>FETCH-LOGICAL-c463t-c169b9c3693b4696a42a354089268a6754d17b1beaa47f947348e50c4929b46d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452291/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452291/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32875168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, Anurag</creatorcontrib><creatorcontrib>Tahhan, Ayman S.</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Dhindsa, Devinder S.</creatorcontrib><creatorcontrib>Nayak, Aditi</creatorcontrib><creatorcontrib>Hooda, Ananya</creatorcontrib><creatorcontrib>Moazzami, Kasra</creatorcontrib><creatorcontrib>Islam, Shabatun J.</creatorcontrib><creatorcontrib>Rogers, Steven C.</creatorcontrib><creatorcontrib>Almuwaqqat, Zakaria</creatorcontrib><creatorcontrib>Mokhtari, Ali</creatorcontrib><creatorcontrib>Hesaroieh, Iraj</creatorcontrib><creatorcontrib>Ko, Yi-An</creatorcontrib><creatorcontrib>Waller, Edmund K.</creatorcontrib><creatorcontrib>Quyyumi, Arshed A.</creatorcontrib><title>Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency</title><title>JACC. Basic to translational science</title><addtitle>JACC Basic Transl Sci</addtitle><description>[Display omitted]
•Patients with CAD and renal insufficiency (eGFR <60 ml/min/1.73 m2) are at an increased risk of adverse outcomes.•CPC counts, an index of endogenous vascular regenerative capacity, may help stratify risk in patients with CAD and renal insufficiency.•Renal insufficiency is associated with lower CPC counts in old, but not young, patients with established CAD.•The increased risk of adverse outcomes with CAD and renal insufficiency is limited to patients with low, but not high, CPC counts.
Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 ml/min/1.73 m2) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell (CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45med+ mononuclear cells expressing CD34+, CD133+, CXCR4+ (chemokine [C-X-C motif] receptor 4), and VEGF2R+ (vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and low (<median) hematopoietic CPCs (CD34+, CD34+/CD133+, and CD34+/CXCR4+) were at an increased risk of cardiovascular death or myocardial infarction events (hazard ratios: 1.75 to 1.80) during 3.5-year follow-up, while those with RI and high CPCs (>median) were at a similar risk as those without RI.</description><subject>CLINICAL RESEARCH</subject><subject>coronary artery disease</subject><subject>outcomes</subject><subject>progenitor cells</subject><subject>regenerative capacity</subject><subject>renal insufficiency</subject><issn>2452-302X</issn><issn>2452-302X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UV1LHTEQDaJUUf9BkTz25W7ztdnNS0FW2wpCRZT2qSGbnb3msjfRJCv4b_pb-ssae63VF59mYOacOXMOQu8pqSih8uOqWhnb51QxwkhFZEWI3EJ7TNRswQn7sf2i30WHKa0IKTjetG39Du1y1jY1le0e-tm5aOfJZOeX-CKGJXiXQ8QdTFPCzuOLMgKf0-9f312-wV2IwZv4gI9jhlJOXAKTABs_4EvwZsJnPs3j6GxB2YcDtDOaKcHhU91H159Pr7qvi_NvX8664_OFFZLnhaVS9cpyqXgvpJJGMMNrQVrFZGtkU4uBNj3twRjRjEo0XLRQEysUUwUw8H30acN7O_drGGxRHM2kb6NbF7E6GKdfT7y70ctwr5viElO0EHx4IojhboaU9dolW0wwHsKcNBNcSdaShpdVsVm1MaQUYXw-Q4l-TEev9CYd_ZiOJlKXdArs6KXEZ9C_LP7_AMWoewdRp78mwuAi2KyH4N6-8Ad9-qQ6</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Mehta, Anurag</creator><creator>Tahhan, Ayman S.</creator><creator>Liu, Chang</creator><creator>Dhindsa, Devinder S.</creator><creator>Nayak, Aditi</creator><creator>Hooda, Ananya</creator><creator>Moazzami, Kasra</creator><creator>Islam, Shabatun J.</creator><creator>Rogers, Steven C.</creator><creator>Almuwaqqat, Zakaria</creator><creator>Mokhtari, Ali</creator><creator>Hesaroieh, Iraj</creator><creator>Ko, Yi-An</creator><creator>Waller, Edmund K.</creator><creator>Quyyumi, Arshed A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200801</creationdate><title>Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency</title><author>Mehta, Anurag ; Tahhan, Ayman S. ; Liu, Chang ; Dhindsa, Devinder S. ; Nayak, Aditi ; Hooda, Ananya ; Moazzami, Kasra ; Islam, Shabatun J. ; Rogers, Steven C. ; Almuwaqqat, Zakaria ; Mokhtari, Ali ; Hesaroieh, Iraj ; Ko, Yi-An ; Waller, Edmund K. ; Quyyumi, Arshed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-c169b9c3693b4696a42a354089268a6754d17b1beaa47f947348e50c4929b46d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CLINICAL RESEARCH</topic><topic>coronary artery disease</topic><topic>outcomes</topic><topic>progenitor cells</topic><topic>regenerative capacity</topic><topic>renal insufficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehta, Anurag</creatorcontrib><creatorcontrib>Tahhan, Ayman S.</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><creatorcontrib>Dhindsa, Devinder S.</creatorcontrib><creatorcontrib>Nayak, Aditi</creatorcontrib><creatorcontrib>Hooda, Ananya</creatorcontrib><creatorcontrib>Moazzami, Kasra</creatorcontrib><creatorcontrib>Islam, Shabatun J.</creatorcontrib><creatorcontrib>Rogers, Steven C.</creatorcontrib><creatorcontrib>Almuwaqqat, Zakaria</creatorcontrib><creatorcontrib>Mokhtari, Ali</creatorcontrib><creatorcontrib>Hesaroieh, Iraj</creatorcontrib><creatorcontrib>Ko, Yi-An</creatorcontrib><creatorcontrib>Waller, Edmund K.</creatorcontrib><creatorcontrib>Quyyumi, Arshed A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JACC. Basic to translational science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehta, Anurag</au><au>Tahhan, Ayman S.</au><au>Liu, Chang</au><au>Dhindsa, Devinder S.</au><au>Nayak, Aditi</au><au>Hooda, Ananya</au><au>Moazzami, Kasra</au><au>Islam, Shabatun J.</au><au>Rogers, Steven C.</au><au>Almuwaqqat, Zakaria</au><au>Mokhtari, Ali</au><au>Hesaroieh, Iraj</au><au>Ko, Yi-An</au><au>Waller, Edmund K.</au><au>Quyyumi, Arshed A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency</atitle><jtitle>JACC. Basic to translational science</jtitle><addtitle>JACC Basic Transl Sci</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>5</volume><issue>8</issue><spage>770</spage><epage>782</epage><pages>770-782</pages><issn>2452-302X</issn><eissn>2452-302X</eissn><abstract>[Display omitted]
•Patients with CAD and renal insufficiency (eGFR <60 ml/min/1.73 m2) are at an increased risk of adverse outcomes.•CPC counts, an index of endogenous vascular regenerative capacity, may help stratify risk in patients with CAD and renal insufficiency.•Renal insufficiency is associated with lower CPC counts in old, but not young, patients with established CAD.•The increased risk of adverse outcomes with CAD and renal insufficiency is limited to patients with low, but not high, CPC counts.
Patients with coronary artery disease and renal insufficiency (RI) (estimated glomerular filtration rate <60 ml/min/1.73 m2) are at an increased risk of cardiovascular events. The contribution of regenerative capacity, measured as circulating progenitor cell (CPC) counts, to this increased risk is unclear. CPCs were enumerated as cluster of differentiation (CD) 45med+ mononuclear cells expressing CD34+, CD133+, CXCR4+ (chemokine [C-X-C motif] receptor 4), and VEGF2R+ (vascular endothelial growth factor receptor 2) epitopes in 1,281 subjects with coronary artery disease (35% with RI). Patients with RI and low (<median) hematopoietic CPCs (CD34+, CD34+/CD133+, and CD34+/CXCR4+) were at an increased risk of cardiovascular death or myocardial infarction events (hazard ratios: 1.75 to 1.80) during 3.5-year follow-up, while those with RI and high CPCs (>median) were at a similar risk as those without RI.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32875168</pmid><doi>10.1016/j.jacbts.2020.06.006</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | CLINICAL RESEARCH coronary artery disease outcomes progenitor cells regenerative capacity renal insufficiency |
| title | Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency |
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