Thermostable small-molecule inhibitor of angiogenesis and vascular permeability that suppresses a pERK-FosB/ΔFosB-VCAM-1 axis

Vascular permeability and angiogenesis underpin neovascular age-related macular degeneration and diabetic retinopathy. While anti-VEGF therapies are widely used clinically, many patients do not respond optimally, or at all, and small-molecule therapies are lacking. Here, we identified a dibenzoxazep...

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Veröffentlicht in:	Science advances 2020-07, Vol.6 (31), p.eaaz7815
Hauptverfasser:	Li, Yue, Alhendi, Ahmad M N, Yeh, Mei-Chun, Elahy, Mina, Santiago, Fernando S, Deshpande, Nandan P, Wu, Ben, Chan, Enoch, Inam, Shafqat, Prado-Lourenco, Leonel, Marchand, Jessica, Joyce, Rohan D, Wilkinson-White, Lorna E, Raftery, Mark J, Zhu, Meidong, Adamson, Samuel J, Barnat, François, Viaud-Quentric, Karen, Sockler, Jim, Mackay, Joel P, Chang, Andrew, Mitchell, Paul, Marcuccio, Sebastian M, Khachigian, Levon M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Capillary Permeability Health and Medicine Humans Mice Molecular Biology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics Proto-Oncogene Proteins c-fos - metabolism Rabbits Rats SciAdv r-articles Vascular Cell Adhesion Molecule-1 - metabolism Vascular Cell Adhesion Molecule-1 - pharmacology Vascular Endothelial Growth Factor A - metabolism
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