Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients
Background. To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the p...
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| creator | Thang, Le Viet Quyet, Do Dung, Nguyen Huu Van My, Pham Loc, Nguyen Duc Van Khoa, Huynh Quyen, Dao Bui Quy Tuan, Pham Ngoc Huy Toan, Nguyen Duy |
| description | Background. To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the progression of AKI to CKD. Methods. A study of 121 consecutive adult patients admitted to the intensive care unit (ICU) diagnosed as SA-AKI. AKI and CKD were defined based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Glomerular filtration rate (GFR) was calculated by the CKD-EPI formula. Serum and urine NGAL was measured using the BioVendor Human Lipocalin-2/NGAL ELISA with a blood sample taken at hospital admission time. Results. The ratio of AKI to CKD in SA-AKI patients was 22.3%. Mean concentration of serum and urine NGAL in AKI to the CKD group was 790.99 ng/ml and 885.72 ng/ml, higher significantly than those of recovery patients (351.86 ng/ml and 264.68 ng/ml), p |
| doi_str_mv | 10.1155/2020/8883404 |
| format | Article |
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To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the progression of AKI to CKD. Methods. A study of 121 consecutive adult patients admitted to the intensive care unit (ICU) diagnosed as SA-AKI. AKI and CKD were defined based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Glomerular filtration rate (GFR) was calculated by the CKD-EPI formula. Serum and urine NGAL was measured using the BioVendor Human Lipocalin-2/NGAL ELISA with a blood sample taken at hospital admission time. Results. The ratio of AKI to CKD in SA-AKI patients was 22.3%. Mean concentration of serum and urine NGAL in AKI to the CKD group was 790.99 ng/ml and 885.72 ng/ml, higher significantly than those of recovery patients (351.86 ng/ml and 264.68 ng/ml), p<0.001. eGFR, both serum and urine NGAL had a predictive value for AKI to CKD (eGFR: AUC=0.857, Se=74.1%, Spe=92.6%, p<0.001. Serum NGAL: AUC=0.868, Se=77.8%, Spe=91.5%. Urine NGAL: AUC=0.869, Se=77.8%, Spe=92.6%, p<0.001. Conclusion. Serum and urine NGAL, measuring at hospital admission time, were good prognostic biomarkers of AKI to CKD in SA-AKI patients.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2020/8883404</identifier><identifier>PMID: 32908617</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acute Kidney Injury - complications ; Acute Kidney Injury - etiology ; Acute Kidney Injury - metabolism ; Acute Kidney Injury - physiopathology ; Adult ; Aged ; Aged, 80 and over ; Anuria ; Biomarkers ; Biomarkers - blood ; Biomarkers - urine ; Blood pressure ; Chronic kidney failure ; Creatinine ; Diabetes ; Disease Progression ; Dopamine ; Enzymes ; Epidermal growth factor receptors ; Female ; Gelatinase ; Glomerular Filtration Rate ; Hospitals ; Humans ; Hypertension ; Immunoassay ; Infection ; Injuries ; Intensive Care Units ; Kidney diseases ; Kidneys ; Laboratories ; Lipocalin ; Lipocalin-2 - blood ; Lipocalin-2 - urine ; Male ; Measurement ; Medical research ; Medicine, Experimental ; Middle Aged ; Mortality ; Neutrophils ; Oliguria ; Prospective Studies ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - etiology ; Renal Insufficiency, Chronic - metabolism ; Sepsis ; Sepsis - complications ; Urine</subject><ispartof>Disease markers, 2020, Vol.2020 (2020), p.1-8</ispartof><rights>Copyright © 2020 Pham Ngoc Huy Tuan et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Pham Ngoc Huy Tuan et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Pham Ngoc Huy Tuan et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-28920cb6cf7f9be88d3021f7fa1a716c9c0c18763dbfd7b7b2413fc09c5998c83</citedby><cites>FETCH-LOGICAL-c499t-28920cb6cf7f9be88d3021f7fa1a716c9c0c18763dbfd7b7b2413fc09c5998c83</cites><orcidid>0000-0002-2283-9988</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450319/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450319/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32908617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Theocharis, Stamatios E.</contributor><contributor>Stamatios E Theocharis</contributor><creatorcontrib>Thang, Le Viet</creatorcontrib><creatorcontrib>Quyet, Do</creatorcontrib><creatorcontrib>Dung, Nguyen Huu</creatorcontrib><creatorcontrib>Van My, Pham</creatorcontrib><creatorcontrib>Loc, Nguyen Duc</creatorcontrib><creatorcontrib>Van Khoa, Huynh</creatorcontrib><creatorcontrib>Quyen, Dao Bui Quy</creatorcontrib><creatorcontrib>Tuan, Pham Ngoc Huy</creatorcontrib><creatorcontrib>Toan, Nguyen Duy</creatorcontrib><title>Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Background. To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the progression of AKI to CKD. Methods. A study of 121 consecutive adult patients admitted to the intensive care unit (ICU) diagnosed as SA-AKI. AKI and CKD were defined based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Glomerular filtration rate (GFR) was calculated by the CKD-EPI formula. Serum and urine NGAL was measured using the BioVendor Human Lipocalin-2/NGAL ELISA with a blood sample taken at hospital admission time. Results. The ratio of AKI to CKD in SA-AKI patients was 22.3%. Mean concentration of serum and urine NGAL in AKI to the CKD group was 790.99 ng/ml and 885.72 ng/ml, higher significantly than those of recovery patients (351.86 ng/ml and 264.68 ng/ml), p<0.001. eGFR, both serum and urine NGAL had a predictive value for AKI to CKD (eGFR: AUC=0.857, Se=74.1%, Spe=92.6%, p<0.001. Serum NGAL: AUC=0.868, Se=77.8%, Spe=91.5%. Urine NGAL: AUC=0.869, Se=77.8%, Spe=92.6%, p<0.001. Conclusion. Serum and urine NGAL, measuring at hospital admission time, were good prognostic biomarkers of AKI to CKD in SA-AKI patients.</description><subject>Acute Kidney Injury - complications</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - metabolism</subject><subject>Acute Kidney Injury - physiopathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anuria</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Blood pressure</subject><subject>Chronic kidney failure</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Disease Progression</subject><subject>Dopamine</subject><subject>Enzymes</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Gelatinase</subject><subject>Glomerular Filtration Rate</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Immunoassay</subject><subject>Infection</subject><subject>Injuries</subject><subject>Intensive Care Units</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Lipocalin</subject><subject>Lipocalin-2 - blood</subject><subject>Lipocalin-2 - urine</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Oliguria</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency, Chronic - diagnosis</subject><subject>Renal Insufficiency, Chronic - etiology</subject><subject>Renal Insufficiency, Chronic - metabolism</subject><subject>Sepsis</subject><subject>Sepsis - complications</subject><subject>Urine</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkstuEzEUhi0EomlhxxpZYoMEQ32Zi72pNApQKgJUKl1bHs-ZxNHEDvZMqzwZr4ejSS-wYnXkcz7_56IfoVeUfKC0KE4ZYeRUCMFzkj9BMyqqIhMlJ0_RjLBKZITl5Agdx7gmhDKZy-foiDNJREmrGfp9BWHcYO1afB2sA_wdxiH47cr2-Bx6PVinI2R1jN5YPUCLF3brje6twwu4gT7ib6DjGFJFD7huNzZG6x2-TBlrhhT9MsCUGzyer4J31uCvtnWwwx9tTL8BJ7Ur2EYbH3eqzTjAHXnh1mPY4cs0EbghvkDPOt1HeHmIJ-j686ef8y_Z4sf5xbxeZCaXcsiYkIyYpjRd1ckGhGg5YTQ9NNUVLY00xKSLlbxturZqqobllHeGSFNIKYzgJ-hs0t2OzQZak3oH3attsBsddsprq_6uOLtSS3-jqrwgnMok8PYgEPyvEeKg0oUM9L124MeoWJ7TkkhZ7NE3_6BrPwaX1ksUF4WoJC0fqKXuQVnX-dTX7EVVXXLJKj5pvZ8oE3yMAbr7kSlRe9-ovW_UwTcJf_14zXv4zigJeDcBK-tafWv_Uw4SA51-oGmR03TuPxmf14U</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Thang, Le Viet</creator><creator>Quyet, Do</creator><creator>Dung, Nguyen Huu</creator><creator>Van My, Pham</creator><creator>Loc, Nguyen Duc</creator><creator>Van Khoa, Huynh</creator><creator>Quyen, Dao Bui Quy</creator><creator>Tuan, Pham Ngoc Huy</creator><creator>Toan, Nguyen Duy</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2283-9988</orcidid></search><sort><creationdate>2020</creationdate><title>Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients</title><author>Thang, Le Viet ; Quyet, Do ; Dung, Nguyen Huu ; Van My, Pham ; Loc, Nguyen Duc ; Van Khoa, Huynh ; Quyen, Dao Bui Quy ; Tuan, Pham Ngoc Huy ; Toan, Nguyen Duy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-28920cb6cf7f9be88d3021f7fa1a716c9c0c18763dbfd7b7b2413fc09c5998c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Kidney Injury - complications</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - metabolism</topic><topic>Acute Kidney Injury - physiopathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anuria</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Blood pressure</topic><topic>Chronic kidney failure</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Disease Progression</topic><topic>Dopamine</topic><topic>Enzymes</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Gelatinase</topic><topic>Glomerular Filtration Rate</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Immunoassay</topic><topic>Infection</topic><topic>Injuries</topic><topic>Intensive Care Units</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Laboratories</topic><topic>Lipocalin</topic><topic>Lipocalin-2 - blood</topic><topic>Lipocalin-2 - urine</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>Oliguria</topic><topic>Prospective Studies</topic><topic>Renal Insufficiency, Chronic - diagnosis</topic><topic>Renal Insufficiency, Chronic - etiology</topic><topic>Renal Insufficiency, Chronic - metabolism</topic><topic>Sepsis</topic><topic>Sepsis - complications</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thang, Le Viet</creatorcontrib><creatorcontrib>Quyet, Do</creatorcontrib><creatorcontrib>Dung, Nguyen Huu</creatorcontrib><creatorcontrib>Van My, Pham</creatorcontrib><creatorcontrib>Loc, Nguyen Duc</creatorcontrib><creatorcontrib>Van Khoa, Huynh</creatorcontrib><creatorcontrib>Quyen, Dao Bui Quy</creatorcontrib><creatorcontrib>Tuan, Pham Ngoc Huy</creatorcontrib><creatorcontrib>Toan, Nguyen Duy</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thang, Le Viet</au><au>Quyet, Do</au><au>Dung, Nguyen Huu</au><au>Van My, Pham</au><au>Loc, Nguyen Duc</au><au>Van Khoa, Huynh</au><au>Quyen, Dao Bui Quy</au><au>Tuan, Pham Ngoc Huy</au><au>Toan, Nguyen Duy</au><au>Theocharis, Stamatios E.</au><au>Stamatios E Theocharis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Background. To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the progression of AKI to CKD. Methods. A study of 121 consecutive adult patients admitted to the intensive care unit (ICU) diagnosed as SA-AKI. AKI and CKD were defined based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Glomerular filtration rate (GFR) was calculated by the CKD-EPI formula. Serum and urine NGAL was measured using the BioVendor Human Lipocalin-2/NGAL ELISA with a blood sample taken at hospital admission time. Results. The ratio of AKI to CKD in SA-AKI patients was 22.3%. Mean concentration of serum and urine NGAL in AKI to the CKD group was 790.99 ng/ml and 885.72 ng/ml, higher significantly than those of recovery patients (351.86 ng/ml and 264.68 ng/ml), p<0.001. eGFR, both serum and urine NGAL had a predictive value for AKI to CKD (eGFR: AUC=0.857, Se=74.1%, Spe=92.6%, p<0.001. Serum NGAL: AUC=0.868, Se=77.8%, Spe=91.5%. Urine NGAL: AUC=0.869, Se=77.8%, Spe=92.6%, p<0.001. Conclusion. Serum and urine NGAL, measuring at hospital admission time, were good prognostic biomarkers of AKI to CKD in SA-AKI patients.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32908617</pmid><doi>10.1155/2020/8883404</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2283-9988</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - complications Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Acute Kidney Injury - physiopathology Adult Aged Aged, 80 and over Anuria Biomarkers Biomarkers - blood Biomarkers - urine Blood pressure Chronic kidney failure Creatinine Diabetes Disease Progression Dopamine Enzymes Epidermal growth factor receptors Female Gelatinase Glomerular Filtration Rate Hospitals Humans Hypertension Immunoassay Infection Injuries Intensive Care Units Kidney diseases Kidneys Laboratories Lipocalin Lipocalin-2 - blood Lipocalin-2 - urine Male Measurement Medical research Medicine, Experimental Middle Aged Mortality Neutrophils Oliguria Prospective Studies Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - metabolism Sepsis Sepsis - complications Urine |
| title | Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients |
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