SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged the speed at which laboratories can discover the viral composition and study health outcomes. The small ∼30-kb ssRNA genome of coronaviruses makes them adept at cross-species spread while enabling a ro...

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Veröffentlicht in:	The Journal of biological chemistry 2020-08, Vol.295 (33), p.11742-11753
Hauptverfasser:	Gupta, Ruchir, Charron, Jacob, Stenger, Cynthia L., Painter, Jared, Steward, Hunter, Cook, Taylor W., Faber, William, Frisch, Austin, Lind, Eric, Bauss, Jacob, Li, Xiaopeng, Sirpilla, Olivia, Soehnlen, Xavier, Underwood, Adam, Hinds, David, Morris, Michele, Lamb, Neil, Carcillo, Joseph A., Bupp, Caleb, Uhal, Bruce D., Rajasekaran, Surender, Prokop, Jeremy W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems, Neutral - chemistry Amino Acid Transport Systems, Neutral - genetics Amino Acid Transport Systems, Neutral - metabolism Angiotensin-Converting Enzyme 2 Betacoronavirus - chemistry Betacoronavirus - genetics Black or African American Black People - genetics Coronavirus Infections - metabolism Coronavirus Infections - virology Coronavirus Nucleocapsid Proteins COVID-19 Databases, Protein Genetic Predisposition to Disease Genetic Variation Genomics and Proteomics Host-Pathogen Interactions human genetics Humans Male molecular dynamics Molecular Dynamics Simulation molecular evolution Nucleocapsid Proteins - chemistry Nucleocapsid Proteins - metabolism Pandemics Peptidyl-Dipeptidase A - chemistry Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Phosphoproteins Pneumonia, Viral - metabolism Pneumonia, Viral - virology post-translational modification (PTM) Protein Interaction Maps Protein Processing, Post-Translational protein structure Proteome receptor structure-function RNA virus SARS-CoV-2 Sequence Homology, Amino Acid Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism severe acute respiratory coronavirus 2 (SARS-CoV-2) Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - metabolism virus entry
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