Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review
A 68-year-old man was followed up with chronic kidney disease. Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) patholo...
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| Veröffentlicht in: | International cancer conference journal 2020-10, Vol.9 (4), p.182-186 |
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| creator | Masago, Toshihiko Kobayakawa, Susumu Ohtani, Yuu Taniguchi, Kenjirou Naka, Takuji Kuroda, Naoto Takahashi, Chihiro Isoyama, Tadahiro Sejima, Takehiro |
| description | A 68-year-old man was followed up with chronic kidney disease. Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) pathologically. Hence, laparoscopic nephrectomy was performed. Fluorescence in situ hybridization analysis revealed a break-apart of the transcription factor E3 (TFE3) genes in the left tumor. After 2 months postoperatively, nivolumab and ipilimumab were administered thrice intravenously, considering the intermediate risk by the IMDC risk classification. However, pleural effusion occurred but was removed adequately. Lung metastasis decreased, but new metastasis occurred at the left iliopsoas muscle. Target therapy was performed with axitinib. Unfortunately, he died 6 months later postoperatively. These tumors commonly occur in children than in adults, and very rare in elderly patients. Xp11.2 translocation RCC in the elderly has a poorer prognosis than that in children. To date, no effective treatment for Xp11.2 translocation RCC has been established. |
| doi_str_mv | 10.1007/s13691-020-00430-6 |
| format | Article |
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Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) pathologically. Hence, laparoscopic nephrectomy was performed. Fluorescence in situ hybridization analysis revealed a break-apart of the transcription factor E3 (TFE3) genes in the left tumor. After 2 months postoperatively, nivolumab and ipilimumab were administered thrice intravenously, considering the intermediate risk by the IMDC risk classification. However, pleural effusion occurred but was removed adequately. Lung metastasis decreased, but new metastasis occurred at the left iliopsoas muscle. Target therapy was performed with axitinib. Unfortunately, he died 6 months later postoperatively. These tumors commonly occur in children than in adults, and very rare in elderly patients. Xp11.2 translocation RCC in the elderly has a poorer prognosis than that in children. To date, no effective treatment for Xp11.2 translocation RCC has been established.</description><identifier>ISSN: 2192-3183</identifier><identifier>EISSN: 2192-3183</identifier><identifier>DOI: 10.1007/s13691-020-00430-6</identifier><identifier>PMID: 32903928</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Biopsy ; Case Report ; Case reports ; Chemotherapy ; Fluorescence in situ hybridization ; Gene fusion ; Genes ; Hybridization analysis ; Immunotherapy ; Kidney cancer ; Kidney diseases ; Laparoscopy ; Literature reviews ; Lung cancer ; Lungs ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Nephrectomy ; Neutrophils ; Oncology ; Pediatrics ; Pleural effusion ; Renal cell carcinoma ; Sarcoma ; Surgical Oncology ; Tumors</subject><ispartof>International cancer conference journal, 2020-10, Vol.9 (4), p.182-186</ispartof><rights>The Japan Society of Clinical Oncology 2020</rights><rights>The Japan Society of Clinical Oncology 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-845707aee883dabd02e671dcc81ad8cd564d1b04a39af51a466e63f9af21f32e3</citedby><cites>FETCH-LOGICAL-c405t-845707aee883dabd02e671dcc81ad8cd564d1b04a39af51a466e63f9af21f32e3</cites><orcidid>0000-0001-7142-2858</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450002/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920012064?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21367,27901,27902,33721,33722,41464,42533,43781,51294,53766,53768</link.rule.ids></links><search><creatorcontrib>Masago, Toshihiko</creatorcontrib><creatorcontrib>Kobayakawa, Susumu</creatorcontrib><creatorcontrib>Ohtani, Yuu</creatorcontrib><creatorcontrib>Taniguchi, Kenjirou</creatorcontrib><creatorcontrib>Naka, Takuji</creatorcontrib><creatorcontrib>Kuroda, Naoto</creatorcontrib><creatorcontrib>Takahashi, Chihiro</creatorcontrib><creatorcontrib>Isoyama, Tadahiro</creatorcontrib><creatorcontrib>Sejima, Takehiro</creatorcontrib><title>Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review</title><title>International cancer conference journal</title><addtitle>Int Canc Conf J</addtitle><description>A 68-year-old man was followed up with chronic kidney disease. Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) pathologically. Hence, laparoscopic nephrectomy was performed. Fluorescence in situ hybridization analysis revealed a break-apart of the transcription factor E3 (TFE3) genes in the left tumor. After 2 months postoperatively, nivolumab and ipilimumab were administered thrice intravenously, considering the intermediate risk by the IMDC risk classification. However, pleural effusion occurred but was removed adequately. Lung metastasis decreased, but new metastasis occurred at the left iliopsoas muscle. Target therapy was performed with axitinib. Unfortunately, he died 6 months later postoperatively. These tumors commonly occur in children than in adults, and very rare in elderly patients. Xp11.2 translocation RCC in the elderly has a poorer prognosis than that in children. To date, no effective treatment for Xp11.2 translocation RCC has been established.</description><subject>Biopsy</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene fusion</subject><subject>Genes</subject><subject>Hybridization analysis</subject><subject>Immunotherapy</subject><subject>Kidney cancer</subject><subject>Kidney diseases</subject><subject>Laparoscopy</subject><subject>Literature reviews</subject><subject>Lung cancer</subject><subject>Lungs</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Nephrectomy</subject><subject>Neutrophils</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>Pleural effusion</subject><subject>Renal cell carcinoma</subject><subject>Sarcoma</subject><subject>Surgical Oncology</subject><subject>Tumors</subject><issn>2192-3183</issn><issn>2192-3183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU1LHTEYhUNpqWL9A10Fuulm7JuPycx0USiibUFwo-Au5Cbv3BuZm1yTjOK_b8Yrbe3CTT6fc0jOIeQjgxMG0H3JTKiBNcChAZACGvWGHHI28EawXrz9Z31AjnO-BaioHKBX78mB4AOIgfeH5O5mx9gJpyWZkKdoTfEx0ITBTNTiVAeTrA9xa-iDLxt6dX4m6BoD0nHOC-oDLRukODlM0-PXymes-l1MhZrg6OQLJlPmtJzee3z4QN6NZsp4_Dwfkevzs6vTn83F5Y9fp98vGiuhLU0v2w46g9j3wpmVA46qY87anhnXW9cq6dgKpBGDGVtmpFKoxFg3nI2Cozgi3_a-u3m1RWcx1D9Oepf81qRHHY3XL2-C3-h1vNedbJewqsHnZ4MU72bMRW99XjIxAeOcNZeSKRBcDhX99B96G-dUM6zUwAEYByUrxfeUTTHnhOOfxzDQS6l6X6quTemnUrWqIrEX5QqHNaa_1q-ofgNA3qOY</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Masago, Toshihiko</creator><creator>Kobayakawa, Susumu</creator><creator>Ohtani, Yuu</creator><creator>Taniguchi, Kenjirou</creator><creator>Naka, Takuji</creator><creator>Kuroda, Naoto</creator><creator>Takahashi, Chihiro</creator><creator>Isoyama, Tadahiro</creator><creator>Sejima, Takehiro</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7142-2858</orcidid></search><sort><creationdate>20201001</creationdate><title>Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review</title><author>Masago, Toshihiko ; Kobayakawa, Susumu ; Ohtani, Yuu ; Taniguchi, Kenjirou ; Naka, Takuji ; Kuroda, Naoto ; Takahashi, Chihiro ; Isoyama, Tadahiro ; Sejima, Takehiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-845707aee883dabd02e671dcc81ad8cd564d1b04a39af51a466e63f9af21f32e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biopsy</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene fusion</topic><topic>Genes</topic><topic>Hybridization analysis</topic><topic>Immunotherapy</topic><topic>Kidney cancer</topic><topic>Kidney diseases</topic><topic>Laparoscopy</topic><topic>Literature reviews</topic><topic>Lung cancer</topic><topic>Lungs</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Nephrectomy</topic><topic>Neutrophils</topic><topic>Oncology</topic><topic>Pediatrics</topic><topic>Pleural effusion</topic><topic>Renal cell carcinoma</topic><topic>Sarcoma</topic><topic>Surgical Oncology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masago, Toshihiko</creatorcontrib><creatorcontrib>Kobayakawa, Susumu</creatorcontrib><creatorcontrib>Ohtani, Yuu</creatorcontrib><creatorcontrib>Taniguchi, Kenjirou</creatorcontrib><creatorcontrib>Naka, Takuji</creatorcontrib><creatorcontrib>Kuroda, Naoto</creatorcontrib><creatorcontrib>Takahashi, Chihiro</creatorcontrib><creatorcontrib>Isoyama, Tadahiro</creatorcontrib><creatorcontrib>Sejima, Takehiro</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International cancer conference journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masago, Toshihiko</au><au>Kobayakawa, Susumu</au><au>Ohtani, Yuu</au><au>Taniguchi, Kenjirou</au><au>Naka, Takuji</au><au>Kuroda, Naoto</au><au>Takahashi, Chihiro</au><au>Isoyama, Tadahiro</au><au>Sejima, Takehiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review</atitle><jtitle>International cancer conference journal</jtitle><stitle>Int Canc Conf J</stitle><date>2020-10-01</date><risdate>2020</risdate><volume>9</volume><issue>4</issue><spage>182</spage><epage>186</epage><pages>182-186</pages><issn>2192-3183</issn><eissn>2192-3183</eissn><abstract>A 68-year-old man was followed up with chronic kidney disease. Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) pathologically. Hence, laparoscopic nephrectomy was performed. Fluorescence in situ hybridization analysis revealed a break-apart of the transcription factor E3 (TFE3) genes in the left tumor. After 2 months postoperatively, nivolumab and ipilimumab were administered thrice intravenously, considering the intermediate risk by the IMDC risk classification. However, pleural effusion occurred but was removed adequately. Lung metastasis decreased, but new metastasis occurred at the left iliopsoas muscle. Target therapy was performed with axitinib. Unfortunately, he died 6 months later postoperatively. These tumors commonly occur in children than in adults, and very rare in elderly patients. Xp11.2 translocation RCC in the elderly has a poorer prognosis than that in children. To date, no effective treatment for Xp11.2 translocation RCC has been established.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32903928</pmid><doi>10.1007/s13691-020-00430-6</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7142-2858</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biopsy Case Report Case reports Chemotherapy Fluorescence in situ hybridization Gene fusion Genes Hybridization analysis Immunotherapy Kidney cancer Kidney diseases Laparoscopy Literature reviews Lung cancer Lungs Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Nephrectomy Neutrophils Oncology Pediatrics Pleural effusion Renal cell carcinoma Sarcoma Surgical Oncology Tumors |
| title | Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review |
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