Characterization of Amikacin Drug Exposure and Nephrotoxicity in an Animal Model

Despite excellent activity, aminoglycosides are used conservatively to treat multidrug-resistant bacterial infections due to their associated nephrotoxicity. Aminoglycosides are known to accumulate in the kidneys, but the quantitative relationship between drug exposures and nephrotoxicity is not wel...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2020-08, Vol.64 (9)
Hauptverfasser:	Chan, Katrina, Ledesma, Kimberly R, Wang, Weiqun, Tam, Vincent H
Format:	Artikel
Sprache:	eng
Schlagworte:	Experimental Therapeutics
Online-Zugang:	Volltext
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