ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens

Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, cut off...

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Veröffentlicht in:	Emerging microbes & infections 2020-01, Vol.9 (1), p.1259-1268
Hauptverfasser:	Suo, Tao, Liu, Xinjin, Feng, Jiangpeng, Guo, Ming, Hu, Wenjia, Guo, Dong, Ullah, Hafiz, Yang, Yang, Zhang, Qiuhan, Wang, Xin, Sajid, Muhanmmad, Huang, Zhixiang, Deng, Liping, Chen, Tielong, Liu, Fang, Xu, Ke, Liu, Yuan, Zhang, Qi, Liu, Yingle, Xiong, Yong, Chen, Guozhong, Lan, Ke, Chen, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Betacoronavirus - genetics clinical detection Coronavirus Infections - diagnosis COVID-19 droplet digital PCR false negative False Negative Reactions Humans Limit of Detection Pandemics Pneumonia, Viral - diagnosis Real-Time Polymerase Chain Reaction - methods RNA, Viral - genetics RT-PCR SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral Load - methods
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