Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma
The aim of the present study was to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‑mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms. The uptake of DVDMS by U‑118 MG cells was detected by flow cytometry (FCM). A 630‑nm...
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| Veröffentlicht in: | Oncology reports 2020-10, Vol.44 (4), p.1596-1604 |
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| creator | An, Ya-Wen Liu, Han-Qing Zhou, Zi-Qian Wang, Jian-Chun Jiang, Guang-Yu Li, Zhi-Wen Wang, Feng Jin, Hong-Tao |
| description | The aim of the present study was to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‑mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms. The uptake of DVDMS by U‑118 MG cells was detected by flow cytometry (FCM). A 630‑nm semiconductor laser and 1‑MHz ultrasound were used to perform PDT and SDT, respectively. Cell proliferation and apoptosis were evaluated using the Cell Counting Kit‑8 assay, FCM and Hoechst 33258 staining, respectively. Western blot analysis was used to detect protein expression and phosphorylation levels. BALB/c nude mice were used to establish a xenograft model of U‑118 MG cells. DVDMS was injected intravenously and PDT and SDT were performed 24 h later. An in vivo imaging system was used to evaluate the fluorescence of DVDMS, to measure tumor sizes, and to evaluate the therapeutic effects. The uptake of DVDMS by U‑118 MG cells was optimal after 4 h. PDT and SDT following DVDMS injection significantly inhibited the proliferation and increased apoptosis of glioma cells in vitro (P |
| doi_str_mv | 10.3892/or.2020.7695 |
| format | Article |
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The uptake of DVDMS by U‑118 MG cells was detected by flow cytometry (FCM). A 630‑nm semiconductor laser and 1‑MHz ultrasound were used to perform PDT and SDT, respectively. Cell proliferation and apoptosis were evaluated using the Cell Counting Kit‑8 assay, FCM and Hoechst 33258 staining, respectively. Western blot analysis was used to detect protein expression and phosphorylation levels. BALB/c nude mice were used to establish a xenograft model of U‑118 MG cells. DVDMS was injected intravenously and PDT and SDT were performed 24 h later. An in vivo imaging system was used to evaluate the fluorescence of DVDMS, to measure tumor sizes, and to evaluate the therapeutic effects. The uptake of DVDMS by U‑118 MG cells was optimal after 4 h. PDT and SDT following DVDMS injection significantly inhibited the proliferation and increased apoptosis of glioma cells in vitro (P<0.05, P<0.01) respectively. In vivo, the fluorescence intensity of DVDMS was lower in the PDT and SDT groups compared with the DVDMS group, while tumor cell proliferation and weight were lower in the PDT and SDT groups than in the control group (P<0.05, P<0.01). However, there was no significant difference when laser, ultrasound or DVDMS were applied individually, compared with the control group. Hematoxylin and eosin staining suggested that both PDT and SDT induced significant apoptosis and vascular obstruction in cancer tissues. DVDMS‑mediated PDT and SDT inhibited the expression levels of proliferating cell nuclear antigen (PCNA) and Bcl‑xL, increased cleaved ‑caspase 3 levels, and decreased the protein phosphorylation of the PI3K/AKT/mTOR signaling pathway. Changes in the expression of PCNA, and Bcl‑xL and in the levels of cleaved‑caspase 3 were partly reversed by N‑acetyl‑L‑cysteine, a reactive oxygen species (ROS) scavenger. Similar results were obtained with FCM. DVDMS‑mediated PDT and SDT inhibited glioma cell proliferation and induced cell apoptosis in vitro and in vivo, potentially by increasing the generation of ROS and affecting protein expression and phosphorylation levels.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.2020.7695</identifier><identifier>PMID: 32945475</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Animals ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - radiation effects ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Proliferation - radiation effects ; Combined Modality Therapy ; Cysteine ; Flow Cytometry ; Glioma ; Glioma - pathology ; Glioma - therapy ; Gliomas ; Health aspects ; Humans ; Immunotherapy ; Laboratory animals ; Lasers ; Lasers, Semiconductor - therapeutic use ; Life sciences ; Mice ; Photochemotherapy ; Porphyrins - pharmacology ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Tumors ; Ultrasonic imaging ; Ultrasonic Therapy ; Xenograft Model Antitumor Assays</subject><ispartof>Oncology reports, 2020-10, Vol.44 (4), p.1596-1604</ispartof><rights>COPYRIGHT 2020 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © An et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-143b6822becaad81f6dbec364a1f47d4cce42d1ecbf926847a21c18ab4dcf13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32945475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Ya-Wen</creatorcontrib><creatorcontrib>Liu, Han-Qing</creatorcontrib><creatorcontrib>Zhou, Zi-Qian</creatorcontrib><creatorcontrib>Wang, Jian-Chun</creatorcontrib><creatorcontrib>Jiang, Guang-Yu</creatorcontrib><creatorcontrib>Li, Zhi-Wen</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Jin, Hong-Tao</creatorcontrib><title>Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>The aim of the present study was to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‑mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms. The uptake of DVDMS by U‑118 MG cells was detected by flow cytometry (FCM). A 630‑nm semiconductor laser and 1‑MHz ultrasound were used to perform PDT and SDT, respectively. Cell proliferation and apoptosis were evaluated using the Cell Counting Kit‑8 assay, FCM and Hoechst 33258 staining, respectively. Western blot analysis was used to detect protein expression and phosphorylation levels. BALB/c nude mice were used to establish a xenograft model of U‑118 MG cells. DVDMS was injected intravenously and PDT and SDT were performed 24 h later. An in vivo imaging system was used to evaluate the fluorescence of DVDMS, to measure tumor sizes, and to evaluate the therapeutic effects. The uptake of DVDMS by U‑118 MG cells was optimal after 4 h. PDT and SDT following DVDMS injection significantly inhibited the proliferation and increased apoptosis of glioma cells in vitro (P<0.05, P<0.01) respectively. In vivo, the fluorescence intensity of DVDMS was lower in the PDT and SDT groups compared with the DVDMS group, while tumor cell proliferation and weight were lower in the PDT and SDT groups than in the control group (P<0.05, P<0.01). However, there was no significant difference when laser, ultrasound or DVDMS were applied individually, compared with the control group. Hematoxylin and eosin staining suggested that both PDT and SDT induced significant apoptosis and vascular obstruction in cancer tissues. DVDMS‑mediated PDT and SDT inhibited the expression levels of proliferating cell nuclear antigen (PCNA) and Bcl‑xL, increased cleaved ‑caspase 3 levels, and decreased the protein phosphorylation of the PI3K/AKT/mTOR signaling pathway. Changes in the expression of PCNA, and Bcl‑xL and in the levels of cleaved‑caspase 3 were partly reversed by N‑acetyl‑L‑cysteine, a reactive oxygen species (ROS) scavenger. Similar results were obtained with FCM. DVDMS‑mediated PDT and SDT inhibited glioma cell proliferation and induced cell apoptosis in vitro and in vivo, potentially by increasing the generation of ROS and affecting protein expression and phosphorylation levels.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - radiation effects</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Proliferation - radiation effects</subject><subject>Combined Modality Therapy</subject><subject>Cysteine</subject><subject>Flow Cytometry</subject><subject>Glioma</subject><subject>Glioma - pathology</subject><subject>Glioma - therapy</subject><subject>Gliomas</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Laboratory animals</subject><subject>Lasers</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Life sciences</subject><subject>Mice</subject><subject>Photochemotherapy</subject><subject>Porphyrins - pharmacology</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic Therapy</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkk1r3DAQhk1padK0t56LoVByqLf6smRfAiGkTSGQQ3roTcj6WCvYGleyC9tfX5mk22wIEmgkPfMOM7xF8R6jDW1a8gXihiCCNoK39YviGIsWV4RR_DLHiOCK0vrnUfEmpTuEiEC8fV0cUdKymon6uFC3PsAEcep30YcygfHLWPpUqnKKMPrkw7ZMNiQ_-z82lg5iOfUwg9kFNXpdqmByVtjf595GNe3KLLYdPIzqbfHKqSHZdw_nSXH79fLHxVV1ffPt-8X5daVrjOYKM9rxhpDOaqVMgx03OaScKeyYMExry4jBVneuJbxhQhGscaM6ZrTD9KQ4u1edlm60RtswRzXIKfpRxZ0E5eXhT_C93MJvKRhrGGqywOmDQIRfi02zzM1rOwwqWFiSJIwxKgRDPKMfn6B3sMSQm1spTEje5D-1VYOVPjjIdfUqKs855TVDNRKZ2jxD5WVsniYE63x-P0j49Ciht2qY-wTDMnsI6RD8fA_qCClF6_bDwEiuzpEQ5eocuTon4x8eD3AP_7MK_Qt3ib_U</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>An, Ya-Wen</creator><creator>Liu, Han-Qing</creator><creator>Zhou, Zi-Qian</creator><creator>Wang, Jian-Chun</creator><creator>Jiang, Guang-Yu</creator><creator>Li, Zhi-Wen</creator><creator>Wang, Feng</creator><creator>Jin, Hong-Tao</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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drug effects</topic><topic>Apoptosis - radiation effects</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Proliferation - radiation effects</topic><topic>Combined Modality Therapy</topic><topic>Cysteine</topic><topic>Flow Cytometry</topic><topic>Glioma</topic><topic>Glioma - pathology</topic><topic>Glioma - therapy</topic><topic>Gliomas</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Laboratory animals</topic><topic>Lasers</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Life sciences</topic><topic>Mice</topic><topic>Photochemotherapy</topic><topic>Porphyrins - pharmacology</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic Therapy</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>online_resources</toplevel><creatorcontrib>An, Ya-Wen</creatorcontrib><creatorcontrib>Liu, Han-Qing</creatorcontrib><creatorcontrib>Zhou, Zi-Qian</creatorcontrib><creatorcontrib>Wang, Jian-Chun</creatorcontrib><creatorcontrib>Jiang, Guang-Yu</creatorcontrib><creatorcontrib>Li, Zhi-Wen</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Jin, Hong-Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Ya-Wen</au><au>Liu, Han-Qing</au><au>Zhou, Zi-Qian</au><au>Wang, Jian-Chun</au><au>Jiang, Guang-Yu</au><au>Li, Zhi-Wen</au><au>Wang, Feng</au><au>Jin, Hong-Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>44</volume><issue>4</issue><spage>1596</spage><epage>1604</epage><pages>1596-1604</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>The aim of the present study was to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‑mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms. The uptake of DVDMS by U‑118 MG cells was detected by flow cytometry (FCM). A 630‑nm semiconductor laser and 1‑MHz ultrasound were used to perform PDT and SDT, respectively. Cell proliferation and apoptosis were evaluated using the Cell Counting Kit‑8 assay, FCM and Hoechst 33258 staining, respectively. Western blot analysis was used to detect protein expression and phosphorylation levels. BALB/c nude mice were used to establish a xenograft model of U‑118 MG cells. DVDMS was injected intravenously and PDT and SDT were performed 24 h later. An in vivo imaging system was used to evaluate the fluorescence of DVDMS, to measure tumor sizes, and to evaluate the therapeutic effects. The uptake of DVDMS by U‑118 MG cells was optimal after 4 h. PDT and SDT following DVDMS injection significantly inhibited the proliferation and increased apoptosis of glioma cells in vitro (P<0.05, P<0.01) respectively. In vivo, the fluorescence intensity of DVDMS was lower in the PDT and SDT groups compared with the DVDMS group, while tumor cell proliferation and weight were lower in the PDT and SDT groups than in the control group (P<0.05, P<0.01). However, there was no significant difference when laser, ultrasound or DVDMS were applied individually, compared with the control group. Hematoxylin and eosin staining suggested that both PDT and SDT induced significant apoptosis and vascular obstruction in cancer tissues. DVDMS‑mediated PDT and SDT inhibited the expression levels of proliferating cell nuclear antigen (PCNA) and Bcl‑xL, increased cleaved ‑caspase 3 levels, and decreased the protein phosphorylation of the PI3K/AKT/mTOR signaling pathway. Changes in the expression of PCNA, and Bcl‑xL and in the levels of cleaved‑caspase 3 were partly reversed by N‑acetyl‑L‑cysteine, a reactive oxygen species (ROS) scavenger. Similar results were obtained with FCM. DVDMS‑mediated PDT and SDT inhibited glioma cell proliferation and induced cell apoptosis in vitro and in vivo, potentially by increasing the generation of ROS and affecting protein expression and phosphorylation levels.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>32945475</pmid><doi>10.3892/or.2020.7695</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - radiation effects Combined Modality Therapy Cysteine Flow Cytometry Glioma Glioma - pathology Glioma - therapy Gliomas Health aspects Humans Immunotherapy Laboratory animals Lasers Lasers, Semiconductor - therapeutic use Life sciences Mice Photochemotherapy Porphyrins - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Tumors Ultrasonic imaging Ultrasonic Therapy Xenograft Model Antitumor Assays |
| title | Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma |
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