Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes

Translational control targeting the initiation phase is central to the regulation of gene expression. Understanding all of its aspects requires substantial technological advancements. Here we modified yeast translation complex profile sequencing (TCP-seq), related to ribosome profiling, and adapted...

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Veröffentlicht in:	Molecular cell 2020-08, Vol.79 (4), p.546-560.e7
Hauptverfasser:	Wagner, Susan, Herrmannová, Anna, Hronová, Vladislava, Gunišová, Stanislava, Sen, Neelam D., Hannan, Ross D., Hinnebusch, Alan G., Shirokikh, Nikolay E., Preiss, Thomas, Valášek, Leoš Shivaya
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism ATF4 Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism co-translational assembly Codon, Initiator eIF2 eIF3 Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Eukaryotic Initiation Factor-3 - genetics Eukaryotic Initiation Factor-3 - metabolism GCN4 gene expression HEK293 Cells Humans mRNA Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Protein Biosynthesis Ribo-seq ribosome ribosome profiling Ribosome Subunits, Small, Eukaryotic - genetics Ribosome Subunits, Small, Eukaryotic - metabolism Ribosomes - genetics Ribosomes - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism TCP-seq translational control UTR
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