Exploiting the sequence diversity of TALE-like repeats to vary the strength of dTALE-promoter interactions

Abstract Designer transcription activator-like effectors (dTALEs) are programmable transcription factors used to regulate user-defined promoters. The TALE DNA-binding domain is a tandem series of amino acid repeats that each bind one DNA base. Each repeat is 33–35 amino acids long. A residue in the...

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Veröffentlicht in:	Synthetic biology (Oxford University Press) 2017-01, Vol.2 (1), p.ysx004-ysx004
Hauptverfasser:	de Lange, Orlando, Schandry, Niklas, Wunderlich, Markus, Berendzen, Kenneth Wayne, Lahaye, Thomas
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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