Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation

The transcriptional regulator YAP, which plays important roles in the development, regeneration, and tumorigenesis, is activated when released from inhibition by the Hippo kinase cascade. The regulatory mechanism of YAP in Hippo-low contexts is poorly understood. Here, we performed a genome-wide RNA...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-08, Vol.117 (33), p.19994-20003
Hauptverfasser:	Kim, Yong Joon, Jung, Eunji, Shin, Eunbie, Hong, Sin-Hyoung, Jeong, Hui Su, Hur, Gayeong, Jeong, Hye Yun, Lee, Seung-Hyo, Lee, Ji Eun, Kim, Gun-Hwa, Kim, Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Biological Sciences Cancer Cell Line, Tumor Coat Protein Complex I - genetics Coat Protein Complex I - metabolism Cytokines Depletion Disruption Endoplasmic reticulum Gene Expression Regulation, Neoplastic Gene regulation Genome Genomes Humans Inflammatory diseases Interference Kinases MAP Kinase Kinase 3 - genetics MAP Kinase Kinase 3 - metabolism Mice Neoplasms - genetics Neoplasms - metabolism Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Regeneration Regulatory mechanisms (biology) Ribonucleic acid RNA RNA Interference RNA-mediated interference Signal Transduction Transcription Transcription Factors - genetics Transcription Factors - metabolism Tumorigenesis Yes-associated protein
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