Retromer forms low order oligomers on supported lipid bilayers

Retromer orchestrates the selection and export of integral membrane proteins from the endosome via retrograde and plasma membrane recycling pathways. Long-standing hypotheses regarding the retromer sorting mechanism posit that oligomeric interactions between retromer and associated accessory factors...

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Veröffentlicht in:	The Journal of biological chemistry 2020-08, Vol.295 (34), p.12305-12316
Hauptverfasser:	Deatherage, Catherine L., Nikolaus, Joerg, Karatekin, Erdem, Burd, Christopher G.
Format:	Artikel
Sprache:	eng
Schlagworte:	biochemical reconstitution Cell Biology Humans Lipid Bilayers - chemistry membrane bilayer Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism oligomerization Phosphate-Binding Proteins - chemistry Phosphate-Binding Proteins - metabolism rab GTP-Binding Proteins - chemistry rab GTP-Binding Proteins - metabolism rab7 GTP-Binding Proteins retromer single particle analysis Sorting Nexins - chemistry Sorting Nexins - metabolism trafficking WASHC2C
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