Glioma-Induced Alterations in Neuronal Activity and Neurovascular Coupling during Disease Progression

Diffusely infiltrating gliomas are known to cause alterations in cortical function, vascular disruption, and seizures. These neurological complications present major clinical challenges, yet their underlying mechanisms and causal relationships to disease progression are poorly characterized. Here, w...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-04, Vol.31 (2), p.107500-107500, Article 107500
Hauptverfasser:	Montgomery, Mary Katherine, Kim, Sharon H., Dovas, Athanassios, Zhao, Hanzhi T., Goldberg, Alexander R., Xu, Weihao, Yagielski, Alexis J., Cambareri, Morgan K., Patel, Kripa B., Mela, Angeliki, Humala, Nelson, Thibodeaux, David N., Shaik, Mohammed A., Ma, Ying, Grinband, Jack, Chow, Daniel S., Schevon, Catherine, Canoll, Peter, Hillman, Elizabeth M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - physiopathology Cerebral Cortex - metabolism Disease Progression glioma Glioma - physiopathology Hemodynamics - physiology interictal discharges Male Mice Mice, Inbred C57BL Nerve Net - physiopathology Neurons - metabolism neurovascular coupling Neurovascular Coupling - physiology seizures Seizures - physiopathology wide field optical mapping
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