Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway

Background. It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying mechanisms are still unclear. The purpose of thi...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-15
Hauptverfasser:	Liu, Cun-Zhi, Fisher, Marc, Su, Xin-Tong, Wang, Xue-Rui, Huang, Jin, Lin, Li-Ting, Yang, Jing-Wen, Wang, Lu, Cao, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Acupuncture Points Acupuncture Therapy Animals Carotid arteries Cognition - drug effects Cytokines Dementia Dementia, Vascular - drug therapy Dementia, Vascular - genetics Dementia, Vascular - physiopathology Dementia, Vascular - therapy Experiments Gene expression Hippocampus - pathology Hippocampus - physiopathology Inflammation Inflammation - therapy Male Memory Microglia - drug effects Microglia - metabolism Microglia - pathology MicroRNAs MicroRNAs - metabolism Models, Biological Myeloid Differentiation Factor 88 - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-kappa B - metabolism Rats, Wistar Rodents Signal Transduction - drug effects Surgery Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - metabolism Tumor necrosis factor-TNF Veins & arteries
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