Dysregulation of the OGF–OGFr pathway correlates with elevated serum OGF and ocular surface complications in the diabetic rat

Diabetes often presents with ocular surface complications including dry eye, keratopathy, and altered sensitivity, along with systemic disorders. A common theme associated with corneal surface defects is decreased cellular proliferation. The opioid growth factor (OGF)–OGF receptor (OGFr) regulatory...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2020-09, Vol.245 (15), p.1414-1421
Hauptverfasser:	Zagon, Ian S, Sassani, Joseph W, Purushothaman, Indira, McLaughlin, Patricia J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - blood Analgesics, Opioid - metabolism Animals Blood Glucose - metabolism Body Weight Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - metabolism Epithelium, Corneal - pathology Eye - pathology Male Neprilysin - blood Original Research Rats, Sprague-Dawley Re-Epithelialization Receptors, Opioid - blood Receptors, Opioid - metabolism Time Factors
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