C57BL/6J substrain differences in response to high-fat diet intervention

C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift and environmental confounders such as microbiome differences. To address potential vendor/substrain specific effects, we c...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.14052, Article 14052
Hauptverfasser:	Siersbæk, Majken Storm, Ditzel, Nicholas, Hejbøl, Eva Kildall, Præstholm, Stine Marie, Markussen, Lasse Kruse, Avolio, Fabio, Li, Lingzi, Lehtonen, Lasse, Hansen, Axel Kornerup, Schrøder, Henrik Daa, Krych, Lukasz, Mandrup, Susanne, Langhorn, Louise, Bollen, Peter, Grøntved, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/334 631/443/319 692/163/2743 692/699/2743 692/699/317 Absorptiometry, Photon Acclimatization Adipose tissue Animal models Animals Body Weight Body weight gain Diabetes Diet Diet, High-Fat Drinking water Endocrinology Energy Genetic drift Genomics Glucose Glucose - administration & dosage High fat diet Histology Humanities and Social Sciences Insulin - blood Insulin resistance Liver Liver - metabolism Metabolism Mice Mice, Inbred C57BL Microbiomes Microbiota multidisciplinary Mutation Obesity Obesity - genetics Organ Size Pancreas Physiology Science Science (multidisciplinary) Species Specificity Spleen Triglycerides Triglycerides - metabolism Weight Gain
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