A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions

Cell-surface protein-protein interactions (PPIs) mediate cell-cell communication, recognition, and responses. We executed an interactome screen of 564 human cell-surface and secreted proteins, most of which are immunoglobulin superfamily (IgSF) proteins, using a high-throughput, automated ELISA-base...

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Veröffentlicht in:	Cell 2020-08, Vol.182 (4), p.1027-1043.e17
Hauptverfasser:	Wojtowicz, Woj M., Vielmetter, Jost, Fernandes, Ricardo A., Siepe, Dirk H., Eastman, Catharine L., Chisholm, Gregory B., Cox, Sarah, Klock, Heath, Anderson, Paul W., Rue, Sarah M., Miller, Jessica J., Glaser, Scott M., Bragstad, Melisa L., Vance, Julie, Lam, Annie W., Lesley, Scott A., Zinn, Kai, Garcia, K. Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	cell-surface DCC Receptor - chemistry DCC Receptor - metabolism human IgSF Humans interactome ligand Ligands network Phylogeny Protein Interaction Maps - physiology protein-protein interaction screen receptor Receptor-Like Protein Tyrosine Phosphatases, Class 2 - chemistry Receptor-Like Protein Tyrosine Phosphatases, Class 2 - metabolism Receptors, Cell Surface - chemistry Receptors, Cell Surface - classification Receptors, Cell Surface - metabolism Receptors, Interleukin-1 - chemistry Receptors, Interleukin-1 - metabolism Signaling Lymphocytic Activation Molecule Family - chemistry Signaling Lymphocytic Activation Molecule Family - metabolism Surface Plasmon Resonance
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