In vitro and in vivo characterization of CPP and transferrin modified liposomes encapsulating pDNA

The limitations imposed on brain therapy by the blood–brain barrier (BBB) have warranted the development of carriers that can overcome and deliver therapeutic agents into the brain. We strategically designed liposomal nanoparticles encasing plasmid DNA for efficient transfection and translocation ac...

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Veröffentlicht in:	Nanomedicine 2020-08, Vol.28, p.102225-102225, Article 102225
Hauptverfasser:	dos Santos Rodrigues, Bruna, Kanekiyo, Takahisa, Singh, Jagdish
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Brain Brain - metabolism Cell-Penetrating Peptides - chemistry Endothelial Cells - metabolism Female Liposome Liposomes - chemistry Male Mice PFVYLI Plasmids - chemistry R9F2 Rats Rats, Sprague-Dawley Transferrin Transferrin - chemistry
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