A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome

Endoplasmic reticulum (ER) stress-mediated cell death is an emerging target for human chronic disorders, including neurodegeneration and diabetes. However, there is currently no treatment for preventing ER stress-mediated cell death. Here, we show that mesencephalic astrocyte-derived neurotrophic fa...

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Veröffentlicht in:	Laboratory investigation 2020-09, Vol.100 (9), p.1197-1207
Hauptverfasser:	Mahadevan, Jana, Morikawa, Shuntaro, Yagi, Takuya, Abreu, Damien, Lu, Simin, Kanekura, Kohsuke, Brown, Cris M., Urano, Fumihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 38 42 42/89 631/80/82/23 692/699/2743/137/773 82 82/51 Animal models Animals Apoptosis Beta cells Cell culture Cell death Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cells, Cultured Degeneration Diabetes Diabetes mellitus Disorders Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects Gene therapy Health services Humans Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Laboratory Medicine Medical treatment Medicine Medicine & Public Health Mice, Transgenic Mortality Nerve Growth Factors - pharmacology Neurodegeneration Neurotrophic factors Pathology Prototypes Rats Retinal degeneration Stress Therapeutic targets Wolfram Syndrome - metabolism Wolfram Syndrome - physiopathology Wolfram Syndrome - prevention & control
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