Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis

Chronic stress has been shown to facilitate progression of epithelial ovarian cancer (EOC), however, the neuro-endocranial mechanism participating in this process still remains unclear. Here, we reported that chronic restraint stress (CRS) promoted the abdominal implantation metastasis of EOC cells...

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Veröffentlicht in:	Cell death & disease 2020-08, Vol.11 (8), p.644, Article 644
Hauptverfasser:	Bu, Shixia, Wang, Qian, Sun, Junyan, Li, Xiao, Gu, Tingting, Lai, Dongmei
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 13/51 13/95 14/1 14/105 14/19 38/1 631/154/433 631/67/1517/1709 64/60 82 82/1 AKT protein Animals Antibodies beta Catenin - metabolism Biochemistry Biomedical and Life Sciences Carcinoma, Ovarian Epithelial - metabolism Carcinoma, Ovarian Epithelial - physiopathology Cell Biology Cell Culture Cell Line, Tumor Cell Movement - drug effects Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects Female Gene Expression Regulation, Neoplastic - drug effects Humans Immunology Life Sciences Melatonin Melatonin - metabolism Melatonin - pharmacology Mesenchyme Metastases Metastasis Mice Mice, Nude Neoplasm Metastasis - physiopathology Norepinephrine Norepinephrine - metabolism Ovarian cancer Ovarian Neoplasms - metabolism Proto-Oncogene Proteins c-akt - metabolism Snail Family Transcription Factors - metabolism Stress, Physiological - physiology Transcription β-Catenin
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