Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia

Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H 2 O 2 and lipid hydroperoxides (LOOHs)). Here we define the r...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), Article 13968
Hauptverfasser:	Pharaoh, Gavin, Brown, Jacob L., Sataranatarajan, Kavithalakshmi, Kneis, Parker, Bian, Jan, Ranjit, Rojina, Hadad, Niran, Georgescu, Constantin, Rabinovitch, Peter, Ran, Qitao, Wren, Jonathan D., Freeman, Willard, Kinter, Michael, Richardson, Arlan, Van Remmen, Holly
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1888/1493 631/443 631/443/319/333 631/443/7 631/45/287/1187 631/45/608 Age Aging Arachidonic acid Atrophy Denervation Electron transport chain Gene expression Health sciences Humanities and Social Sciences Hydrogen peroxide Innervation Intervention Lipid peroxidation Lipids Medical research Metabolism Metabolites Mitochondria multidisciplinary Musculoskeletal system Oxidative stress Phospholipase A2 Quality of life Sarcopenia Science Science (multidisciplinary) Surgery
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