On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2

The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of viral replication. Here, we performed a bioinformatic analysis of published and purported SARS-CoV-2 antivirals including imatin...

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Veröffentlicht in:	Cell death & disease 2020-08, Vol.11 (8), p.656-656, Article 656
Hauptverfasser:	Sauvat, Allan, Ciccosanti, Fabiola, Colavita, Francesca, Di Rienzo, Martina, Castilletti, Concetta, Capobianchi, Maria Rosaria, Kepp, Oliver, Zitvogel, Laurence, Fimia, Gian Maria, Piacentini, Mauro, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	38/77 631/154/1435/2418 692/699/255/2514 Animals Antibodies Antiviral agents Antiviral Agents - pharmacology Betacoronavirus - physiology Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Death - drug effects Chlorocebus aethiops Chloroquine Chlorpromazine Coronaviridae Coronavirus Infections - metabolism Coronavirus Infections - virology Coronaviruses COVID-19 Drug Evaluation, Preclinical - methods Emetine Endosomes Enzyme inhibitors Haloperidol Hydroxychloroquine Hydroxychloroquine - pharmacology Imatinib Imatinib Mesylate - pharmacology Immunology Life Sciences Lipophilic Lysosomes Lysosomes - drug effects Microbiology and Parasitology Organelles Pandemics Phagosomes Pharmaceutical sciences Pharmacology Pneumonia, Viral - metabolism Pneumonia, Viral - virology Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase Quantitative Methods Replication RNA, Viral - drug effects SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Vero Cells Viral Load - drug effects Virology Virus Replication - drug effects
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