Idiopathic Orbital Inflammation Appearing on the Affected Side of Preceding Myasthenia Gravis
The patient was a 70-year-old man with idiopathic orbital inflammation (IOI) that appeared on the severely affected side of preceding myasthenia gravis (MG). The patient was diagnosed with MG 5 years prior to the onset of IOI. When IOI was diagnosed, an edrophonium test was negative. IOI was conside...
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Veröffentlicht in: | Internal Medicine 2020/07/15, Vol.59(14), pp.1763-1767 |
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creator | Fujita, Satoru Furuta, Natsumi Maruyama, Tokuzo Tsukagoshi, Setsuki Nagashima, Kazuaki Fujita, Yukio Nagai, Kazuki Kashima, Tomoyuki Tanaka, Makoto Miki, Izumi Yamazaki, Ayako Ikota, Hayato Oyama, Tetsunari Ikeda, Yoshio |
description | The patient was a 70-year-old man with idiopathic orbital inflammation (IOI) that appeared on the severely affected side of preceding myasthenia gravis (MG). The patient was diagnosed with MG 5 years prior to the onset of IOI. When IOI was diagnosed, an edrophonium test was negative. IOI was considered because he complained of left orbital pain, eyelid swelling, and cerebral MRI exhibited the enhanced lesions along the left orbital periosteum. A biopsy specimen revealed pathological findings compatible with IOI. The administration of corticosteroids was effective for improving the ocular symptoms. IOI should be considered when ocular symptoms deteriorated with soft tissue swelling/pain in MG patients. |
doi_str_mv | 10.2169/internalmedicine.4235-19 |
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The patient was diagnosed with MG 5 years prior to the onset of IOI. When IOI was diagnosed, an edrophonium test was negative. IOI was considered because he complained of left orbital pain, eyelid swelling, and cerebral MRI exhibited the enhanced lesions along the left orbital periosteum. A biopsy specimen revealed pathological findings compatible with IOI. The administration of corticosteroids was effective for improving the ocular symptoms. IOI should be considered when ocular symptoms deteriorated with soft tissue swelling/pain in MG patients.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.4235-19</identifier><identifier>PMID: 32669516</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>Biopsy ; Case Report ; corticosteroid ; Corticosteroids ; Eyelid ; idiopathic orbital inflammation ; Internal medicine ; Magnetic resonance imaging ; Myasthenia ; Myasthenia gravis ; Neuromuscular junctions ; Pain ; Periosteum</subject><ispartof>Internal Medicine, 2020/07/15, Vol.59(14), pp.1763-1767</ispartof><rights>2020 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><rights>Copyright © 2020 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c589t-f49dfa5f1dc4e07d3e10cfe35504441d6ded3c35974aa1a0cc029eec4604c3083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434539/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434539/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Fujita, Satoru</creatorcontrib><creatorcontrib>Furuta, Natsumi</creatorcontrib><creatorcontrib>Maruyama, Tokuzo</creatorcontrib><creatorcontrib>Tsukagoshi, Setsuki</creatorcontrib><creatorcontrib>Nagashima, Kazuaki</creatorcontrib><creatorcontrib>Fujita, Yukio</creatorcontrib><creatorcontrib>Nagai, Kazuki</creatorcontrib><creatorcontrib>Kashima, Tomoyuki</creatorcontrib><creatorcontrib>Tanaka, Makoto</creatorcontrib><creatorcontrib>Miki, Izumi</creatorcontrib><creatorcontrib>Yamazaki, Ayako</creatorcontrib><creatorcontrib>Ikota, Hayato</creatorcontrib><creatorcontrib>Oyama, Tetsunari</creatorcontrib><creatorcontrib>Ikeda, Yoshio</creatorcontrib><title>Idiopathic Orbital Inflammation Appearing on the Affected Side of Preceding Myasthenia Gravis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>The patient was a 70-year-old man with idiopathic orbital inflammation (IOI) that appeared on the severely affected side of preceding myasthenia gravis (MG). The patient was diagnosed with MG 5 years prior to the onset of IOI. When IOI was diagnosed, an edrophonium test was negative. IOI was considered because he complained of left orbital pain, eyelid swelling, and cerebral MRI exhibited the enhanced lesions along the left orbital periosteum. A biopsy specimen revealed pathological findings compatible with IOI. The administration of corticosteroids was effective for improving the ocular symptoms. IOI should be considered when ocular symptoms deteriorated with soft tissue swelling/pain in MG patients.</description><subject>Biopsy</subject><subject>Case Report</subject><subject>corticosteroid</subject><subject>Corticosteroids</subject><subject>Eyelid</subject><subject>idiopathic orbital inflammation</subject><subject>Internal medicine</subject><subject>Magnetic resonance imaging</subject><subject>Myasthenia</subject><subject>Myasthenia gravis</subject><subject>Neuromuscular junctions</subject><subject>Pain</subject><subject>Periosteum</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNplkVFr2zAUhc3YWLNu_0Gwl724kyzJtl4GoaxdoCWDbY9D3EpXiYItZ5JS6L-fvITA2pcrLvrO0UGnqgijVw1r1WcfMsYAw4jWGx_wSjRc1ky9qhaMC1V3ZX1dLahifd2UcVG9S2lHKe871bytLnjTtkqydlH9Xlk_7SFvvSHr-OAzDGQV3ADjCNlPgSz3e4Tow4aUJW-RLJ1Dk9GSH94imRz5HtGUHIW4f4JUkOCB3EZ49Ol99cbBkPDD6bysft18_Xn9rb5b366ul3e1kb3KtRPKOpCOWSOQdpYjo8Yhl5IKIZhtLVpuuFSdAGBAjaGNQjSipcJw2vPL6svRd394KH9iMOQIg95HP0J80hN4_f9N8Fu9mR51J7iQXBWDTyeDOP05YMp69MngMEDA6ZB0I5qSRKhmfuvjM3Q3HeYy_lFKSsVFV6j-SJk4pRTRncMwqucO9fMO9dyhZnOW9VG6Sxk2eBZCzN4M-FIolWZinieHM2m2EDUG_hcNpbJ6</recordid><startdate>20200715</startdate><enddate>20200715</enddate><creator>Fujita, Satoru</creator><creator>Furuta, Natsumi</creator><creator>Maruyama, Tokuzo</creator><creator>Tsukagoshi, Setsuki</creator><creator>Nagashima, Kazuaki</creator><creator>Fujita, Yukio</creator><creator>Nagai, Kazuki</creator><creator>Kashima, Tomoyuki</creator><creator>Tanaka, Makoto</creator><creator>Miki, Izumi</creator><creator>Yamazaki, Ayako</creator><creator>Ikota, Hayato</creator><creator>Oyama, Tetsunari</creator><creator>Ikeda, Yoshio</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200715</creationdate><title>Idiopathic Orbital Inflammation Appearing on the Affected Side of Preceding Myasthenia Gravis</title><author>Fujita, Satoru ; Furuta, Natsumi ; Maruyama, Tokuzo ; Tsukagoshi, Setsuki ; Nagashima, Kazuaki ; Fujita, Yukio ; Nagai, Kazuki ; Kashima, Tomoyuki ; Tanaka, Makoto ; Miki, Izumi ; Yamazaki, Ayako ; Ikota, Hayato ; Oyama, Tetsunari ; Ikeda, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-f49dfa5f1dc4e07d3e10cfe35504441d6ded3c35974aa1a0cc029eec4604c3083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biopsy</topic><topic>Case Report</topic><topic>corticosteroid</topic><topic>Corticosteroids</topic><topic>Eyelid</topic><topic>idiopathic orbital inflammation</topic><topic>Internal medicine</topic><topic>Magnetic resonance imaging</topic><topic>Myasthenia</topic><topic>Myasthenia gravis</topic><topic>Neuromuscular junctions</topic><topic>Pain</topic><topic>Periosteum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujita, Satoru</creatorcontrib><creatorcontrib>Furuta, Natsumi</creatorcontrib><creatorcontrib>Maruyama, Tokuzo</creatorcontrib><creatorcontrib>Tsukagoshi, Setsuki</creatorcontrib><creatorcontrib>Nagashima, Kazuaki</creatorcontrib><creatorcontrib>Fujita, Yukio</creatorcontrib><creatorcontrib>Nagai, Kazuki</creatorcontrib><creatorcontrib>Kashima, Tomoyuki</creatorcontrib><creatorcontrib>Tanaka, Makoto</creatorcontrib><creatorcontrib>Miki, Izumi</creatorcontrib><creatorcontrib>Yamazaki, Ayako</creatorcontrib><creatorcontrib>Ikota, Hayato</creatorcontrib><creatorcontrib>Oyama, Tetsunari</creatorcontrib><creatorcontrib>Ikeda, Yoshio</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujita, Satoru</au><au>Furuta, Natsumi</au><au>Maruyama, Tokuzo</au><au>Tsukagoshi, Setsuki</au><au>Nagashima, Kazuaki</au><au>Fujita, Yukio</au><au>Nagai, Kazuki</au><au>Kashima, Tomoyuki</au><au>Tanaka, Makoto</au><au>Miki, Izumi</au><au>Yamazaki, Ayako</au><au>Ikota, Hayato</au><au>Oyama, Tetsunari</au><au>Ikeda, Yoshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Idiopathic Orbital Inflammation Appearing on the Affected Side of Preceding Myasthenia Gravis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2020-07-15</date><risdate>2020</risdate><volume>59</volume><issue>14</issue><spage>1763</spage><epage>1767</epage><pages>1763-1767</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>The patient was a 70-year-old man with idiopathic orbital inflammation (IOI) that appeared on the severely affected side of preceding myasthenia gravis (MG). The patient was diagnosed with MG 5 years prior to the onset of IOI. When IOI was diagnosed, an edrophonium test was negative. IOI was considered because he complained of left orbital pain, eyelid swelling, and cerebral MRI exhibited the enhanced lesions along the left orbital periosteum. A biopsy specimen revealed pathological findings compatible with IOI. The administration of corticosteroids was effective for improving the ocular symptoms. IOI should be considered when ocular symptoms deteriorated with soft tissue swelling/pain in MG patients.</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>32669516</pmid><doi>10.2169/internalmedicine.4235-19</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biopsy Case Report corticosteroid Corticosteroids Eyelid idiopathic orbital inflammation Internal medicine Magnetic resonance imaging Myasthenia Myasthenia gravis Neuromuscular junctions Pain Periosteum |
title | Idiopathic Orbital Inflammation Appearing on the Affected Side of Preceding Myasthenia Gravis |
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