Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy

Endogenous control mechanisms, including immune checkpoints and immunosuppressive cells, are exploited in the process of tumorigenesis to weaken the anti-tumor immune response. Cancer treatment by chemotherapy or immune checkpoint inhibition can lead to changes of checkpoint expression, which influe...

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Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (15), p.5181
Hauptverfasser:	Puntigam, Lisa K, Jeske, Sandra S, Götz, Marlies, Greiner, Jochen, Laban, Simon, Theodoraki, Marie-Nicole, Doescher, Johannes, Weissinger, Stephanie E, Brunner, Cornelia, Hoffmann, Thomas K, Schuler, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alphapapillomavirus - isolation & purification Apoptosis BTLA protein Cancer therapies CD137 antigen Cell activation Cell death Chemotherapy Cohort Studies Female Flow cytometry Head & neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - immunology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - virology Human papillomavirus Humans Immune checkpoint Immune Checkpoint Proteins - blood Immune Checkpoint Proteins - metabolism Immune system Immunohistochemistry Immunomodulation Immunoregulation Immunotherapy Immunotherapy - methods Leukocytes, Mononuclear - metabolism Lymphocytes Lymphocytes B Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Male Metastasis Middle Aged Monoclonal antibodies Mucin Nivolumab - therapeutic use OX40 Ligand - blood OX40 Ligand - metabolism PD-1 protein PD-L1 protein Peripheral blood Populations Programmed Cell Death 1 Receptor - blood Programmed Cell Death 1 Receptor - metabolism Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - immunology Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - virology T-Lymphocytes, Regulatory - immunology Targeted cancer therapy Tumor necrosis factor Tumor necrosis factor receptors Tumor necrosis factor-TNF Tumor-infiltrating lymphocytes Tumorigenesis Tumors
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