3-Hydroxyolean-12-en-27-oic Acids Inhibit RANKL-Induced Osteoclastogenesis in Vitro and Inflammation-Induced Bone Loss in Vivo

Olean-12-en-27-oic acids possess a variety of pharmacological effects. However, their effects and underlying mechanisms on osteoclastogenesis remain unclear. This study aimed to investigate the anti-osteoclastogenic effects of five olean-12-en-27-oic acid derivatives including 3α,23-isopropylidenedi...

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Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (15), p.5240
Hauptverfasser:	Seo, Wonyoung, Lee, Suhyun, Tran, Phuong Thao, Ngo, Thi Quynh-Mai, Kim, Okwha, Le, Thanh Huong, Dang, Nguyen Hai, Hwangbo, Cheol, Min, Byung Sun, Lee, Jeong-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Acids Actin Animals Biomedical materials Bone diseases Bone growth Bone loss Bone marrow Bone Resorption - chemically induced Bone Resorption - drug therapy Bone Resorption - metabolism Bone Resorption - pathology c-Fos protein Cathepsin K Dimensional analysis Extracellular signal-regulated kinase Kinases Lead compounds Lipopolysaccharides Lipopolysaccharides - toxicity Lymphocytes MAP Kinase Signaling System - drug effects Mice Mice, Inbred ICR Natural products NF-AT protein Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Osteoclastogenesis Osteoclasts Osteoclasts - metabolism Osteoclasts - pathology Osteolysis Phosphorylation RANK Ligand - metabolism RAW 264.7 Cells Src protein TRANCE protein Transcription factors
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