Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling
Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-κB. Parthenolide (PTL) is an abundant sesquiterpene...
Gespeichert in:
Veröffentlicht in: | International journal of molecular sciences 2020-07, Vol.21 (15), p.5433 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 15 |
container_start_page | 5433 |
container_title | International journal of molecular sciences |
container_volume | 21 |
creator | Park, Jin-Ho Kang, Young-Hoon Hwang, Sun-Chul Oh, Se Heang Byun, June-Ho |
description | Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-κB. Parthenolide (PTL) is an abundant sesquiterpene lactone, found in Mexican Indian Asteraceae family plants, with reported anti-inflammatory activity, through the inhibition of a common step in the NF-κB activation pathway. This study examined the effects of PTL on the enhanced, in vitro, osteogenic phenotypes of human periosteum-derived cells (hPDCs), mediated by the inflammatory cytokine tumor necrosis factor (TNF)-α. PTL had no significant effects on hPDC viability or osteoblastic activities, whereas TNF-α had positive effects on the in vitro osteoblastic differentiation of hPDCs. c-Jun N-terminal kinase (JNK) signaling played an important role in the enhanced osteoblastic differentiation of TNF-α-treated hPDCs. Treatment with 1 µM PTL did not affect TNF-α-treated hPDCs; however, 5 and 10 µM PTL treatment decreased the histochemical detection and activity of alkaline phosphatase (ALP), alizarin red-positive mineralization, and the expression of ALP and osteocalcin mRNA. JNK phosphorylation decreased significantly in TNF-α-treated hPDCs pretreated with PTL. These results suggested that PTL exerts negative effects on the increased osteoblastic differentiation of TNF-α-treated hPDCs by inhibiting JNK signaling. |
doi_str_mv | 10.3390/ijms21155433 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7432707</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2430267633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-650f96b118bffb173b24a5a1b9e70b04751679776e5eea7118882cbecc5b54953</originalsourceid><addsrcrecordid>eNpVkctuEzEUhi0EoqWwY40ssWXA13Fmg4SilBaqtBKFrWVPzkwcZuzUdiLNI_A4vAjPhKOWKqx8rPOd_1x-hF5T8p7zhnxwmzExSqUUnD9Bp1QwVhFSq6dH8Ql6kdKGEMaZbJ6jE86UpLWYnaJfNybmNfgwuBXgC5PwEnqT3R7wouugzQkHjy89_uFyDHjh18a3sMLXKUPowbsW3xzK87SFhO1U0G4w42hyiBOeTzn8dB7w7fK8-vMb750pwNpZl53v8ZflV_zN9d4M5fcSPevMkODVw3uGvp8vbucX1dX158v5p6uqFZTlqpaka2pL6cx2naWKWyaMNNQ2oIgl4rCYapSqQQIYVbjZjLUW2lZaKRrJz9DHe93tzo6wasHnaAa9jW40cdLBOP1_xru17sNeK1HORlQRePsgEMPdDlLWm7CLZYmkmeCE1armvFDv7qk2hpQidI8dKNEH4_SxcQV_czzVI_zPKf4X4zWWmA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2430267633</pqid></control><display><type>article</type><title>Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Park, Jin-Ho ; Kang, Young-Hoon ; Hwang, Sun-Chul ; Oh, Se Heang ; Byun, June-Ho</creator><creatorcontrib>Park, Jin-Ho ; Kang, Young-Hoon ; Hwang, Sun-Chul ; Oh, Se Heang ; Byun, June-Ho</creatorcontrib><description>Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-κB. Parthenolide (PTL) is an abundant sesquiterpene lactone, found in Mexican Indian Asteraceae family plants, with reported anti-inflammatory activity, through the inhibition of a common step in the NF-κB activation pathway. This study examined the effects of PTL on the enhanced, in vitro, osteogenic phenotypes of human periosteum-derived cells (hPDCs), mediated by the inflammatory cytokine tumor necrosis factor (TNF)-α. PTL had no significant effects on hPDC viability or osteoblastic activities, whereas TNF-α had positive effects on the in vitro osteoblastic differentiation of hPDCs. c-Jun N-terminal kinase (JNK) signaling played an important role in the enhanced osteoblastic differentiation of TNF-α-treated hPDCs. Treatment with 1 µM PTL did not affect TNF-α-treated hPDCs; however, 5 and 10 µM PTL treatment decreased the histochemical detection and activity of alkaline phosphatase (ALP), alizarin red-positive mineralization, and the expression of ALP and osteocalcin mRNA. JNK phosphorylation decreased significantly in TNF-α-treated hPDCs pretreated with PTL. These results suggested that PTL exerts negative effects on the increased osteoblastic differentiation of TNF-α-treated hPDCs by inhibiting JNK signaling.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21155433</identifier><identifier>PMID: 32751648</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Activation ; Alizarin ; Alkaline phosphatase ; Anti-inflammatory agents ; Asteraceae - chemistry ; Biological activity ; Biomedical materials ; c-Jun protein ; Cell Differentiation - drug effects ; Cytokines ; Differentiation ; Gene expression ; Gene Expression Regulation, Developmental - drug effects ; Growth factors ; Humans ; Hydrolases - genetics ; Inflammation ; Inflammation - drug therapy ; Inflammation - genetics ; Inflammation - pathology ; Inflammatory diseases ; JNK Mitogen-Activated Protein Kinases ; JNK protein ; Kinases ; Lactones ; Lactones - chemistry ; Lactones - pharmacology ; MAP Kinase Signaling System ; Mineralization ; NF-kappa B ; NF-κB protein ; Osteoblastogenesis ; Osteoblasts ; Osteoblasts - drug effects ; Osteocalcin ; Osteogenesis - drug effects ; Osteogenesis - genetics ; Periosteum ; Periosteum - drug effects ; Periosteum - growth & development ; Phenotype ; Phenotypes ; Phosphorylation ; Phosphorylation - drug effects ; Phosphorylation - genetics ; Plants ; Sesquiterpene lactones ; Sesquiterpenes - chemistry ; Sesquiterpenes - pharmacology ; Stem cells ; Transcription factors ; Tumor Necrosis Factor-alpha - genetics ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>International journal of molecular sciences, 2020-07, Vol.21 (15), p.5433</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-650f96b118bffb173b24a5a1b9e70b04751679776e5eea7118882cbecc5b54953</citedby><cites>FETCH-LOGICAL-c412t-650f96b118bffb173b24a5a1b9e70b04751679776e5eea7118882cbecc5b54953</cites><orcidid>0000-0002-7623-2196</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432707/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432707/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32751648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jin-Ho</creatorcontrib><creatorcontrib>Kang, Young-Hoon</creatorcontrib><creatorcontrib>Hwang, Sun-Chul</creatorcontrib><creatorcontrib>Oh, Se Heang</creatorcontrib><creatorcontrib>Byun, June-Ho</creatorcontrib><title>Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-κB. Parthenolide (PTL) is an abundant sesquiterpene lactone, found in Mexican Indian Asteraceae family plants, with reported anti-inflammatory activity, through the inhibition of a common step in the NF-κB activation pathway. This study examined the effects of PTL on the enhanced, in vitro, osteogenic phenotypes of human periosteum-derived cells (hPDCs), mediated by the inflammatory cytokine tumor necrosis factor (TNF)-α. PTL had no significant effects on hPDC viability or osteoblastic activities, whereas TNF-α had positive effects on the in vitro osteoblastic differentiation of hPDCs. c-Jun N-terminal kinase (JNK) signaling played an important role in the enhanced osteoblastic differentiation of TNF-α-treated hPDCs. Treatment with 1 µM PTL did not affect TNF-α-treated hPDCs; however, 5 and 10 µM PTL treatment decreased the histochemical detection and activity of alkaline phosphatase (ALP), alizarin red-positive mineralization, and the expression of ALP and osteocalcin mRNA. JNK phosphorylation decreased significantly in TNF-α-treated hPDCs pretreated with PTL. These results suggested that PTL exerts negative effects on the increased osteoblastic differentiation of TNF-α-treated hPDCs by inhibiting JNK signaling.</description><subject>Activation</subject><subject>Alizarin</subject><subject>Alkaline phosphatase</subject><subject>Anti-inflammatory agents</subject><subject>Asteraceae - chemistry</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>c-Jun protein</subject><subject>Cell Differentiation - drug effects</subject><subject>Cytokines</subject><subject>Differentiation</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Hydrolases - genetics</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - genetics</subject><subject>Inflammation - pathology</subject><subject>Inflammatory diseases</subject><subject>JNK Mitogen-Activated Protein Kinases</subject><subject>JNK protein</subject><subject>Kinases</subject><subject>Lactones</subject><subject>Lactones - chemistry</subject><subject>Lactones - pharmacology</subject><subject>MAP Kinase Signaling System</subject><subject>Mineralization</subject><subject>NF-kappa B</subject><subject>NF-κB protein</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts</subject><subject>Osteoblasts - drug effects</subject><subject>Osteocalcin</subject><subject>Osteogenesis - drug effects</subject><subject>Osteogenesis - genetics</subject><subject>Periosteum</subject><subject>Periosteum - drug effects</subject><subject>Periosteum - growth & development</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Phosphorylation</subject><subject>Phosphorylation - drug effects</subject><subject>Phosphorylation - genetics</subject><subject>Plants</subject><subject>Sesquiterpene lactones</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Stem cells</subject><subject>Transcription factors</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpVkctuEzEUhi0EoqWwY40ssWXA13Fmg4SilBaqtBKFrWVPzkwcZuzUdiLNI_A4vAjPhKOWKqx8rPOd_1x-hF5T8p7zhnxwmzExSqUUnD9Bp1QwVhFSq6dH8Ql6kdKGEMaZbJ6jE86UpLWYnaJfNybmNfgwuBXgC5PwEnqT3R7wouugzQkHjy89_uFyDHjh18a3sMLXKUPowbsW3xzK87SFhO1U0G4w42hyiBOeTzn8dB7w7fK8-vMb750pwNpZl53v8ZflV_zN9d4M5fcSPevMkODVw3uGvp8vbucX1dX158v5p6uqFZTlqpaka2pL6cx2naWKWyaMNNQ2oIgl4rCYapSqQQIYVbjZjLUW2lZaKRrJz9DHe93tzo6wasHnaAa9jW40cdLBOP1_xru17sNeK1HORlQRePsgEMPdDlLWm7CLZYmkmeCE1armvFDv7qk2hpQidI8dKNEH4_SxcQV_czzVI_zPKf4X4zWWmA</recordid><startdate>20200730</startdate><enddate>20200730</enddate><creator>Park, Jin-Ho</creator><creator>Kang, Young-Hoon</creator><creator>Hwang, Sun-Chul</creator><creator>Oh, Se Heang</creator><creator>Byun, June-Ho</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7623-2196</orcidid></search><sort><creationdate>20200730</creationdate><title>Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling</title><author>Park, Jin-Ho ; Kang, Young-Hoon ; Hwang, Sun-Chul ; Oh, Se Heang ; Byun, June-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-650f96b118bffb173b24a5a1b9e70b04751679776e5eea7118882cbecc5b54953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Activation</topic><topic>Alizarin</topic><topic>Alkaline phosphatase</topic><topic>Anti-inflammatory agents</topic><topic>Asteraceae - chemistry</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>c-Jun protein</topic><topic>Cell Differentiation - drug effects</topic><topic>Cytokines</topic><topic>Differentiation</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Hydrolases - genetics</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - genetics</topic><topic>Inflammation - pathology</topic><topic>Inflammatory diseases</topic><topic>JNK Mitogen-Activated Protein Kinases</topic><topic>JNK protein</topic><topic>Kinases</topic><topic>Lactones</topic><topic>Lactones - chemistry</topic><topic>Lactones - pharmacology</topic><topic>MAP Kinase Signaling System</topic><topic>Mineralization</topic><topic>NF-kappa B</topic><topic>NF-κB protein</topic><topic>Osteoblastogenesis</topic><topic>Osteoblasts</topic><topic>Osteoblasts - drug effects</topic><topic>Osteocalcin</topic><topic>Osteogenesis - drug effects</topic><topic>Osteogenesis - genetics</topic><topic>Periosteum</topic><topic>Periosteum - drug effects</topic><topic>Periosteum - growth & development</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Phosphorylation</topic><topic>Phosphorylation - drug effects</topic><topic>Phosphorylation - genetics</topic><topic>Plants</topic><topic>Sesquiterpene lactones</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Stem cells</topic><topic>Transcription factors</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jin-Ho</creatorcontrib><creatorcontrib>Kang, Young-Hoon</creatorcontrib><creatorcontrib>Hwang, Sun-Chul</creatorcontrib><creatorcontrib>Oh, Se Heang</creatorcontrib><creatorcontrib>Byun, June-Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jin-Ho</au><au>Kang, Young-Hoon</au><au>Hwang, Sun-Chul</au><au>Oh, Se Heang</au><au>Byun, June-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-07-30</date><risdate>2020</risdate><volume>21</volume><issue>15</issue><spage>5433</spage><pages>5433-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Nuclear factor kappa B (NF-κB) regulates inflammatory gene expression and represents a likely target for novel disease treatment approaches, including skeletal disorders. Several plant-derived sesquiterpene lactones can inhibit the activation of NF-κB. Parthenolide (PTL) is an abundant sesquiterpene lactone, found in Mexican Indian Asteraceae family plants, with reported anti-inflammatory activity, through the inhibition of a common step in the NF-κB activation pathway. This study examined the effects of PTL on the enhanced, in vitro, osteogenic phenotypes of human periosteum-derived cells (hPDCs), mediated by the inflammatory cytokine tumor necrosis factor (TNF)-α. PTL had no significant effects on hPDC viability or osteoblastic activities, whereas TNF-α had positive effects on the in vitro osteoblastic differentiation of hPDCs. c-Jun N-terminal kinase (JNK) signaling played an important role in the enhanced osteoblastic differentiation of TNF-α-treated hPDCs. Treatment with 1 µM PTL did not affect TNF-α-treated hPDCs; however, 5 and 10 µM PTL treatment decreased the histochemical detection and activity of alkaline phosphatase (ALP), alizarin red-positive mineralization, and the expression of ALP and osteocalcin mRNA. JNK phosphorylation decreased significantly in TNF-α-treated hPDCs pretreated with PTL. These results suggested that PTL exerts negative effects on the increased osteoblastic differentiation of TNF-α-treated hPDCs by inhibiting JNK signaling.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32751648</pmid><doi>10.3390/ijms21155433</doi><orcidid>https://orcid.org/0000-0002-7623-2196</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1422-0067 |
ispartof | International journal of molecular sciences, 2020-07, Vol.21 (15), p.5433 |
issn | 1422-0067 1661-6596 1422-0067 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7432707 |
source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Activation Alizarin Alkaline phosphatase Anti-inflammatory agents Asteraceae - chemistry Biological activity Biomedical materials c-Jun protein Cell Differentiation - drug effects Cytokines Differentiation Gene expression Gene Expression Regulation, Developmental - drug effects Growth factors Humans Hydrolases - genetics Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Inflammatory diseases JNK Mitogen-Activated Protein Kinases JNK protein Kinases Lactones Lactones - chemistry Lactones - pharmacology MAP Kinase Signaling System Mineralization NF-kappa B NF-κB protein Osteoblastogenesis Osteoblasts Osteoblasts - drug effects Osteocalcin Osteogenesis - drug effects Osteogenesis - genetics Periosteum Periosteum - drug effects Periosteum - growth & development Phenotype Phenotypes Phosphorylation Phosphorylation - drug effects Phosphorylation - genetics Plants Sesquiterpene lactones Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Stem cells Transcription factors Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-TNF Tumor necrosis factor-α |
title | Parthenolide Has Negative Effects on In Vitro Enhanced Osteogenic Phenotypes by Inflammatory Cytokine TNF-α via Inhibiting JNK Signaling |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T18%3A33%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parthenolide%20Has%20Negative%20Effects%20on%20In%20Vitro%20Enhanced%20Osteogenic%20Phenotypes%20by%20Inflammatory%20Cytokine%20TNF-%CE%B1%20via%20Inhibiting%20JNK%20Signaling&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Park,%20Jin-Ho&rft.date=2020-07-30&rft.volume=21&rft.issue=15&rft.spage=5433&rft.pages=5433-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms21155433&rft_dat=%3Cproquest_pubme%3E2430267633%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2430267633&rft_id=info:pmid/32751648&rfr_iscdi=true |